DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eps-15 and eps15

DIOPT Version :9

Sequence 1:	NP_611965.2	Gene:	Eps-15 / 37961	FlyBaseID:	FBgn0035060	Length:	1253	Species:	Drosophila melanogaster
Sequence 2:	NP_001120100.2	Gene:	eps15 / 100145116	XenbaseID:	XB-GENE-6070905	Length:	976	Species:	Xenopus tropicalis

Alignment Length:	1138	Identity:	328/1138 - (28%)
Similarity:	492/1138 - (43%)	Gaps:	297/1138 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VYEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSL 79
            |||.|:..::...:|.:.:..||.|||:|||:|:||.:||||:|...||.|:|..|||||:||:.
Frog    17 VYEKYFHQLESGSSGKVLSSDAAFFLKRSGLADLVLGKIWDLADTDCKGHLNKQEFFVALQLVAC 81

  Fly    80 SQAGQVASMANI-------YLDIANPPKLGELPKTMPSRIQTVPVASGGVANGDWSIGVIDRLKY 137
            :|.|....::::       ..|..:||..|....|      .:|          |::...::.||
Frog    82 AQNGMEVCLSSLKAVVPPPRFDAGSPPLFGTAVTT------DIP----------WAVKPDEKAKY 130

  Fly   138 EQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQ 202
            :.:|:||:|.||.|.|:|||.||::|||.:.|||.:|:|:|.|.||.||..||.|||.|||..|:
Frog   131 DAIFDSLNPVNGFLSGDKVKPVLLNSKLSVEILGRVWELSDIDHDGLLDRDEFAVAMFLVYSALE 195

  Fly   203 KRTIPSVLPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAAIPP 267
            |..:|..||..|        .|:.......:.|::|                         .||.
Frog   196 KEPVPMSLPHTL--------VPQSKRKVSISSASLP-------------------------VIPT 227

  Fly   268 LPVAVPPMTR----IPPVGAVSSQPLIQTDPLIPIGAPVMANADWVVTPADLKRFEEIFRQSDLD 328
            ||  :||...    :||||            ::|....|   ..|||:.|:..:.:|:|.:.|.|
Frog   228 LP--MPPSKESRQSLPPVG------------ILPTKVQV---TQWVVSHAEKTKCDELFHKLDKD 275

  Fly   329 KDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERK-QRGVDPPHVL 392
            .|||||||||::||:|:|:|...||.||.||||...|||:.||||||..|:.:| .:|||||.||
Frog   276 MDGLVSGLEVREIFLKTGLPSVLLAHIWTLCDTKDCGKLSKEQFALAFHFINQKIVKGVDPPRVL 340

  Fly   393 NANMVPPSMRATVAGVDLQPQEVKPTYSNP--------ELEMISKEIEELARERRVLETEIAQKE 449
            ...|:|||.|.....|        ||.|:|        ||:.::.||.||.||:..:|.|:::||
Frog   341 TPEMMPPSERNAATKV--------PTASSPVADFSAIKELDSLNNEIVELQREKTSVEQELSEKE 397

  Fly   450 ADVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNEQ 514
            ..|:.:.|||:.||.|::..|..|:.|::|:.|.|:.|.:|..|.:...:.|..:.|..:...:.
Frog   398 DAVKCRTGEVQDLQDEVERETINLQNLKSQKQEVQEILAELDEQKAKLESQLQELRLKCAEETQM 462

  Fly   515 VTKIRDQCHMQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQIS 579
            :..::.:...||..|:..|.||:..:|||.:|::|...|::..::..:.|:.|...||.::|:|.
Frog   463 IASLKVEITTQETQISNYEDELSKAKSELNRLQEETILLEENLETGKQRLAPLEQQLQESKLEIC 527

  Fly   580 SVRSMVTQLLETQRQMTDALLIC---------RAAMENQNAELVS-------------EYQLKIE 622
            ||::.:.:|..::..: :.|..|         .:::.|.::|..:             ::|.:..
Frog   528 SVQAKLEELKASENNV-EQLNWCHHLVNGIGDHSSLSNSSSEPTNLHENTGCDSPGQLDHQSRSS 591

