DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eps-15 and SYNRG

DIOPT Version :9

Sequence 1:	NP_611965.2	Gene:	Eps-15 / 37961	FlyBaseID:	FBgn0035060	Length:	1253	Species:	Drosophila melanogaster
Sequence 2:	XP_016879565.1	Gene:	SYNRG / 11276	HGNCID:	557	Length:	1438	Species:	Homo sapiens

Alignment Length:	1403	Identity:	266/1403 - (18%)
Similarity:	415/1403 - (29%)	Gaps:	530/1403 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 LSQAGQVASMANI---YLDIANPPKLGELP--KTMPSRIQTVPVASGGVANGDWSIGVIDRLKYE 138
            :|| |.:|..|.|   .:..|..|.||:.|  ...|...|..|......|.           :.:
Human    72 MSQ-GPIAMQAGIPMGPMPAAGMPYLGQAPFLGMRPPGPQYTPDMQKQFAE-----------EQQ 124

  Fly   139 QLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIW-DLADQDKD-------GNLDMHEFVVAMH 195
            :.||.   ...:|...:.:....:.|..:.:|.::. ...::.:|       ||||.......||
Human   125 KRFEQ---QQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKSRDDALEAIKGNLDGFSRDAKMH 186

  Fly   196 LVYQTLQK-----------RTI---PSVLPPE-----LRKPGGAGPPPKPAMPPPPAGAAMPRAP 241
            ....:..|           :|:   |:.|..|     ::.|... ||..|:....|..:..|..|
Human   187 PTPASHPKKPDCPTSSHSTKTVSPSPAFLDEEEFSDFMQGPVEV-PPCGPSSTSQPFQSFHPSTP 250

  Fly   242 SGEGFGDGGFVANFPKDIAP-PAAIPPLPVAVPPMT------RIPPVG-AVSSQPLIQTDPLIPI 298
            .|:...........|...:| |.|:..:|..:|..:      .:|..| ::..:.|:..|.....
Human   251 LGQLHTQKAGTQPLPPSQSPVPFALHGVPGQIPYFSTASASHSVPEAGPSLEEKFLVSCDISTSG 315

  Fly   299 GAPVMANADWV----VTPADLKRFEEIFRQSDLDKDGLVSG-------------LEVKD------ 340
            ...:..|...|    :.|...|::..:...:.:..||.|||             |.:::
Human   316 QEQIKLNTSEVGHKALGPGSSKKYPSLMASNGVAVDGCVSGTTTAEAENTSDQNLSIEESGVGVF 380

  Fly   341 --------------------------------------------IFIKSGIPQRSLADIWALCDT 361
                                                        |.:.||:|:.:|..||||.:.
Human   381 PSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANR 445

  Fly   362 NQSGKLTVEQFALAMWFVERKQRGVD--PPHVLN------------------------------- 393
            ...||||.|:....:..:...||||.  .|..||
Human   446 TTPGKLTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGP 510

  Fly   394 ANMVPPSMRATVAGVDL----------QPQEVKPTYSNPELEMISKEIEELARERRVLETEIAQK 448
            |..:|.|:...|.|::|          ......|||  |..:::..|.::.            |.
Human   511 AGSMPLSLGQPVMGINLVGPVGGAAAQASSGFIPTY--PANQVVKPEEDDF------------QD 561

  Fly   449 EADVRIKNGEVRSLQSELDTLTATLKQLENQRGEA----------QKRLDDLQAQVSHNTAVLAN 503
            ..|.. |:|.:....|:...|.|:.|...:|.|.:          .|.|..:.     ..||...
Human   562 FQDAS-KSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMD-----KYAVFKG 620

  Fly   504 VSLDISRTNEQVTKIRDQCHMQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLT 568
            ::.|.|..|               |:  ..|:...|.|..::|         |..:.|:.|.:
Human   621 IAADKSSEN---------------TV--PPGDPGDKYSAFREL---------EQTAENKPLGE-- 657

  Fly   569 NHLQATQLQISSVRSMVTQLLETQRQMTDALLICRAAMENQNAELVSEYQLKIEPDFDEARKTLT 633
                    ..:..||     ..|....||.          :.|:.||    .:||.        |
Human   658 --------SFAEFRS-----AGTDDGFTDF----------KTADSVS----PLEPP--------T 687

