DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3894 and Neurl1b

DIOPT Version :9

Sequence 1:	NP_611963.5	Gene:	CG3894 / 37959	FlyBaseID:	FBgn0035059	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_001075125.1	Gene:	Neurl1b / 240055	MGIID:	3643092	Length:	546	Species:	Mus musculus

Alignment Length:	309	Identity:	71/309 - (22%)
Similarity:	113/309 - (36%)	Gaps:	111/309 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LDEAAAPAALCAPSRAAYAAAEQEDPDPDQEQDRGRESPIGSLECAPTLSSRKRQLSRFHPY-HG 70
            |.:::.||.|.| :|..|.      |.|::....| |:|                  |||.. .|
Mouse     9 LPDSSPPARLLA-TRPCYG------PGPERRAVLG-EAP------------------RFHAQAKG 47

  Fly    71 SNIQLGDDATVAYRRASFADALTFSERPLAPGDIFLVEIEKIERGWSGHMRLGLTELAPNVIRTS 135
            .|::|...:..|.||.||.:.:||::||:...:...:.:..:..||||.:|.|.|...|:::  |
Mouse    48 KNVRLDGHSRRATRRNSFCNGVTFTQRPIRLYEQVRLRLVAVRPGWSGALRFGFTAHDPSLM--S 110

  Fly   136 SEGLPHFALPDLANLGNSWIYPISKFEMNQRQDANDIIEPETDDAPHRNLLGDATHVRTPRGLLP 200
            ::.:|.:|.|||......|                                         ...||
Mouse   111 AQDIPKYACPDLVTRPGYW-----------------------------------------AKALP 134

  Fly   201 KRL-LRPAMGNGNDSDILLTDKGSRIGIIYVPTVQSDSKGELHFIINGVDRGPVSRDIPLNRAPL 264
            :.| ||         |.:|.....|.|.::    .|.:.||......||..|          .||
Mouse   135 ENLALR---------DTVLAYWADRHGRVF----YSVNDGEPVLFHCGVAVG----------GPL 176

  Fly   265 FVVIDVYGTTKQIRIIQLEGILSLQSACRNVILESFAEDAISELPLPES 313
            :.:|||||.|.:::                 :|||...|.::.|.|.::
Mouse   177 WALIDVYGITDEVQ-----------------LLESTFADTLTPLRLGQA 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3894	NP_611963.5	SPRY_NHR_like	64..280	CDD:293945	53/217 (24%)
CG3894	NP_611963.5	SOCS_SOCS_like	283..321	CDD:239687	6/31 (19%)
Neurl1b	NP_001075125.1	SPRY	40..189	CDD:295394	53/214 (25%)
		NEUZ	40..159	CDD:128856	40/174 (23%)
		Neuralized	41..106	CDD:284568	21/64 (33%)
		NEUZ	271..390	CDD:128856
		Neuralized	273..338	CDD:284568
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..490
		zf-C3HC4_3	490..540	CDD:290631
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810