Protein Alignment GstE12 and CLIC3

DIOPT Version :10

• Sequence 1: NP_611964.1
• Gene: GstE12 / 37960
• FlyBaseID: FBgn0027590
• Length: 223
• Species: Drosophila melanogaster
• Sequence 2: NP_004660.2
• Gene: CLIC3 / 9022
• HGNCID: 2064
• Length: 236
• Species: Homo sapiens
• Alignment Length: 200
• Identity: 47/200 - (23%)
• Similarity: 68/200 - (34%)
• Gaps: 58/200 - (28%)

  Fly    36 LLKGEHLT---------PEFLK-LNPQHTIPTLIDGEATIIDSHAICAYLVEKYGQKEQQLYPKE 90
            ||||...|         |:.|| ..|...:|.|:.......|:..|..:|.|..|..:   :| .
Human    33 LLKGVPFTLTTVDTRRSPDVLKDFAPGSQLPILLYDSDAKTDTLQIEDFLEETLGPPD---FP-S 93

  Fly    91 LVQRANVDARLHLDSGHLFARLRFLYEPI------LYYGSTDCSIDKIAYIQKCWEILEGFLKDQ 149
            |..|.........|..|.|:  .|:..|:      ||...........:|::   ..||..|..:
Human    94 LAPRYRESNTAGNDVFHKFS--AFIKNPVPAQDEALYQQLLRALARLDSYLR---APLEHELAGE 153

  Fly   150 P--------YLCGSDLTIADFCAVATVTSVNDT-------API-----------------DEFKF 182
            |        :|.|..||:|| |::.....:.||       |||                 .|||:
Human   154 PQLRESRRRFLDGDRLTLAD-CSLLPKLHIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKY 217

  Fly   183 PKMHA 187
            ...|:
Human   218 TCPHS 222

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GstE12	NP_611964.1	GST_N_Delta_Epsilon	4..77	CDD:239343	14/50 (28%)
		GST_C_Delta_Epsilon	92..210	CDD:198287	29/133 (22%)
CLIC3	NP_004660.2	Required for insertion into the membrane. /evidence=ECO:0000250	1..88		15/54 (28%)
		O-ClC	5..229	CDD:129941	47/199 (24%)
		G-site. /evidence=ECO:0000305|PubMed:28198360, ECO:0000305|PubMed:37759794	22..25