DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3894 and NEURL1

DIOPT Version :9

Sequence 1:	NP_611963.5	Gene:	CG3894 / 37959	FlyBaseID:	FBgn0035059	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	XP_011538633.1	Gene:	NEURL1 / 9148	HGNCID:	7761	Length:	612	Species:	Homo sapiens

Alignment Length:	279	Identity:	69/279 - (24%)
Similarity:	108/279 - (38%)	Gaps:	86/279 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 PIGSLECAPTLSSRKRQLSRFHPY-HGSNIQLGDDATVAYRRASFADALTFSERPLAPGDIFLVE 108
            |.|.|...|.|         |||: .||.|.:........|:|||.:|:|||.||:...:...::
Human    92 PSGGLPATPLL---------FHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLK 147

  Fly   109 IEKIERGWSGHMRLGLTELAPNVIRTSSEGLPHFALPDLANLGNSWIYPISKFEMNQRQDANDII 173
            |.|.:..|||.:|||.|...|:  |...:.||.:|.|||.:....|...:.:...|:    .:||
Human   148 ITKKQCCWSGALRLGFTSKDPS--RIHPDSLPKYACPDLVSQSGFWAKALPEEFANE----GNII 206

  Fly   174 EPETDDAPHRNLLGDATHVRTPRGLLPKRLLRPAMGNGNDSDILLTDKGSRIGIIYVPTVQSDSK 238
            ....|                .:|.:..|:        |||.::|...|.|
Human   207 AFWVD----------------KKGRVFHRI--------NDSAVMLFFSGVR-------------- 233

  Fly   239 GELHFIINGVDRGPVSRDIPLNRAPLFVVIDVYGTTKQIRIIQLEGIL--SLQ----SACRNVIL 297
                                 ...||:.::||||.|:.::::..|.:|  .|:    :|.|...|
Human   234 ---------------------TADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSL 277

  Fly   298 ESFAEDA-----ISELPLP 311
            ...|:||     :.:|.:|
Human   278 RREADDARLSVSLCDLNVP 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3894	NP_611963.5	SPRY_NHR_like	64..280	CDD:293945	53/216 (25%)
CG3894	NP_611963.5	SOCS_SOCS_like	283..321	CDD:239687	11/40 (28%)
NEURL1	XP_011538633.1	NEUZ	99..221	CDD:128856	42/160 (26%)
		SPRY	103..251	CDD:295394	53/212 (25%)
		Neuralized	103..168	CDD:284568	25/64 (39%)
		NEUZ	330..452	CDD:128856
		SPRY	333..484	CDD:295394
		Neuralized	334..400	CDD:284568
		zf-C3HC4_3	556..605	CDD:290631
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810