Protein Alignment Eps-15 and Eps15

DIOPT Version :10

• Sequence 1: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Sequence 2: XP_006502801.2
• Gene: Eps15 / 13858
• MGIID: 104583
• Length: 933
• Species: Mus musculus
• Alignment Length: 902
• Identity: 279/902 - (30%)
• Similarity: 414/902 - (45%)
• Gaps: 216/902 - (23%)

  Fly    15 VYEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSL 79
            |||.||:.::...||.:.|:.||.|||||||.|::|.:||||:|..|||.|.|..|||||:||:.
Mouse    18 VYEKYYRQVEAGNTGRVLALDAAAFLKKSGLPDLILGKIWDLADTDGKGVLSKQEFFVALRLVAC 82

  Fly    80 SQAGQVASMANIYLDIANPPKLGELPKTMPSRIQTVPVASGG--VANGDWSIGVIDRLKYEQLFE 142
            :|.|...|::::.|.:. ||:..:         .:.|:.:.|  ||...|::...|:.||:.:|:
Mouse    83 AQNGLEVSLSSLSLAVP-PPRFHD---------SSSPLLTSGPSVAELPWAVKSEDKAKYDAIFD 137

  Fly   143 SLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRTIP 207
            ||.|.:|.|.|:|||.||::||||:.|||.:|:|:|.|.||.||..||.|||.|||..|:|..:|
Mouse   138 SLSPVDGFLSGDKVKPVLLNSKLPVEILGRVWELSDIDHDGKLDRDEFAVAMFLVYCALEKEPVP 202

  Fly   208 SVLPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAAIPPLPVAV 272
            ..||              ||:.||.....:..:.|              |.:.|.:|      |.
Mouse   203 MSLP--------------PALVPPSKRKTVSISGS--------------KWVIPSSA------AK 233

  Fly   273 PPMTRIPPVGAVSSQPLIQTDPLIPIGAPVMANADWVVTPADLKRFEEIFRQSDLDKDGLVSGLE 337
            .....:||||            :.|..||:   ..|||:||:..:::|||.::|.|.||.|||||
Mouse   234 ESYHSLPPVG------------ISPTKAPL---RQWVVSPAEKAKYDEIFLKTDKDMDGYVSGLE 283

  Fly   338 VKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQ-RGVDPPHVLNANMVPPSM 401
            |::.|:|:|:|...||.||:||||...|||:.:|||||...:.:|. :|:||||.|...|:|||.
Mouse   284 VRETFLKTGLPSALLAHIWSLCDTKGCGKLSKDQFALAFHLINQKLIKGIDPPHSLTPEMIPPSD 348

  Fly   402 RATVAGVDLQPQEVKPTYSNP--------ELEMISKEIEELARERRVLETEIAQKEADVRIKNGE 458
            |:::        :...|.|:|        ||:.::.||.:|.||:..:|.::.:||..|:.:..|
Mouse   349 RSSL--------QKNITGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTVKQRTSE 405

  Fly   459 VRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNEQVTKIRDQCH 523
            |:.||.|:...:..|::|:.|:.:.|:.|.:|..|.:.....|..|....:...:.::.::.:..
Mouse   406 VQDLQDEVQRESINLQKLQAQKQQVQELLGELDEQKAQLEEQLQEVRKKCAEEAQLISSLKAEIT 470

  Fly   524 MQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVTQL 588
            .||..|:..|.||...|.||.:|:.|.|.|::..:|...:|..|..|||.:|.:|||::..:...
Mouse   471 SQESQISSYEEELLKAREELSRLQQETAQLEESVESGKAQLEPLQQHLQESQQEISSMQMRLEMK 535

  Fly   589 -LETQRQM---------------TDALLICRAAME----NQNAELVSEYQLKIEPDFDEARKTLT 633
             |||....               ||...:..::.|    |::||  .:..|:.||...|:....:
Mouse   536 DLETDNNQSNWSSSPQSVLVNGATDYCSLSTSSSETANFNEHAE--GQNNLESEPTHQESSVRSS 598

  Fly   634 KEVQLPKD-----------------------------DPFEENNSGAAN----------QATNGF 659
            .|: .|.|                             |||...:|...:          |:....
Mouse   599 PEI-APSDVTDESEAVTVAGNEKVTPRFDDDKHSKEEDPFNVESSSLTDAVADTNLDFFQSDPFV 662

  Fly   660 GSDPFSGQPVNKPAISTGFDDSFNMSSGFDSGFDAFGQSGAGSAFGQTQRDPF---GSDAFAANK 721
            |||||...|..|  |.....|.|..|..|.|  |.|        |.||..|||   .:|.|:|:.
Mouse   663 GSDPFKDDPFGK--IDPFGGDPFKGSDPFAS--DCF--------FKQTSTDPFTTSSTDPFSASS 715

  Fly   722 SNAITP----------EPG------KDDFGSDPFAALHAPTGQGQ-------------------- 750
            :::.|.          .||      ..|..:||||::......|.
Mouse   716 NSSNTSVETWKHNDPFAPGGTVVAAASDSATDPFASVFGNESFGDGFADFSTLSKVNNEDAFNPT 780

  Fly   751 -------------VLSPNAQKSGPPPRPESPSPALPPKKSKVPPPRPAPPRAAQPTG 794
                         :|...|.||      |...||||||..  .|.||.||    |.|
Mouse   781 ISSSTSSVTIAKPMLEETASKS------EDVPPALPPKVG--TPTRPCPP----PPG 825

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	35/65 (54%)
		EH	126..215	CDD:197477	44/88 (50%)
		EH	307..402	CDD:197477	49/95 (52%)
		SMC_prok_B	<423..>632	CDD:274008	61/228 (27%)
Eps15	XP_006502801.2	EH	13..103	CDD:197477	42/85 (49%)
		EH	121..215	CDD:197477	48/107 (45%)
		EH	253..349	CDD:197477	49/95 (52%)
		COG4372	366..>628	CDD:443500	64/264 (24%)