DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp15-31 and USP15

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_001239007.1	Gene:	USP15 / 9958	HGNCID:	12613	Length:	981	Species:	Homo sapiens

Alignment Length:	1009	Identity:	265/1009 - (26%)
Similarity:	393/1009 - (38%)	Gaps:	289/1009 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ADTSTTNAAKKIRRTFSMP--RNPFRWTRKFKTAV-------AVTSSAG--------AENDNESG 97
            |||..| ..|:||:.||:|  :....|.:......       :....||        .|..||.|
Human   155 ADTIDT-IEKEIRKIFSIPDEKETRLWNKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDG 218

  Fly    98 KNNGARERRGSHTAISSCVGGGRGRSGSIVSLSSYEAPFISSTNNNTTTASNGNNNNSSSSNINS 162
                 ...||..|..|.    |.....::..:|.      ||.:||   .:|.||.|..:||.
Human   219 -----TWPRGPSTPKSP----GASNFSTLPKISP------SSLSNN---YNNMNNRNVKNSNY-- 263

  Fly   163 KRTRALRRSSFRKFLNRIAQHLSSTVNVVSEEKHSPANRIAFIEIVPFYTGCWRRKEANKHGQPS 227
                                                        .:|.||       |.|:...|
Human   264 --------------------------------------------CLPSYT-------AYKNYDYS 277

  Fly   228 VSGSSSGGGGGAGGPGGGERVPPIGGYQWPADQTPGVMGLKNHGNTCFMNAVLQCLSHTDILAEY 292
            ..|.:                          ::.||:.||.|.|||||||:.:||||:|..|.||
Human   278 EPGRN--------------------------NEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEY 316

  Fly   293 FVLDQYKADLKRRNKINSRKFGTKGELTEQLANVLKALWTCKNESDHSTSFKAVVDRYGTQFRSS 357
            |:.|:|:.:|...|.:     |.:||:.:..|.::|.:|:.|.......:||..|.|:..||...
Human   317 FLNDKYQEELNFDNPL-----GMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGY 376

  Fly   358 TQHDAQEFLFWLLDKVHEDLNTASKRRYKSLKNSYGRSDEVIAAETLANHIRCNNSFVQAVFQAQ 422
            .|.|.||.|.:|||.:|||||...|:.|..||::.||.|:|:|.|...||::.|:|.:..:|...
Human   377 QQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGL 441

  Fly   423 FRSSLTCPRCEKQSNTFDPFHCISVQLPQLTQQTIFVTVVYMTRLPRQVRMGLRVPAGSPIVALR 487
            |:|:|.||.|.|.|.|||||..:::.||...::|:.|.:|.|..|.:.::..:.||....|:.|.
Human   442 FKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLC 506

  Fly   488 EQLQADTGIEGSRMVLVDLNAEGFTRVFYDTQPVETLSSIETIYCIEVPAATPVAKAATPSETGD 552
            ..|.|.:||...:|::.|:....|.|:|...:.:.::...:.||..|:..              :
Human   507 TALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEINI--------------N 557

  Fly   553 KSAPTAVTPSPAAAQSQADLLLLVANVYRAKDGADITRFGAPFSMKAPRDCSYQDLQKRMLREMA 617
            ::..|.....|...:.:     ...:.|....|:.:  ||.||.|..||:.:...|...:|..|.
Human   558 RTEDTEHVIIPVCLREK-----FRHSSYTHHTGSSL--FGQPFLMAVPRNNTEDKLYNLLLLRMC 615

  Fly   618 PLLK------------------------PE-VFSYATPLAEMFRIRLQD--------PSADPDTY 649
            ..:|                        |. :....:| :||......|        ||.:.::.
Human   616 RYVKISTETEETEGSLHCCKDQNINGNGPNGIHEEGSP-SEMETDEPDDESSQDQELPSENENSQ 679

  Fly   650 LE-------QVEHPLLTEMIDMALSVLSS---------------------EAGPQHIK------- 679
            .|       ..|:.|.||  |.....|:.                     :...:||:
Human   680 SEDSVGGDNDSENGLCTE--DTCKGQLTGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLR 742

  Fly   680 ------LLLEWSSPEAHFISKQQDTEEAVVEHESVARLSASKPSDTAALTLEQCLEHYTKAETLS 738
                  |.|:| .|:.......::..|...:||||    ..||.....:.|:.|:|.:|..|.|.
Human   743 LDERSFLALDW-DPDLKKRYFDENAAEDFEKHESV----EYKPPKKPFVKLKDCIELFTTKEKLG 802

  Fly   739 AEDAWRCPHCQQYLPVVKTLGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFDMSPH 803
            |||.|.||:|:::....|.|.|||||.:||||.|||...:.   ...||.|:|.||:...|||..
Human   803 AEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRY---MRDKLDTLVDFPINDLDMSEF 864

  Fly   804 LARGVHESASSSLGMGTGIGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTRYDLYAVCYHQGD 868
            |.                         ||                  :|...||:|.||..|.|.
Human   865 LI-------------------------NP------------------NAGPCRYNLIAVSNHYGG 886

  Fly   869 TLETGHYTAACKNPYDRQWYKFDDQRVSKVPEDDIEQDIINNEAYMLFYQRRSVDAG-------- 925
             :..|||||..||..|.:||.|||..||...||    .|::..||:|||||:...:|
Human   887 -MGGGHYTAFAKNKDDGKWYYFDDSSVSTASED----QIVSKAAYVLFYQRQDTFSGTGFFPLDR 946

  Fly   926 ECSGSSSNSGDHWVSRIAPASSSSASSTSGKERE 959
            |..|:|:.:|       .|..|...|:.:..:.|
Human   947 ETKGASAATG-------IPLESDEDSNDNDNDIE 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	51/120 (43%)
		Peptidase_C19	266..>461	CDD:271592	81/194 (42%)
		Peptidase_C19R	<713..918	CDD:239139	71/204 (35%)
USP15	NP_001239007.1	Mediates interaction with SART3. /evidence=ECO:0000269\|PubMed:24526689	2..223		17/73 (23%)
		UBP12	12..932	CDD:227847	254/959 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..237		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..694		9/65 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	952..981		6/29 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	1	1.000	-	-		FOG0000596
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820