Protein Alignment Usp15-31 and UBP12

DIOPT Version :9

• Sequence 1: NP_611959.2
• Gene: Usp15-31 / 37954
• FlyBaseID: FBgn0050421
• Length: 1272
• Species: Drosophila melanogaster
• Sequence 2: NP_012338.1
• Gene: UBP12 / 853242
• SGDID: S000003733
• Length: 1254
• Species: Saccharomyces cerevisiae
• Alignment Length: 1067
• Identity: 237/1067 - (22%)
• Similarity: 390/1067 - (36%)
• Gaps: 337/1067 - (31%)

  Fly   248 VPPI-GGYQWPA--------DQTPGVMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLK 303
            :.|| |.:.||:        :...|..||.|.||||:||:.||||.|...|.:||:.|.|:.::.
Yeast   338 IKPIEGNHHWPSNYFAYNKLEPASGTTGLVNLGNTCYMNSALQCLVHIPQLRDYFLYDGYEDEIN 402

  Fly   304 RRNKINSRKFGTKGELTEQLANVLKALW------TCKNESDHSTSFKAVVDRYGTQFRSSTQHDA 362
            ..|.:     |..|.:....:::::.|:      ..:|.:...:.||:.:..:.:.|....|.|:
Yeast   403 EENPL-----GYHGYVARAFSDLVQKLFQNRMSIMQRNAAFPPSMFKSTIGHFNSMFSGYMQQDS 462

  Fly   363 QEFLFWLLDKVHEDLNTASKRRYKSLKNSYGRSDEV--------IAAETLANHIRCNNSFVQAVF 419
            ||||.:|||.:|||||...|:.|.. |.|....|:|        :|.:|...|::.|.|.:..:|
Yeast   463 QEFLAFLLDSLHEDLNRIIKKEYTE-KPSLSPGDDVNDWNVVKKLADDTWEMHLKRNCSVITDLF 526

  Fly   420 QAQFRSSLTCPRCEKQSNTFDPFHCISVQLPQLTQQTIFVTVVYMTRLPRQVRMGLRVPAGSPIV 484
            ...::|:|.||.|:..|.||||::.:::.||..|.....:.:..|...|  :.:.:.:...|..:
Yeast   527 VGMYKSTLYCPECQNVSITFDPYNDVTLPLPVDTVWDKTIKIFPMNSPP--LLLEVELSKSSTYM 589

  Fly   485 ALREQLQADTGIEG---------SRMVLVDLNAEGFTRVFYDTQPVETLSSIETIYCIEVPAA-- 538
            .|:..:...:|::.         |..:.|:..:......|...|  |.:...:.:...|:|..
Yeast   590 DLKNYVGKMSGLDPNTLFGCEIFSNQIYVNYESTESNAQFLTLQ--ELIKPADDVIFYELPVTND 652

  Fly   539 ----TPVAKAATPSETGDKSA-----PTAVTPSPAAAQSQADLLLLVANVYRAKDGADI------ 588
                .||..  |..|.|.|:|     |..:|.......:...:.:.:.|.:....|..|
Yeast   653 NEVIVPVLN--TRIEKGYKNAMLFGVPFFITLKEDELNNPGAIRMKLQNRFVHLSGGYIPFPEPV 715

  Fly   589 ---TRFGAPFSMKAPRDCSYQDLQKRMLREMAPLLKPEV-------FS----------------- 626
               |.|...|.:...:   |.|::....:::......:|       ||
Yeast   716 GNRTDFADAFPLLVEK---YPDVEFEQYKDILQYTSIKVTDKDKSFFSIKILSVEKEQQFASNNR 777

  Fly   627 ----YATPLAEMFRIRLQDPSADPDTYLEQVEHPL--LTEMIDMALSVL----------SSEA-- 673
                :.||::::    ..|.:.|.|..||.|...:  .:.::|.|..||          .|||
Yeast   778 TGPNFWTPISQL----NLDKATDIDDKLEDVVKDIYNYSSLVDCAEGVLMQVDDEGDTEGSEAKN 838

  Fly   674 ---------------------------------------------------GPQHIK-------- 679
                                                               .|:.:.
Yeast   839 FSKPFQSGDDEENKETVTNNENVNNTNDRDEDMELTDDVEEDASTEPELTDKPEALDKIKDSLTS 903

  Fly   680 -----------LLLEWS---SPEAHFISKQQDTEE-AVVEHESV--ARLSASKPSDTAALTLEQC 727
                       ::.|||   |.||....|..:.|. |.:.::.:  |:|..|...: ..:||:.|
Yeast   904 TPFAILSMNDIIVCEWSELGSNEAFSDDKIYNWENPATLPNKELENAKLERSNAKE-RTITLDDC 967

  Fly   728 LEHYTKAETLSAEDAWRCPHCQQYLPVVKTLGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVK 792
            |:.::|.|.|...|:|.||.|:::....|.:.||:.||||::|.|||...:|   .:.|:...|.
Yeast   968 LQLFSKPEILGLTDSWYCPTCKEHRQATKQIQLWNTPDILLIHLKRFESQRS---FSDKIDATVN 1029

  Fly   793 FPLTAFDMSPHLARGVHESASSSLGMGTGIGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTRY 857
            ||:|..|:|.::   |::.                                       |.:...|
Yeast  1030 FPITDLDLSRYV---VYKD---------------------------------------DPRGLIY 1052

  Fly   858 DLYAVCYHQGDTLETGHYTAACKNPYDRQWYKFDDQRVSK-VPEDDIEQDIINNEAYMLFYQRRS 921
            |||||..|.|. |..|||||..||..|.:||.|||.||:: .||:.|.     ..||:|||.||.
Yeast  1053 DLYAVDNHYGG-LGGGHYTAYVKNFADNKWYYFDDSRVTETAPENSIA-----GSAYLLFYIRRH 1111

  Fly   922 VDAGECSGSS--------SNSG-DHWVSRIAPASSSSASSTSGKEREPVKLEENTESPAAVEVTE 977
            .| |...|||        |..| |..:.:|..              |.:||.|..::....:|::
Yeast  1112 KD-GNGLGSSKLQEIIQKSRHGYDERIKKIYD--------------EQMKLYEFNKTDEEEDVSD 1161

  Fly   978 KAQSKPVDIVCQDKAKGTADGPDADQEQTTVPHDLQIEELAFADADVDTSLGETIKAEVNLAAKD 1042
            ..      |.|.:..:    .|:.......|.|
Yeast  1162 DM------IECNEDVQ----APEYSNRSLEVGH-------------------------------- 1184

  Fly  1043 EPKKVEVEEATPIFAMDEDGSEARQ-----EKKEECVKKEDELSEAPDVSELTAESKTNGHVSSS 1102
                :|.::..     |||.::..:     .:|...:||               ..|.|..:.||
Yeast  1185 ----IETQDCN-----DEDDNDDGERTNSGRRKLRLLKK---------------VYKNNSGLGSS 1225

  Fly  1103 SSSSSSESSLSSRSSPRSLSTSVTAAS 1129
            |:|..||....:..:..:|...||..|
Yeast  1226 STSEISEGCPENEVADLNLKNGVTLES 1252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	42/126 (33%)
		Peptidase_C19	266..>461	CDD:271592	66/208 (32%)
		Peptidase_C19R	<713..918	CDD:239139	65/205 (32%)
UBP12	NP_012338.1	UBP12	99..1111	CDD:227847	198/843 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3835
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000596
OrthoInspector	1	1.000	-	-		otm46646
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21646
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860