Protein Alignment Eps-15 and Eps-15

DIOPT Version :10

• Sequence 1: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Sequence 2: XP_061513545.1
• Gene: Eps-15 / 1280150
• VectorBaseID: AGAMI1_004409
• Length: 1245
• Species: Anopheles gambiae
• Alignment Length: 1368
• Identity: 611/1368 - (44%)
• Similarity: 778/1368 - (56%)
• Gaps: 245/1368 - (17%)

  Fly     4 DFARVCGKHIGVYEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKP 68
            |..::.|.||.:||||||.:|||....|.|:.||||||||||||||||||||||||:|||||.|.
Mosquito     3 DIVKIAGDHILIYEAYYKQLDPKEANEIGALDAAKFLKKSGLSDVVLSRIWDLSDPNGKGFLTKE 67

  Fly    69 GFFVALKLVSLSQAGQVASMANIYLDIANPPKLGELPKTMPSRIQTVPVASGGVANGDWSIGVID 133
            ||||:|||:.|:|.|...::.|||..::.|||:|:||| :|::::.:||.|     .|||:....
Mosquito    68 GFFVSLKLIGLAQEGSEINLKNIYNVLSKPPKVGDLPK-VPAQVKLLPVES-----TDWSMKPEK 126

  Fly   134 RLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVY 198
            |.:|||||:||.|.||:|||.||:..||:||||:..||.||||||||:||:||.|||.|||||||
Mosquito   127 RQQYEQLFDSLGPMNGLLPGAKVRMTLMNSKLPVETLGRIWDLADQDRDGSLDKHEFCVAMHLVY 191

  Fly   199 QTLQKRTIPSVLPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPA 263
            :.|.||.||::|||:|::        ..|..||..|........|...|.||||||||.|||||.
Mosquito   192 EALDKRAIPAMLPPQLQR--------NYAPQPPQNGGGFDAFGGGAADGAGGFVANFPSDIAPPP 248

  Fly   264 AIPPLPVAV---PPMTR--IPPV----GAVSSQPLIQTDPLIPIGAPVMANADWVVTPADLKRFE 319
            .:||||.|:   ||||.  ||||    |.|         ||:...||.:....|||:|.:..::|
Mosquito   249 VVPPLPAALARPPPMTAPVIPPVPMGLGGV---------PLVSAPAPPIEVTSWVVSPLERCKYE 304

  Fly   320 EIFRQSDLDKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQR 384
            |||.:||.|:||||||||:||:|::||:.|..||.|||||||||||||.:|:|.||||||:|.::
Mosquito   305 EIFNKSDTDRDGLVSGLEIKDVFLQSGVAQNKLAHIWALCDTNQSGKLKLEEFCLAMWFVDRAKK 369

  Fly   385 GVDPPHVLNANMVPPSMRATVAGVDLQPQE-VKPTYSNPELEMISKEIEELARERRVLETEIAQK 448
            |:|||..|..||||||:|.:..   :|.|| .:|||||||||||||||:|||:|||:||.|:|||
Mosquito   370 GIDPPQALAPNMVPPSLRKSSL---IQAQEPPQPTYSNPELEMISKEIDELAKERRLLEQEVAQK 431

  Fly   449 EADVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNE 513
            |||||||.||:||||||||||||||||||||:||||||||||:.|.......|..|:..|....:
Mosquito   432 EADVRIKGGELRSLQSELDTLTATLKQLENQKGEAQKRLDDLKNQQVDVDQALLEVACSIDEARQ 496

  Fly   514 QVTKIRDQCHMQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQI 578
            ||||||:||..||.|:.||||||:::|||||||:|||.||:|||:::.:|:.:||:.||.|||:|
Mosquito   497 QVTKIREQCQKQEATLKEQEGELDSRRSELQKLRDEEQSLEKEYNTSTKEVDRLTSQLQDTQLEI 561

  Fly   579 SSVRSMVTQLLETQRQMTDALLICRAAMENQNAELVSEYQLKIEPDFDEARKTL-TKEVQ-LPKD 641
            |.|::||||:.|.||||||||.:.|:|:|:.:..|||:|.|||||:|.||::.| .|||: ..|.
Mosquito   562 SQVKAMVTQIQEYQRQMTDALSMFRSAIESNDPILVSDYSLKIEPEFREAKQALEEKEVENANKR 626

  Fly   642 DPFEENNSGAANQATNGFGSDPFSGQPVNKPAISTGFDDSFNMSSGF------------------ 688
            |||.:|.|       ||||    :|:|.     .|||.|.|..|:||
Mosquito   627 DPFGDNRS-------NGFG----AGEPA-----ETGFGDDFKSSNGFATQFDVGSNGGFHGGTAA 675

