DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eps-15 and Eps15l1

DIOPT Version :9

Sequence 1:	NP_611965.2	Gene:	Eps-15 / 37961	FlyBaseID:	FBgn0035060	Length:	1253	Species:	Drosophila melanogaster
Sequence 2:	XP_006509607.1	Gene:	Eps15l1 / 13859	MGIID:	104582	Length:	923	Species:	Mus musculus

Alignment Length:	944	Identity:	340/944 - (36%)
Similarity:	472/944 - (50%)	Gaps:	178/944 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VYEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSL 79
            :||:|||.:||..||.:.|..||.|||||||||::|.:||||:||.|||||||.||:|||:||:.
Mouse    18 LYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALRLVAC 82

  Fly    80 SQAGQVASMANIYLDIANPPKLGELPKTMPSRIQTVPVASGGVANGDWSIGVIDRLKYEQLFESL 144
            :|:|...:::::.|.:. |||..:....:        :|:...|...|::.|.::.|::.:||||
Mouse    83 AQSGHEVTLSSLSLTMP-PPKFHDTSSPL--------MATQSSAETHWAVRVEEKAKFDGIFESL 138

  Fly   145 HPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRTIPSV 209
            .|.||:|.|:|||.|||:||||:.:||.:|||:|.||||:||..||.|||||||:.|:|..:||:
Mouse   139 LPVNGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSI 203

  Fly   210 LPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAAIPPLPVAVPP 274
            |||             |.:||...                       |......|:|.||.:.||
Mouse   204 LPP-------------PLIPPSKR-----------------------KKTVFAGAVPVLPASPPP 232

  Fly   275 ---MTRIPPVGAVSSQPLIQTDPLIP---IGAPVMANADWVVTPADLKRFEEIFRQSDLDKDGLV 333
               :...|..|:|||  |..|..|.|   :..|.:|   |||..||..||:|||.::|||.||.|
Mouse   233 KDSLRSTPSHGSVSS--LNSTGSLSPKHSVKQPPVA---WVVPVADKMRFDEIFLKTDLDLDGYV 292

  Fly   334 SGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERK-QRGVDPPHVLNANMV 397
            ||.|||:||:.||:.|..||.||||.||.|:|||:.|||||||:|:::| .:|:|||.||:.:||
Mouse   293 SGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFALAMYFIQQKVSKGIDPPQVLSPDMV 357

  Fly   398 PPSMRATVAGVDLQPQEVKPTYSN-----PELEMISKEIEELARERRVLETEIAQKEADVRIKNG 457
            |||.|.|..     |.......|.     .||:.||:||.:|.||:..||.:|.:||..:|.|..
Mouse   358 PPSERGTPI-----PDSSSTLASGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTS 417

  Fly   458 EVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNEQVTKIRDQC 522
            ||:.||::||..|::|::||.|:.:||.|||::..|.:....:|::|........:.::.::.|.
Mouse   418 EVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQI 482

  Fly   523 HMQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVTQ 587
            ..||..:..||.:||..:|||.:|:.||..|::...:...:|..:...|:.||..|:..||.::|
Mouse   483 QSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQ 547

  Fly   588 LLETQRQMTDALLICRAAMENQNAELVSEYQLKIEPDFDEARKTLTKEVQLPK-------DDPFE 645
            |.|:..:...:|     ...:|..:.||...|   ||.    .||.:.:.|.:       ||||:
Mouse   548 LQESHLEAHRSL-----EQYDQVPDGVSGTSL---PDL----ATLNEGILLAERGGFGAMDDPFK 600

  Fly   646 ------ENNSGAAN----QATNGF------GSDPFSGQPVNKPAIS---TGFDDSFNMSSGFDSG 691
                  .|||...:    ||.:.|      |:|||.|.|......|   |...|.|......:|
Mouse   601 NKALLFSNNSQELHPDPFQAEDPFKSDPFKGADPFKGDPFQSDPFSEQQTAATDPFGGDPFKES- 664

  Fly   692 FDAFGQSGAGSAF-GQTQRDPFGSDAFAANKS--NAITPEPGKDDF--------GSDPFAALHAP 745
             |.|..|.:...| .||:.|||.||.|..|.|  :.:.|....|.|        |||||..|. |
Mouse   665 -DPFHSSSSDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSISSKGSDPFGTLD-P 727

  Fly   746 TGQGQVLSPN-----AQKSGPPP------------------RPESPSPALPPKKSKVPPPRPAPP 787
            .|.....|..     :|.|.|||                  :.:..:|||||||.  .||||.||
Mouse   728 FGSSSFSSAEGFADFSQMSKPPPSGPFSSSLGGTGFSDDPFKSKQDTPALPPKKP--APPRPKPP 790

  Fly   788 RAAQPTGGFGS------GGGG------GFADF---------------DDFDNKLHHIPSAPSPSA 825
            ..| ..|..|:      ||..      |.:||               |.|.||     .......
Mouse   791 SEA-AAGEKGTVVYTLLGGQSTPVSQLGSSDFPESPDPFQPLGADSGDPFQNK-----KGFGDPF 849

  Fly   826 TALSPLPPTLPAPIPVVSGSSLLDSFTLFDDPGQ 859
            :...|..|:..|..|..|.|...| ||.|.:..|
Mouse   850 SGKDPFAPSSSAKPPKTSSSGFAD-FTSFGNEEQ 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	42/65 (65%)
		EH	126..215	CDD:197477	50/88 (57%)
		EH	137..202	CDD:238009	40/64 (63%)
		EH	307..402	CDD:197477	58/95 (61%)
		EH	318..384	CDD:238009	41/66 (62%)
		RILP-like	<445..548	CDD:304877	35/102 (34%)
		Spc24	529..>584	CDD:285486	17/54 (31%)
Eps15l1	XP_006509607.1	EF-hand_4	13..103	CDD:332633	47/85 (55%)
		EH	121..200	CDD:197477	45/78 (58%)
		EH	266..362	CDD:197477	59/98 (60%)
		Smc	<383..>564	CDD:224117	60/185 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	154	1.000	Domainoid score	I4250
eggNOG	1	0.900	-	-		E1_KOG0998
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31881
Inparanoid	1	1.050	458	1.000	Inparanoid score	I1564
Isobase	1	0.950	-	0.721928	Normalized mean entropy	S4078
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D360276at33208
OrthoFinder	1	1.000	-	-		FOG0001628
OrthoInspector	1	1.000	-	-		otm42994
orthoMCL	1	0.900	-	-		OOG6_101578
Panther	1	1.100	-	-	O	PTHR11216
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R396
SonicParanoid	1	1.000	-	-		X924
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.810