DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3894 and NEURL2

DIOPT Version :9

Sequence 1:	NP_611963.5	Gene:	CG3894 / 37959	FlyBaseID:	FBgn0035059	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_542787.1	Gene:	NEURL2 / 140825	HGNCID:	16156	Length:	285	Species:	Homo sapiens

Alignment Length:	292	Identity:	112/292 - (38%)
Similarity:	154/292 - (52%)	Gaps:	40/292 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GRESPIGSLECAPTLSSRKRQLSRFHPYHGSNIQLGDDATVAYRRASFADALTFSERPLAPGDIF 105
            |.|.|    |..||         |||..||:||::....|.|.|..|||..:.||..|||||.:|
Human    15 GLERP----EPPPT---------RFHRVHGANIRVDPSGTRATRVESFAHGVCFSREPLAPGQVF 66

  Fly   106 LVEIEKIERGWSGHMRLGLTELAPNVIRTSSEGLPHFALPDLANLGNSWIYPISKFEMNQRQDAN 170
            |||||:.|.||.||:|||||.|.|    .|...:|.|:||||.|||::|::.|::......::..
Human    67 LVEIEEKELGWCGHLRLGLTALDP----ASLAPVPEFSLPDLVNLGHTWVFAITRHHNRVPREGR 127

  Fly   171 DIIEPETDDAPHRNLLGDATHV---RTPRGLLPKRLLRPAMGNGNDSDIL----------LTDKG 222
            ...|......|...|:.....:   |.||..|..| .||    |..|.:|          .|.:.
Human   128 PEAEAAAPSRPPTLLVEPYLRIEQFRIPRDRLVGR-SRP----GLYSHLLDQLYELNVLPPTARR 187

  Fly   223 SRIGIIYVPTVQSDSKGELHFIINGVDRGPVSRDIPLNRAPLFVVIDVYGTTKQIRIIQLE-GIL 286
            ||:|:::.|  :.|...::|.||||.|.||.:|.:|..: ||:.|:||:.:||.:|::||| |:.
Human   188 SRLGVLFCP--RPDGTADMHIIINGEDMGPSARGLPAAQ-PLYAVVDVFASTKSVRLVQLEYGLP 249

  Fly   287 SLQSACRNVILESFAED-AISELPLPESIKRF 317
            |||:.||.||..|.... ||..|.||:.:|.|
Human   250 SLQTLCRLVIQRSMVHRLAIDGLHLPKELKDF 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3894	NP_611963.5	SPRY_NHR_like	64..280	CDD:293945	87/228 (38%)
CG3894	NP_611963.5	SOCS_SOCS_like	283..321	CDD:239687	17/37 (46%)
NEURL2	NP_542787.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		3/8 (38%)
		SPRY_NHR_like	25..242	CDD:293945	87/228 (38%)
		SOCS_box	249..285	CDD:198037	15/33 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4808
eggNOG	1	0.900	-	-		E1_KOG4625
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15435
Inparanoid	1	1.050	164	1.000	Inparanoid score	I4203
Isobase	1	0.950	-	0	Normalized mean entropy	S6243
OMA	1	1.010	-	-		QHG48960
OrthoDB	1	1.010	-	-		D1185754at2759
OrthoFinder	1	1.000	-	-		FOG0008119
OrthoInspector	1	1.000	-	-		oto88626
orthoMCL	1	0.900	-	-		OOG6_108559
Panther	1	1.100	-	-	LDO	PTHR12429
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5784
SonicParanoid	1	1.000	-	-		X6069
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820