  Fly   623 P-------------DFDEARKTLT-----KEVQLPKDDPFEEN-----NSGAANQATNGFGSDPF 664
            |             |.:|....:.     |||.. :.||::.|     ::...:...:.|.||||
Frog   592 PVRSSPEINQTSGSDGEEKDDNVNALVPQKEVSF-QVDPYDVNPVAPPSAPVQDPGLDFFQSDPF 655

  Fly   665 SGQPVNKPAISTGFDDSFNMSSGFDSGFDAFGQSGAGSA---FGQTQRDPFGS--------DAFA 718
            .|....|       ||.|.....|  |.|.|..|...::   |.|...|||.|        |.|:
Frog   656 VGSDPFK-------DDPFGKIDPF--GGDPFKDSDPFASDVFFKQASADPFASSKVDSSKEDLFS 711

  Fly   719 ANKSNAITPEPGKDDFGSDPFAALHAPTGQGQVLSPNAQKSGPPPRPESPSPALPPKKSKVPPPR 783
            .:|:::.|..      .:|||.:..|.:    :.|..|.       |..||.|.|.|.|:..|..
Frog   712 KSKADSFTSS------NADPFVSSKAES----LTSSKAD-------PFQPSSADPFKSSEQDPFT 759

  Fly   784 PA---PPRAAQPT---------------GG------------------FGSGG-GGGFADFDDFD 811
            .|   |..|.:.|               ||                  |||.. |.|||||
Frog   760 SAKVDPFLATESTFSSEDTLKNNDPFAPGGTVVSAVSESGSEDPFASFFGSESIGTGFADF---- 820

  Fly   812 NKLHHIPSAPSPSATALSPLPPTLPAPIPVVSGSSLLDSFTLF-DDPGQIHKQAASTPNPTPITV 875
                   |..|.::|      .|..|.:|:....||  :..:| |||.|..:...:.|..|
Frog   821 -------SLLSKTST------DTFDATLPIKDKESL--NKAIFEDDPTQKEEVPPALPPKT---- 866

  Fly   876 PTVHTLLQTSLSTPAAPSPALASLSTSGSGSVAGAGADLPSSVTITTAPSLNNQHLSRSNTPLQN 940
                       .||..|.|.              .....|||   .||.|.|   |.|...|.|:
Frog   867 -----------GTPTRPCPL--------------PPGKRPSS---RTAESSN---LFRQGDPFQH 900

  Fly   941 QRTADVKLETKAVVSVFDAFGEIGTRKAPTPSLITGPTDFKDDPFKDYRYEDPFSIKDPFAEEGE 1005
            ...:..|   :.:...||      ..||.:.|          |.|..|:.||...   .:|:...
Frog   901 FSQSFYK---ETLSDPFD------VNKATSES----------DNFSTYQSEDDMI---EWAKRES 943

  Fly  1006 EELSEGKGADHKRNFAEDFS-----SGDEIGSA 1033
            |:..|.:.|..|:...||..     |..||..|
Frog   944 EKEEEERLARLKQQEQEDLELAIALSKSEISEA 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	31/65 (48%)
		EH	126..215	CDD:197477	43/88 (49%)
		EH	137..202	CDD:238009	36/64 (56%)
		EH	307..402	CDD:197477	52/95 (55%)
		EH	318..384	CDD:238009	37/66 (56%)
		RILP-like	<445..548	CDD:304877	30/102 (29%)
		Spc24	529..>584	CDD:285486	18/54 (33%)
eps15	NP_001120100.2	EH	10..102	CDD:197477	34/84 (40%)
		EH	18..84	CDD:238009	31/65 (48%)
		EH	119..213	CDD:197477	46/111 (41%)
		EH	130..195	CDD:238009	36/64 (56%)
		EH	254..350	CDD:197477	52/95 (55%)
		EH	266..329	CDD:238009	36/62 (58%)
		End3	<356..495	CDD:289527	44/146 (30%)
		TPR_MLP1_2	370..507	CDD:285204	42/136 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6493
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1615
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D360276at33208
OrthoFinder	1	1.000	-	-		FOG0001628
OrthoInspector	1	1.000	-	-		otm48118
Panther	1	1.100	-	-	LDO	PTHR11216
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R396
SonicParanoid	1	1.000	-	-		X924
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100