Protein Alignment Usp15-31 and USP2

DIOPT Version :10

• Sequence 1: NP_611959.2
• Gene: Usp15-31 / 37954
• FlyBaseID: FBgn0050421
• Length: 1272
• Species: Drosophila melanogaster
• Sequence 2: NP_004196.4
• Gene: USP2 / 9099
• HGNCID: 12618
• Length: 605
• Species: Homo sapiens
• Alignment Length: 863
• Identity: 162/863 - (18%)
• Similarity: 252/863 - (29%)
• Gaps: 380/863 - (44%)

  Fly    93 DNESGKNNGARERRGSHTAISSCVGGGRGRSGSIVSLSSYEAPFISSTNNNTTTASNGNNNNSSS 157
            |...|......:.||:...:.|.:.||.|....:.:......| |::.:...|.....::.:..:
Human    84 DITGGGKRAESQTRGTERPLGSGLSGGSGFPYGVTNNCLSYLP-INAYDQGVTLTQKLDSQSDLA 147

  Fly   158 SNINSKRT--------RALRRSSF----RKFL-------------NRIAQHL------SSTVNVV 191
            .:.:|.||        |.|.||..    ||.|             ..:..:|      .|...|.
Human   148 RDFSSLRTSDSYRIDPRNLGRSPMLARTRKELCTLQGLYQTASCPEYLVDYLENYGRKGSASQVP 212

  Fly   192 SEEKHSPANRIAFIEIVPFY--TGCWRRKEANKHGQPSVSGSSSGGGGGAGGPGGGERVPPIGGY 254
            |:   :|.:|:..| |.|.|  .|.:...|..|...|..|.|||.|..|..
Human   213 SQ---APPSRVPEI-ISPTYRPIGRYTLWETGKGQAPGPSRSSSPGRDGMN-------------- 259

  Fly   255 QWPADQTPGVMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLKRRNKINSRKFGTKGEL 319
               :....|:.||:|.|||||||::|||||:|..|.:|.:...|..||...:..::       .|
Human   260 ---SKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHT-------AL 314

  Fly   320 TEQLANVLKALWTCK-NESDHSTSFKAVVDRYGTQFRSSTQHDAQEFLFWLLDKVHEDLNTASKR 383
            .|:.|.:::.:||.. |:....:.||..:.||..:|....|.||||||.:|||.:|.::|..:.|
Human   315 VEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLR 379

  Fly   384 RYKSLKNSYGRSDEVIAAETLANHIRCNNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCISVQ 448
            ...:.:|.....|:....:....::...:|.:..:|..|.:|||||..|...|..||||..:|:
Human   380 PKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSL- 443

  Fly   449 LPQLTQQTIFVTVVYMTRLPRQVRMGLRVPAGSPIVALREQLQADTGIEGSRMVLVDLNAEGFTR 513
                                                                             
Human   444 ----------------------------------------------------------------- 443

  Fly   514 VFYDTQPVETLSSIETIYCIEVPAATPVAKAATPSETGDKSAPTAVTPSPAAAQSQADLLLLVAN 578
                                      |:||...|.
Human   444 --------------------------PIAKRGYPE------------------------------ 452

  Fly   579 VYRAKDGADITRFGAPFSMKAPRDCSYQDLQKRMLREMAPLLKPEVFSYATPLAEMFRIRLQDPS 643
                                                                             
Human   453 ----------------------------------------------------------------- 452

  Fly   644 ADPDTYLEQVEHPLLTEMIDMALSVLSSEAGPQHIKLLLEWSSPEAHFISKQQDTEEAVVEHESV 708
                                                                             
Human   453 ----------------------------------------------------------------- 452

  Fly   709 ARLSASKPSDTAALTLEQCLEHYTKAETLSAEDAWRCPHCQQYLPVVKTLGLWSLPDILVVHFKR 773
                         :||..|:..:||.:.|..::...|..|:.....:|...:...|.|||:|.||
Human   453 -------------VTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKR 504

  Fly   774 FRQHQSKGPQAAKLTTMVKFPLTAFDMSPHLARGVHESASSSLGMGTGIGLGLGLGSNPWKKARS 838
            |.:.:.:   .:||||.|.|||...|:        .|.||.:.....
Human   505 FSESRIR---TSKLTTFVNFPLRDLDL--------REFASENTNHAV------------------ 540

  Fly   839 VDSRSSTLNSRCDAKDTRYDLYAVCYHQGDTLETGHYTAACKNPYDRQWYKFDDQRVSKVPEDDI 903
                              |:||||..|.|.|: .|||||.|::|...:|:.|:|..|:.:....:
Human   541 ------------------YNLYAVSNHSGTTM-GGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQV 586

  Fly   904 EQDIINNEAYMLFYQRRS 921
            .    .::||:|||:..|
Human   587 R----TSDAYLLFYELAS 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	UBP12	<255..921	CDD:227847	120/666 (18%)
USP2	NP_004196.4	Necessary for interaction with MDM4. /evidence=ECO:0000269|PubMed:19838211	1..200		21/116 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	71..107		5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	237..264		9/43 (21%)
		UCH	267..596	CDD:425685	117/652 (18%)
		Necessary for interaction with MDM4. /evidence=ECO:0000269|PubMed:19838211	403..503		33/364 (9%)