  Fly   634 KEVQLPKDDP---FEENNSGAANQATNGFGSDPFSGQPVNKPAISTGFDDSFNMSSGFDSGFDAF 695
            |:...|...|   .::..........|....|.||       :::...:...:.|:.|.:.....
Human   688 KDKTFPPSFPSGTIQQKQQTQVKNPLNLADLDMFS-------SVNCSSEKPLSFSAVFSTSKSVS 745

  Fly   696 GQSGAGSAFGQTQRDPFGSDAFAANKSNAITPEPGKDDFGSDPFAALHAPTGQGQVLSPNAQKSG 760
            .....|||...|        |.||.|::::.     ||||.               .|...:.||
Human   746 TPQSTGSAATMT--------ALAATKTSSLA-----DDFGE---------------FSLFGEYSG 782

  Fly   761 PPPRPESPSPALPPKKSKVPPPRPAPPRAAQPTGGFGSGGGGGFADFDDFDNKLHHIPSAPSPSA 825
            ..|..|...                                  ||||..|.|.  .|.|...|
Human   783 LAPVGEQDD----------------------------------FADFMAFSNS--SISSEQKP-- 809

  Fly   826 TALSPLPPTLPAPIPVVSGSSLLDSFTLFDDPGQIHKQAASTPNPTPITVPTVHTLLQTSLSTPA 890
                                         ||.....|:.||   |.|:|.....|:.....||.|
Human   810 -----------------------------DDKYDALKEEAS---PVPLTSNVGSTVKGGQNSTAA 842

  Fly   891 APS-PALASLSTSGSG-SVAGAGADLPSSVTITTAPSLNNQHLSRSNTPLQNQRTADVKLETKAV 953
            :.. .....||..||| .|.....:.||..:.......::...|..|        :|..|..|||
Human   843 STKYDVFRQLSLEGSGLGVEDLKDNTPSGKSDDDFADFHSSKFSSIN--------SDKSLGEKAV 899

  Fly   954 VSVFDAFGEIGTRKAPTPSL----ITGPTDFKDDPFKDYRYEDPFSIKDPFAEEGEEELSEGKGA 1014
                 ||.......|...||    |.|.:..|:|.      ||..|::           .:.|.|
Human   900 -----AFRHTKEDSASVKSLDLPSIGGSSVGKEDS------EDALSVQ-----------FDMKLA 942

  Fly  1015 DHKRNFAEDFSSGDEIGSAAKTLSNIVNNNSI--------KPKAATPLNNDLLQQFDAFNLNSSP 1071
            |         ..||        |.::::::|:        .|.||.  ..||  ::.||.
Human   943 D---------VGGD--------LKHVMSDSSLDLPTVSGQHPPAAD--IEDL--KYAAFG----- 981

  Fly  1072 APSHHSGTSYHSNSKPSHDSQTALDAFADFDDFAAT---------LATTGGSGAATTATTTGNTK 1127
                    ||.||...|  :.|:.| ::|.||  ||         |:...||.:||:......|.
Human   982 --------SYSSNFAVS--TLTSYD-WSDRDD--ATQGRKLSPFVLSAGSGSPSATSILQKKETS 1033

  Fly  1128 LNNSFFDAFNDNFSVIQSSSVPTGVVR------------------PNDQRAKAFDAFNDNFED-- 1172
            ..:|      :|.::...|.|.|.|..                  |.....|.::  |.:::|
Human  1034 FGSS------ENITMTSLSKVTTFVSEDALPETTFPALASFKDTIPQTSEQKEYE--NRDYKDFT 1090

  Fly  1173 ----------QFKTSPNANFAKFDGFEAHNFSSDFGNASFGTTGKEKQNGQVDKKFQSKEPVKDK 1227
                      |..|.|:...:.......:..|.|||                  :|||::|...|
Human  1091 KQDLPTAERSQEATCPSPASSGASQETPNECSDDFG------------------EFQSEKPKISK 1137

  Fly  1228 F----AADYSKPES-----------FDADLEEALKRSV 1250
            |    |...||.:|           ||..::.:.|||:
Human  1138 FDFLVATSQSKMKSSEEMIKSELATFDLSVQGSHKRSL 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	1/2 (50%)
		EH	126..215	CDD:197477	17/115 (15%)
		EH	137..202	CDD:238009	12/72 (17%)
		EH	307..402	CDD:197477	33/194 (17%)
		EH	318..384	CDD:238009	20/128 (16%)
		RILP-like	<445..548	CDD:304877	22/112 (20%)
		Spc24	529..>584	CDD:285486	8/54 (15%)
SYNRG	XP_016879565.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0998
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900