Protein Alignment Usp15-31 and USP9X

DIOPT Version :10

• Sequence 1: NP_611959.2
• Gene: Usp15-31 / 37954
• FlyBaseID: FBgn0050421
• Length: 1272
• Species: Drosophila melanogaster
• Sequence 2: NP_001397677.1
• Gene: USP9X / 8239
• HGNCID: 12632
• Length: 2575
• Species: Homo sapiens
• Alignment Length: 1124
• Identity: 210/1124 - (18%)
• Similarity: 347/1124 - (30%)
• Gaps: 408/1124 - (36%)

  Fly   108 SHTAISSCVGGG----------------RGRS---GSIVSLSSYEAPFISSTNNNTTTASNGNNN 153
            :||.|...|||.                :.:|   ..:..:|| ..|....::::::|.|.||:.
Human   933 AHTKIELFVGGELIDPADDRKLIGQLNLKDKSLITAKLTQISS-NMPSSPDSSSDSSTGSPGNHG 996

  Fly   154 NSSSSNINSKRTRAL------RRSSFRKFLNRIAQHLSSTVNVVSEEKHSPAN---RIAFIEIVP 209
            |..|...|.:....|      ....:..||.::|. |.|::|:      .|..   |:....:.|
Human   997 NHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVAD-LGSSLNM------PPLRDGARVLMKLMPP 1054

  Fly   210 FYTGCWRRK----EANKHGQPSVSGSSSGGGGGAGG---------------PGGGERVPPIGGYQ 255
            ..|...:.:    :..|.|:.|:|.|......|...               |.|.........:|
Human  1055 DSTTIEKLRAICLDHAKLGESSLSPSLDSLFFGPSASQVLYLTEVVYALLMPAGAPLADDSSDFQ 1119

  Fly   256 WPADQTPGVMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLKRRN--KINSRKF----- 313
            :..        ||:.|    :..||..|:..:.|.        .||::.|.  .:|:.|.
Human  1120 FHF--------LKSGG----LPLVLSMLTRNNFLP--------NADMETRRGAYLNALKIAKLLL 1164

  Fly   314 -----------------GTKG--------ELTEQLANVLK-ALWTCKNESDHSTSFKAVVDRYGT 352
                             |.:|        ::|...|.||: ||.:..|.|.     :.::.....
Human  1165 TAIGYGHVRAVAEACQPGVEGVNPMTQINQVTHDQAVVLQSALQSIPNPSS-----ECMLRNVSV 1224

  Fly   353 QFRSSTQHDAQEF------------LFWL---------------LDKVHEDLNTASKRRYKSLKN 390
            :.......:|..:            :.|.               :.|::|..|..         |
Human  1225 RLAQQISDEASRYMPDICVIRAIQKIIWASGCGSLQLVFSPNEEITKIYEKTNAG---------N 1280

  Fly   391 SYGRSDEVIAAETLANH----------------------------IRCNNSFVQAVFQAQFRSSL 427
            .....||.:..|.|...                            :.|::..|:.|.|.||  .|
Human  1281 EPDLEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHSKTVRQVAQEQF--FL 1343

  Fly   428 TCPRCEKQSNTFDPFHCISVQLPQLTQQTIFVTVVYMTRLPRQVRMG-----------------L 475
            .|.||           |:. ..|.|...|:..||:..|...|....|                 :
Human  1344 MCTRC-----------CMG-HRPLLFFITLLFTVLGSTARERAKHSGDYFTLLRHLLNYAYNSNI 1396

  Fly   476 RVPAGSPIV--------ALREQLQ--ADTGIEGSRMVLVDLNAEGFTRVFYDTQPVETLSSIETI 530
            .||....::        .:|:.::  .:||||.:.:       ||...|..:....:|......|
Human  1397 NVPNAEVLLNNEIDWLKRIRDDVKRTGETGIEETIL-------EGHLGVTKELLAFQTSEKKFHI 1454

  Fly   531 YCIE--------------VPAATPVAKAATPSE-TGDKSAPTAVTPSPAAAQSQADLLLLVA--- 577
            .|.:              .||:....:.....| ..:::.|  |..||....:..:||:.:|
Human  1455 GCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQAIP--VCGSPPTINAGFELLVALAVGC 1517

  Fly   578 --NVYRAKD--------GADITRFGA--------PFSMKAPR----------DCSYQDLQKRMLR 614
              |:.:..|        |..||...|        |...:.|:          .|....:.:::.
Human  1518 VRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLY- 1581

  Fly   615 EMAPLLKPEVFSYATPLA----EMFRIRLQ------DPSADPDTYLEQVE-HPLLTEMIDMA--- 665
             |.|.::..:.:.....:    :|.....|      ||..|...|.:|.| .|.|::..|..
Human  1582 -MIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDDVFGYPQQFEDKPALSKTEDRKEYN 1645

  Fly   666 LSVLSSEAGPQHIKLLLE---------------------WSSP----EAH-----FISKQQDTEE 700
            :.||      :|::::..                     |..|    |.|     |.|.....:|
Human  1646 IGVL------RHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDE 1704

  Fly   701 AVVEHESVARLSASKPSDTAALTLEQ-------C--------------------LEHYTKAETLS 738
            |:......|.||.......|...:.|       |                    ||.|.|.:.|.
Human  1705 ALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLE 1769

  Fly   739 AEDAWRCPHCQQYLPVVKTLGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFDMSPH 803
            ..:|:.|..|.:.:..||.|.:..||.:|.:..||| .:..:...|.|.....:|| ...||.|:
Human  1770 GANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRF-DYDWERECAIKFNDYFEFP-RELDMEPY 1832

  Fly   804 LARGVHESASSSLGMGTGIGLGLGLGSNPWKK--ARSVDSRSSTLNSRCDAKDTRYDLYAVCYHQ 866
            ...||.:....::              ||..:  .:|..|.|.|..|      |:|.|..|..|.
Human  1833 TVAGVAKLEGDNV--------------NPESQLIQQSEQSESETAGS------TKYRLVGVLVHS 1877

  Fly   867 GDTLETGHYTAAC--KNPYD---RQWYKFDDQRVSKVPEDDIEQ------------DIINN---- 910
            |.. ..|||.:..  :|..|   .:||||||..|::...||.|:            ::.::
Human  1878 GQA-SGGHYYSYIIQRNGGDGERNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKR 1941

  Fly   911 ----------EAYMLFYQR 919
                      .||:|||:|
Human  1942 MSYRRQKRWWNAYILFYER 1960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	UBP12	<255..921	CDD:227847	174/930 (19%)
USP9X	NP_001397677.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..65
		Ubl1_cv_Nsp3_N-like	<905..969	CDD:475130	7/35 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	972..1004		9/32 (28%)
		peptidase_C19C	1560..1963	CDD:239124	91/432 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1597..1626		5/28 (18%)
		DUF3517	2102..2481	CDD:463438