DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3894 and Neurl3

DIOPT Version :9

Sequence 1:	NP_611963.5	Gene:	CG3894 / 37959	FlyBaseID:	FBgn0035059	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	XP_006495909.1	Gene:	Neurl3 / 214854	MGIID:	2429944	Length:	268	Species:	Mus musculus

Alignment Length:	277	Identity:	66/277 - (23%)
Similarity:	101/277 - (36%)	Gaps:	83/277 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RGRESP---IGSLECAPTLSSRKRQLSRFHPYHGSNIQLGDDATVAYRRASFADALTFSERPLAP 101
            |.||..   :|.|.........:..||......|:.:.|.|..:.|.||::|.|.:.||:||:.|
Mouse     7 RSREESRAIVGHLRGMHNAEVPREALSFHGNATGAQVHLDDQRSTARRRSTFHDGIVFSQRPVWP 71

  Fly   102 GDIFLVEIEKIERGWSGHMRLGLTELAPNVIRTSSEGLPHFALPDLANLGNSWIYPISKFEMNQR 166
            |:...:.:.:.|.||.|.:|:|.|.|.|..:..|.  ||.|..|||.....:|
Mouse    72 GERVALRVLRHEEGWCGGLRVGFTRLDPAQVAASC--LPPFVCPDLEEQSPTW------------ 122

  Fly   167 QDANDIIEPETDDAPHRNLLGDATHVRTPRGLLPKRLLRPAMGNGNDSDILLTDKGSRIGIIYVP 231
                                         ..|||:..:|.    ||                 |.
Mouse   123 -----------------------------AALLPEGFVRA----GN-----------------VV 137

  Fly   232 TVQSDSKGELHFIINGVDRGPVSRDIPLNRAPLFVVIDVYGTTKQIRIIQLEGILSLQSACRNVI 296
            ....:.:|.|...:|......:.:|:.:..|||:.|:|||||||.|.::..:....::|.
Mouse   138 CFWVNRRGWLFAKVNAGRPLLLRKDVLVQGAPLWAVMDVYGTTKAIELLDPKANAWIRSG----- 197

  Fly   297 LESFAEDAISELPLPES 313
                       .|:|||
Mouse   198 -----------EPVPES 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3894	NP_611963.5	SPRY_NHR_like	64..280	CDD:293945	54/215 (25%)
CG3894	NP_611963.5	SOCS_SOCS_like	283..321	CDD:239687	5/31 (16%)
Neurl3	XP_006495909.1	Neuralized	34..187	CDD:369249	54/216 (25%)
Neurl3	XP_006495909.1	RING-HC_NEURL3	209..250	CDD:319466
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810