DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3894 and neurl4

DIOPT Version :9

Sequence 1:	NP_611963.5	Gene:	CG3894 / 37959	FlyBaseID:	FBgn0035059	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	XP_021335985.1	Gene:	neurl4 / 555331	ZFINID:	ZDB-GENE-100318-4	Length:	1588	Species:	Danio rerio

Alignment Length:	305	Identity:	78/305 - (25%)
Similarity:	121/305 - (39%)	Gaps:	76/305 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PAALCAP----------SRAAYAAAEQEDPDPDQEQDRGRESPI----GSLECAPTLSSRKRQLS 63
            |||...|          .:||.|....:..|.....|...|.|.    || .|:.:.::....|
Zfish   689 PAAWNVPPNVYAVVDLYGQAAQATIMDDMADLPPLPDDSSEGPTAMSPGS-PCSISGATAANDL- 751

  Fly    64 RFHPYHGSNIQLGDDATVAYR---RASFADALTFSERPLAPGDIFLVEIEKIERGWSGHMRLGLT 125
            |||..||:|..:.:....|.|   |:.|.||:..|.|.|..|::|.:.|:|:...|||.:..|:|
Zfish   752 RFHQLHGTNAVITNGGRTALRQNCRSEFNDAIVISNRCLREGELFEIVIQKMVDRWSGSIEAGVT 816

  Fly   126 ELAPNVIRTSSEGLPHFALPDLANLGNSWIYPISKFEMNQRQDANDIIEPETDDAPHRNLLGDAT 190
            .:.|..:.     .|: .:.|:..  ::|:...:..    .||.|.:          ||
Zfish   817 AIRPEELE-----FPN-TMTDIDY--DTWMLSGTAI----MQDGNTM----------RN------ 853

  Fly   191 HVRTPRGLLPKRLLRPAMGNGNDSDILLTDKGSRIGIIYVPTVQSDSKGELHFIINGVDRGPVSR 255
                              ..|.|.|.|.|  .||||::...|      |:||:.|||:|:|....
Zfish   854 ------------------NYGCDLDSLTT--ASRIGMMRTAT------GDLHYFINGLDQGVACT 892

  Fly   256 DIPLNRAPLFVVIDVYGTTKQIRIIQLEGILSLQSACRNVILESF 300
            .:|   :.::.|:|:||...|:.|....|.|.......|:..:||
Zfish   893 GLP---SEVYAVVDLYGQCVQVSITSSSGPLDNSLCTSNITEKSF 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3894	NP_611963.5	SPRY_NHR_like	64..280	CDD:293945	57/218 (26%)
CG3894	NP_611963.5	SOCS_SOCS_like	283..321	CDD:239687	5/18 (28%)
neurl4	XP_021335985.1	SPRY_NHR_like	4..166	CDD:293945
		SPRY_NHR_like	347..509	CDD:293945
		SPRY_NHR_like	553..713	CDD:293945	7/23 (30%)
		SPRY_NHR_like	752..914	CDD:293945	57/218 (26%)
		SPRY_NHR_like	946..1112	CDD:293945
		SPRY_NHR_like	1158..1317	CDD:293945
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D491552at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820