DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GstE12 and GDAP1

DIOPT Version :9

Sequence 1:	NP_001246500.1	Gene:	GstE12 / 37960	FlyBaseID:	FBgn0027590	Length:	223	Species:	Drosophila melanogaster
Sequence 2:	NP_061845.2	Gene:	GDAP1 / 54332	HGNCID:	15968	Length:	358	Species:	Homo sapiens

Alignment Length:	285	Identity:	63/285 - (22%)
Similarity:	97/285 - (34%)	Gaps:	99/285 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KPALYYATLSPPSRAVLLTAKAIGLDLELRPINLLKGEHLTPEFLKLNPQHTIPTLIDGEATIID 67
            |..||:.|.|..|:.|.|......|..|...::|...||..|.|::||....:|.||.||..|.:
Human    25 KLILYHWTHSFSSQKVRLVIAEKALKCEEHDVSLPLSEHNEPWFMRLNSTGEVPVLIHGENIICE 89

  Fly    68 SHAICAYLVEKY---------GQKEQQLYP-----KELVQRANVDARLH---------LDS---G 106
            :..|..||.:.:         ..||...||     :||:....:||..|         :||   .
Human    90 ATQIIDYLEQTFLDERTPRLMPDKESMYYPRVQHYRELLDSLPMDAYTHGCILHPELTVDSMIPA 154

  Fly   107 HLFARLRFLYEPILYYGSTDCSIDKIA----------------------------YIQKCWEILE 143
            :...|:|      ...|:|:..:.|:|                            |::|..:.||
Human   155 YATTRIR------SQIGNTESELKKLAEENPDLQEAYIAKQKRLKSKLLDHDNVKYLKKILDELE 213

  Fly   144 GFLK-----------------DQPYLCGSDLTIADFCAVATVTSVNDTAPIDEFKF--------- 182
            ..|.                 .||:|||...|:||.....|         :...||
Human   214 KVLDQVETELQRRNEETPEEGQQPWLCGESFTLADVSLAVT---------LHRLKFLGFARRNWG 269

  Fly   183 ----PKMHAWLKRLAELPYYQEVNG 203
                |.:..:.:|:.:...:.:|.|
Human   270 NGKRPNLETYYERVLKRKTFNKVLG 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GstE12	NP_001246500.1	GST_N_Delta_Epsilon	4..77	CDD:239343	25/72 (35%)
		GstA	6..201	CDD:223698	60/278 (22%)
		GST_C_Delta_Epsilon	92..210	CDD:198287	31/182 (17%)
GDAP1	NP_061845.2	GST_N_GDAP1	26..98	CDD:239350	24/71 (34%)
		GST_C_GDAP1	179..289	CDD:198336	18/118 (15%)
		Required for mitochondrial localization	320..358
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154577
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840