  Fly   689 -----DSGFDAFGQSGAGSAFGQTQRDPFGS----DAFAANK-SNAITPEPGKDDFGSDPFAALH 743
                 :.||.|||......|.|....|||||    |.|...| |.::..||.||:||.||||.||
Mosquito   676 TGGFGEDGFGAFGAKAPSHAIGGGAADPFGSGAAADPFGDRKGSGSVAAEPAKDEFGCDPFAILH 740

  Fly   744 APTGQGQVLSPNAQKSGPPPRPESPSPALPPKKSKVPPPRPAPPRAAQ---PT-------GGFG- 797
            |||..||.|||:..||..|||||||||||||||:|.|||||||||..|   ||       ..||
Mosquito   741 APTTAGQALSPSPSKSVAPPRPESPSPALPPKKAKQPPPRPAPPRPMQGPTPTKPAPPASDAFGD 805

  Fly   798 SGGGGGFADFDDFDNKLHHIPSAPSPSATALSPLPPTLPAPIPVVSGSSLLDSFTLFDDPGQIHK 862
            |.|||.||:|.|||||                .|.|.....:...|.||...|.|.|   |....
Mosquito   806 SSGGGSFANFADFDNK----------------NLKPVTSQTLQQASPSSFASSGTAF---GSNRS 851

  Fly   863 QAASTPNPTPITVPTVHTLLQTSLSTPAAPSPALASLSTSGSGSVAGAGADLPSSVTIT----TA 923
            ...|:.|     ..|:.::|           ||:            ||.|.:..:.|||    |.
Mosquito   852 LTGSSSN-----AATLGSML-----------PAM------------GAAAPVTPTATITIEAATP 888

  Fly   924 PSLNNQHLSRSNTPLQNQRTADVKLETKAVVSVFDAFGEIGTRKAPTPSLITGPTDFKDDPFKDY 988
            |           ||      |...:....||:....|.  .:..||||..:   .||.|||||||
Mosquito   889 P-----------TP------AAASVVRSVVVTPVAQFA--SSSAAPTPVPV---ADFADDPFKDY 931

  Fly   989 RYEDPFSIKDPFA--EEGEEELSEGKGADHKRN------FAEDFS-------------------- 1025
            ||||||:|:||||  |:.::::::...:..|.|      |..:|.
Mosquito   932 RYEDPFNIEDPFADTEDDDKQVNDPFASTTKNNNNVLSAFDANFGHSTNTASVEELDELFKGVRI 996

  Fly  1026 SGD----------EIGSAAKTLSNIVNNNSIKPKAATPLNNDLLQQFDAFNLNSSPAPSHHSGTS 1080
            |||          ::.:....|:|  |||::.|...|..:......|||||.|.|...:...|.:
Mosquito   997 SGDGANTPVLNNNKLNNTTSRLNN--NNNTLSPIGTTTKSLFTSDPFDAFNDNFSKNTNQTDGAA 1059

  Fly  1081 YHSNSKPSHDSQTALDAFADFDD--FAATLATTGGSGAATT------ATTTGNTKLNNSFFDAFN 1137
            ....:..:.|...|| |....||  |.|..||||.|..:.|      |::||.|.|  ....:|.
Mosquito  1060 SLFGAFGNGDGGDAL-AKPTGDDSLFDAFRATTGSSTTSPTTVPPTGASSTGTTAL--MMLKSFE 1121

  Fly  1138 DNFSVIQSSSVPTGVVRPNDQRAKAFDA-FNDNFEDQFKTSPNANFAKFDGFEAHNFSSDFG--- 1198
            |.||.:.:::|....:..:......||| |:|.| ..|.|..::..         |.||..|
Mosquito  1122 DEFSKMDAANVLNNNLTTSSGSNNEFDAKFDDAF-SAFGTGASSTI---------NSSSSNGARY 1176

  Fly  1199 NASFGTT------------GKEKQNGQVDKKFQSKEPVK--DKFAADYSKPESFDADLEEALKRS 1249
            .|:||.|            |.....|.:.:...|.:|.|  ::|.|||||.|:||||||..|:||
Mosquito  1177 GAAFGATLPPPAAKSFKPNGGPSTTGSLKRPDGSADPPKVLERFNADYSKGETFDADLEAVLQRS 1241

  Fly  1250 VLD 1252
            :::
Mosquito  1242 LVE 1244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	49/65 (75%)
		EH	126..215	CDD:197477	57/88 (65%)
		EH	307..402	CDD:197477	60/94 (64%)
		SMC_prok_B	<423..>632	CDD:274008	135/208 (65%)
Eps-15	XP_061513545.1	None