DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp15-31 and UBP9

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_192795.3	Gene:	UBP9 / 826649	AraportID:	AT4G10570	Length:	923	Species:	Arabidopsis thaliana

Alignment Length:	840	Identity:	229/840 - (27%)
Similarity:	343/840 - (40%)	Gaps:	227/840 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 KRTRALRRSSFRKFLNRIAQHL------------SSTVNVVSEEKHSPANRIAFIEIVPFYTGCW 215
            ||...|......|.|...:.|:            ||:.:.:|    |..|.:|.:.:.|
plant   199 KRKNGLLDPLSYKSLEESSLHMDQDILVEVDGLSSSSQSAMS----STGNELALVPLEP------ 253

  Fly   216 RRKEANKHGQPSVSG---------------SSSGGGGGAGGPGGGERVPPIGGYQWPADQTPGVM 265
            .|......|.|::|.               |...|.......|.||:              .|:.
plant   254 SRSIVTIAGGPTLSNGHSTTSNFSLFPRITSEDDGRDSLSILGKGEK--------------GGLA 304

  Fly   266 GLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLKRRNKINSRKFGTKGELTEQLANVLKAL 330
            ||.|.|||||||:.||||:||..:.|||:.| |..|:.|.|.:     |..|||.....::||.|
plant   305 GLSNLGNTCFMNSALQCLAHTPPIVEYFLQD-YSDDINRDNPL-----GMCGELAIAFGDLLKKL 363

  Fly   331 WTCKNESDHSTSFKAVVDRYGTQFRSSTQHDAQEFLFWLLDKVHEDLNTASKRRYKSLKNSYGRS 395
            |:....:....:||..:.|:..||....|||:||.|.:|||.:|||||...::.|..||:|..|.
plant   364 WSSGRNAVAPRAFKTKLARFAPQFSGYNQHDSQELLAFLLDGLHEDLNKVKRKPYIELKDSDSRP 428

  Fly   396 DEVIAAETLANHIRCNNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCISVQLPQLTQQTIFVT 460
            |:.:|.|....|...|:|.:..|.|.|::|:|.||.|.|.|.|||||..:||.||....:::.:|
plant   429 DDEVAEELWNYHKARNDSVIVDVCQGQYKSTLVCPVCGKISITFDPFMYLSVPLPSTLTRSMTIT 493

  Fly   461 VVYMTRLPRQVRMGLRVPAGSPIV-----ALREQLQADTGIEGSRMVLVD----LNAEGFT-RVF 515
            |.|..        |.|:|....::     ::|:.:.|    .|:...|.:    |.||.:. ::|
plant   494 VFYCD--------GSRLPMPYTVIVPKQGSIRDLITA----LGTACCLAEDESLLLAEVYDHKIF 546

  Fly   516 -YDTQPVETLSSIETIYCIEVPAATPVAKAATPSETGDKSAPTAVTPSPAAAQSQADLLLLVANV 579
             |...|:::||:|:....|       ||........|.:.|...:.   ...|.:|        |
plant   547 RYFEIPLDSLSAIKDDEHI-------VAYRLNQIPKGSRKAKLEIL---HGGQERA--------V 593

  Fly   580 YRAKDGADITRFGAPFSMKAPRDCSYQDLQKRMLREMAPL----LKPEVFSYATPLAEMF---RI 637
            ..:..|:|:..||.||       .:|.:.:        ||    :...:..:.:||.::.   :|
plant   594 LDSVRGSDVKLFGTPF-------VTYVNTE--------PLSGTDIDAVISGFLSPLHKVHAPSKI 643

  Fly   638 -------RLQDPSAD--------PDTYLEQVE------HPLLTEMIDMALSVLSSEA--GPQHI- 678
                   .|.|.:.|        |||.::...      ...||:...:.:..|.||:  .|..:
plant   644 HNGSDNGHLADATVDQASGILSSPDTEIDNASDRELSFRIFLTDERGLNIKPLQSESSISPGTVT 708

  Fly   679 KLLLEWSS--------------PEAHFISKQQDTEEAVVEHESVARLSASKPSDTAALTLEQCLE 729
            ::|:||:.              ||.|..|                  .::|.:...:::|..|||
plant   709 RVLVEWNEGEHERYDSSYLSDLPEVHKTS------------------FSAKKTRQESISLFSCLE 755

  Fly   730 HYTKAETLSAEDAWRCPHCQQYLPVVKTLGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFP 794
            .:...|.|..:|.|.||.|:::....|.|.||.||||||.|.|||...:.   ...|:.|.|.||
plant   756 AFLAEEPLGPDDMWFCPSCKEHRQANKKLDLWKLPDILVFHLKRFTYSRY---LKNKIDTFVNFP 817

  Fly   795 LTAFDMSPHLARGVHESASSSLGMGTGIGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTRYDL 859
            :...|:|.::.   :::..|.|                                        |:|
plant   818 VHDLDLSKYVK---NKNGQSYL----------------------------------------YEL 839

  Fly   860 YAVCYHQGDTLETGHYTAACKNPYDRQWYKFDDQRVSKVPEDDIEQDIINNEAYMLFYQR 919
            |||..|.|. |..|||||..|...|.:||.|||..||.|.|.:|.    |:.||:|||:|
plant   840 YAVSNHYGG-LGGGHYTAYAKLIDDNKWYHFDDSHVSSVNESEIR----NSAAYVLFYRR 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	52/120 (43%)
		Peptidase_C19	266..>461	CDD:271592	81/194 (42%)
		Peptidase_C19R	<713..918	CDD:239139	65/204 (32%)
UBP9	NP_192795.3	UBP12	17..894	CDD:227847	228/838 (27%)
		DUSP	38..137	CDD:197831
		Peptidase_C19	304..>480	CDD:271592	77/181 (43%)
		USP7_C2	505..>566	CDD:291217	14/71 (20%)
		Peptidase_C19R	<740..893	CDD:239139	65/203 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	1	1.000	-	-		FOG0000596
OrthoInspector	1	1.000	-	-		otm3497
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21646
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920