DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usp15-31 and USP6

DIOPT Version :9

Sequence 1:NP_611959.2 Gene:Usp15-31 / 37954 FlyBaseID:FBgn0050421 Length:1272 Species:Drosophila melanogaster
Sequence 2:NP_001291213.1 Gene:USP6 / 9098 HGNCID:12629 Length:1406 Species:Homo sapiens


Alignment Length:934 Identity:207/934 - (22%)
Similarity:341/934 - (36%) Gaps:270/934 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   256 WPADQT----------------PGVMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLKR 304
            ||.:.:                .|..||.|.|||||||:.:||:|:|..|.:||:..::..:|.|
Human   507 WPEEMSFTANSSKIDRQKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNR 571

  Fly   305 RNKINSRKFGTKGELTEQLANVLKALWTCKNESDHSTSFKAVVDRYGTQFRSSTQHDAQEFLFWL 369
            .|.|     |.||.:.:...::::.||:...:|......:..:.:|..:|....|.|:||.|.:|
Human   572 TNPI-----GMKGHMAKCYGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFL 631

  Fly   370 LDKVHEDLNTASKRRYKSLKNSYGRSDEVIAAETLANHIRCNNSFVQAVFQAQFRSSLTCPRCEK 434
            ||.:|||||...::.|..||:|.||.|..:|||...||:|.|.|.:..:|..|.||.:.|..|..
Human   632 LDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGH 696

  Fly   435 QSNTFDPFHCISVQLPQLTQQTIFVTVVYMTRLPRQVRMGLRVPAGSPIVALREQLQADTGIEGS 499
            .|..||||:.:|:.||..:...:.:||:.:.. ...||.|||:........|::||:...|:...
Human   697 ISVRFDPFNFLSLPLPMDSYMDLEITVIKLDG-TTPVRYGLRLNMDEKYTGLKKQLRDLCGLNSE 760

  Fly   500 RMVLVDLNAEGFTRVFYDTQPVETLSSIETIYC-IEVPAATPVAKAATPSE-------------- 549
            :::|.:::.........|.|.|:.  |:....| .|:|..:....|::|::              
Human   761 QILLAEVHDSNIKNFPQDNQKVQL--SVSGFLCAFEIPVPSSPISASSPTQIDFSSSPSTNGMFT 823

  Fly   550 ---TGD--------KSAPTAVTP---------------SPAAAQSQADLLLLVANVYRAKDGADI 588
               .||        ...|..|.|               .|:...|.....::.  |:|.....::
Human   824 LTTNGDLPKPIFIPNGMPNTVVPCGTEKNFTNGMVNGHMPSLPDSPFTGYIIA--VHRKMMRTEL 886

  Fly   589 ----------TRFGAPFSMKAPRDCSYQDLQKRMLREMAPLLKP--------------EVFSYAT 629
                      :.||.|..:........:||...:..:::.|.:|              ....|..
Human   887 YFLSPQENRPSLFGMPLIVPCTVHTRKKDLYDAVWIQVSWLARPLPPQEASIHAQDRDNCMGYQY 951

  Fly   630 PLAEMFRIRLQDPSADPDTYLEQVEHPLLTEMIDMALSVLSSEAGPQHIKLLLEWSSPEAHFISK 694
            |    |.:|:.....:...:..|.......: ||..    ...|...:..:.::|.....|.  :
Human   952 P----FTLRVVQKDGNSCAWCPQYRFCRGCK-IDCG----EDRAFIGNAYIAVDWHPTALHL--R 1005

  Fly   695 QQDTEEAVVE-HESVARLSASKPSDTAALTLEQCLEHYTKAETLSAEDAWRCPHCQQYLPVVKTL 758
            .|.::|.||: ||||.:   |:.:....:.|:.||..:|..|.|...:.:.|..|:.:....|.|
Human  1006 YQTSQERVVDKHESVEQ---SRRAQAEPINLDSCLRAFTSEEELGESEMYYCSKCKTHCLATKKL 1067

  Fly   759 GLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFD-----------------MSPH--- 803
            .||.||..|::|.|||   |....|..|...:|:|...:||                 ::|.   
Human  1068 DLWRLPPFLIIHLKRF---QFVNDQWIKSQKIVRFLRESFDPSAFLVPRDPALCQHKPLTPQGDE 1129

  Fly   804 ------LARGVHE-------------------------------SASSSLGMGTG---------- 821
                  |||.|.:                               |.|||...||.          
Human  1130 LSKPRILAREVKKVDAQSSAGKEDMLLSKSPSSLSANISSSPKGSPSSSRKSGTSCPSSKNSSPN 1194

  Fly   822 -----IGLGLG------LGS--NPWKKARSVD-SRSSTLNSRCDAKDTR---------------- 856
                 :|...|      :||  .|....:::| |:.:.....|:..|..                
Human  1195 SSPRTLGRSKGRLRLPQIGSKNKPSSSKKNLDASKENGAGQICELADALSRGHMRGGSQPELVTP 1259

  Fly   857 ----------------------------------------------------YDLYAVCYHQGDT 869
                                                                |:|||:..|.| .
Human  1260 QDHEVALANGFLYEHEACGNGCGDGYSNGQLGNHSEEDSTDDQREDTHIKPIYNLYAISCHSG-I 1323

  Fly   870 LETGHYTAACKNPYDRQWYKFDDQRVSKVPEDDIEQDIINNEAYMLFYQRRSVDAGECSGSSSNS 934
            |..|||....||| :.:||.::|....::..|:|:.|    .||:|||:::.:|..:....... 
Human  1324 LSGGHYITYAKNP-NCKWYCYNDSSCEELHPDEIDTD----SAYILFYEQQGIDYAQFLPKIDG- 1382

  Fly   935 GDHWVSRIAPASSSSASSTSGKER 958
                 .::|..||:...|.|..|:
Human  1383 -----KKMADTSSTDEDSESDYEK 1401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp15-31NP_611959.2 Peptidase_C19 <262..>383 CDD:271592 43/120 (36%)
Peptidase_C19 266..>461 CDD:271592 71/194 (37%)
Peptidase_C19R <713..918 CDD:239139 70/353 (20%)
USP6NP_001291213.1 TBC 97..312 CDD:214540
DUF4607 <332..407 CDD:292024
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 348..380
UBP12 <528..1114 CDD:227847 154/612 (25%)
Peptidase_C19 533..>723 CDD:271592 71/194 (37%)
Peptidase_C19 <1023..1367 CDD:271592 70/352 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1120..1231 18/110 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1384..1406 6/18 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5560
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1283205at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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