DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp15-31 and USP45

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_001073950.1	Gene:	USP45 / 85015	HGNCID:	20080	Length:	814	Species:	Homo sapiens

Alignment Length:	757	Identity:	152/757 - (20%)
Similarity:	259/757 - (34%)	Gaps:	234/757 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 VMGLKNHGNTCFMNAVLQCLSHTDILAEYF------------------VLDQYKADLKRRNKINS 310
            |.|:.|.|||||.|||:|.|:.|..|.:..                  .||....:|.|...:.|
Human   189 VRGITNLGNTCFFNAVMQNLAQTYTLTDLMNEIKESSTKLKIFPSSDSQLDPLVVELSRPGPLTS 253

  Fly   311 RKF--------GTKGELTEQ-LANVLKALWTCKNESDHSTSFKAVVDRYGTQFRSSTQHDAQEFL 366
            ..|        ..||.|:.: |.|.|     |:.               ..:|:...|.|:||.|
Human   254 ALFLFLHSMKETEKGPLSPKVLFNQL-----CQK---------------APRFKDFQQQDSQELL 298

  Fly   367 FWLLDKVHEDLNTASKRRYKSLKNSYGRSDEVIAAETLANHIRC------NNSFVQAVFQAQFRS 425
            .:|||.|..:   .:||...|:..::.......|.:.....::.      ..:|:..:|..:..|
Human   299 HYLLDAVRTE---ETKRIQASILKAFNNPTTKTADDETRKKVKAYGKEGVKMNFIDRIFIGELTS 360

  Fly   426 SLTCPRCEKQSNTFDPFHCISVQLPQLTQQTIFVTVVYMTRLPRQVRMGLRVPAGSPIVALRE-- 488
            ::.|..|...|...|||  |.:.||.:.:           |:.:.:..|..    :...:|||
Human   361 TVMCEECANISTVKDPF--IDISLPIIEE-----------RVSKPLLWGRM----NKYRSLRETD 408

  Fly   489 --QLQADTGIEG---SRMVLVDLNAEGFTRVFYDTQPVETLSSIETIYC-----IEVPAATPVAK 543
              :...:..||.   .|......:::..:::.:|.:.:..|||.||:..     :|:...:.:..
Human   409 HDRYSGNVTIENIHQPRAAKKHSSSKDKSQLIHDRKCIRKLSSGETVTYQKNENLEMNGDSLMFA 473

  Fly   544 AATPSETGDKSAPTAVTPSPA----------AAQSQADLLLLVANVYRAKDGADITRFGAPFSMK 598
            :...||:....:||..:...|          :..|:::.......::|:..|:.:...|..:.:.
Human   474 SLMNSESRLNESPTDDSEKEASHSESNVDADSEPSESESASKQTGLFRSSSGSGVQPDGPLYPLS 538

  Fly   599 APRDCSYQDLQKRMLREMAPLLKPEVFSYATPLAE-MFRIRLQDP-SADPDTYLEQVEHPLLTEM 661
            |.:                .|...|..|....:|| :..:||... :.|.|  .::...||   .
Human   539 AGK----------------LLYTKETDSGDKEMAEAISELRLSSTVTGDQD--FDRENQPL---N 582

  Fly   662 IDMALSVLSSEAGPQHIKLLLEWSSPEAHFISKQQDTEEAVVEHESVARLSASKPSDTAALTLEQ 726
            |...|..|..    :|::..    ||:..|                 ..||.|..:.:...:::.
Human   583 ISNNLCFLEG----KHLRSY----SPQNAF-----------------QTLSQSYITTSKECSIQS 622

  Fly   727 CLEHYTKAETLSAEDAWRCPHCQQ-------------------YLPVVKTLGLWSLPDILVVHFK 772
            ||..:|..|.|...:...|.:|.:                   |....|.|.:.::|.:|::|.|
Human   623 CLYQFTSMELLMGNNKLLCENCTKNKQKYQEETSFAEKKVEGVYTNARKQLLISAVPAVLILHLK 687

  Fly   773 RFRQHQSKGPQAAKLTTMVKFPLTAFDMSPHLARGVHESASSSLGMGTGIGLGLGLGSNPWKKAR 837
            ||  ||: |....|:...|.||| ..|::|..
Human   688 RF--HQA-GLSLRKVNRHVDFPL-MLDLAPFC--------------------------------- 715

  Fly   838 SVDSRSSTLNSRCDAKDTRYDLYAVCYHQGDTLETGHYTA------------------------- 877
                 |:|..:........|.||.:..|.| ::..|||||
Human   716 -----SATCKNASVGDKVLYGLYGIVEHSG-SMREGHYTAYVKVRTPSRKLSEHNTKKKNVPGLK 774

  Fly   878 ACKNPYDRQWYKFDDQRVSKVPEDDIEQDIINNEAYMLFYQR 919
            |..|....||....|..:..||    |...::.:||:|||:|
Human   775 AADNESAGQWVHVSDTYLQVVP----ESRALSAQAYLLFYER 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	38/145 (26%)
		Peptidase_C19	266..>461	CDD:271592	53/227 (23%)
		Peptidase_C19R	<713..918	CDD:239139	51/248 (21%)
USP45	NP_001073950.1	Interaction with ERCC1. /evidence=ECO:0000269\|PubMed:25538220	1..62
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		zf-UBP	62..132	CDD:280334
		Peptidase_C19	191..>387	CDD:271592	53/220 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..443		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	479..533		7/53 (13%)
		Peptidase_C19K	<603..811	CDD:239132	54/271 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900