DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp15-31 and Usp45

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_690038.1	Gene:	Usp45 / 77593	MGIID:	101850	Length:	813	Species:	Mus musculus

Alignment Length:	947	Identity:	188/947 - (19%)
Similarity:	302/947 - (31%)	Gaps:	353/947 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 GKN----NGARERRGSHTAISSCVGGGRGRSGSIVSLSS-----YEAPFISSTNNNTTTASNGNN 152
            |||    :..|..:.|.|. |.||         ::|||:     ||.
Mouse    94 GKNSESQHSLRHFKSSGTE-SHCV---------VISLSTWVIWCYEC------------------ 130

  Fly   153 NNSSSSNINSKRTRALRRSSFRKFLNRIAQHLSSTVNVVSEEKHSPANRI-AFIEIVPFYTGCWR 216
            |...|::.|            :|.|.:|...|         :||:...:. ||..|:..   |..
Mouse   131 NEKLSTHCN------------KKVLAQIVDFL---------QKHAFKTQTGAFSRIIKL---CEE 171

  Fly   217 RKEANKHGQPSVSGSSSGGGGGAGGPGGGERVPPIGGYQWPADQTPGVMGLKNHGNTCFMNAVLQ 281
            ::||         |....|..|.                    ..|.|.|:.|.|||||.|||:|
Mouse   172 KREA---------GEIKKGKKGC--------------------TVPSVKGITNLGNTCFFNAVIQ 207

  Fly   282 CLSHTDILAEYFVLDQYKAD-LKRRNKINSR--------KFGTKGELTEQLANVLKALWTCKNES 337
            .|:.|.||.|  ::::.|.| .|.:..::|.        :..:.|.||..|...|.::   |...
Mouse   208 NLAQTYILFE--LMNEIKEDGTKFKISLSSAPQLEPLVVELSSPGPLTSALFLFLHSM---KEAE 267

  Fly   338 DHSTSFKAVVDRY---GTQFRSSTQHDAQEFLFWLLDKVHEDLNTASKRRYKSLKNSYGRSDEVI 399
            ....|.|.:.::.   ..:|:...|.|:||.|..|||.|..:   .:||...|:..::.......
Mouse   268 KGPLSPKVLFNQLCQKAPRFKGFQQQDSQELLHHLLDAVRTE---ETKRIQASILKAFNNPTTKT 329

  Fly   400 AAETLANHIRC------NNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCISVQLPQLTQQTIF 458
            |.:.....::.      ..:|:..:|..:..|::.|..|...|...|||  |.:.||.:.:
Mouse   330 ADDETRKKVKAYGKEGVKMNFIDRIFIGELTSTVMCEECANISTMKDPF--IDISLPIIEE---- 388

  Fly   459 VTVVYMTRLPRQVRMGLRVPA------------GSPIVALREQLQADTGIEGSRMVLVDLNAEGF 511
                   |:.:.|.:|.....            |:..|....|.:|........    |.|....
Mouse   389 -------RVSKPVLLGKMSKCRSLQETDQDHNKGTVTVGNAHQPRASRKHSSPN----DKNQLSH 442

  Fly   512 TRVFYDTQPVETLSSIETIYCIEVPAATPVAKAATPSETGDKSAPTAVTPSPAAAQSQADLLLLV 576
            .|......|.|...::.|                .|.....:::|.|.|.|..|:.:::
Mouse   443 DRKHLRKWPSEEEKTVVT----------------HPKNDNLEASPPASTLSTEASLNES------ 485

  Fly   577 ANVYRAKDGADITRFGAPFSMKAPRDCSYQDLQKRMLREMAPLLKPEVFSYATPLAEMFRIRLQD 641
                 ..||::             ||.|.:.    .:...:...:||:   |:....:.|.|
Mouse   486 -----LTDGSE-------------RDASLES----SVDADSEASEPEI---ASKQPVLLRSR--- 522

  Fly   642 PSADPDTYLEQVEH-PLLTEMIDMALSVLSSEAGPQHIKLLLEWSSPEAHFISKQQDTEEAVVE- 704
              .|...:.||..| ||.:|:             ||         :.|.|  ..:::..||:.|
Mouse   523 --GDSCGHAEQHPHLPLASEL-------------PQ---------AKETH--GGEEEMAEAIAEL 561

  Fly   705 --------------------------------------HESVARLSASKPSDTAALTLEQCLEHY 731
                                                  ..:...||.|..:.:...:::.||..:
Mouse   562 HLSGTVTGNRDFHREKQPLNVPNNLCFSEGKHTRLHSAQNAFQTLSQSYVTTSKECSVQSCLYQF 626

  Fly   732 TKAETLSAEDAWRCPHCQQ-------------------YLPVVKTLGLWSLPDILVVHFKRFRQH 777
            |..|.|...:...|..|.:                   |....|.|.:.::|.||::|.|||  |
Mouse   627 TSMELLMGNNKLLCEDCTEKRRKCHKETSSAEKKAGGVYTNARKQLLISAVPAILILHLKRF--H 689

  Fly   778 QSKGPQAAKLTTMVKFPLTAFDMSPHLARGVHESASSSLGMGTGIGLGLGLGSNPWKKARSVDSR 842
            |: |....|:...|.|||| .|::|..|     :...::.:|
Mouse   690 QA-GLSLRKVNRHVDFPLT-LDLAPFCA-----ATCKNISVG----------------------- 724

  Fly   843 SSTLNSRCDAKDTRYDLYAVCYHQGDTLETGHYT----------------------AACKNP--- 882
                      :...|.||.:..|.| ::..||||                      |..|.|
Mouse   725 ----------EKVLYGLYGIVEHSG-SMRGGHYTAYVKVRVPSRKLSECITGRKTAAGLKEPDGE 778

  Fly   883 YDRQWYKFDDQRVSKVPEDDIEQDIINNEAYMLFYQR 919
            ....|....|..|..||    |...::.:||:|||:|
Mouse   779 LGGHWVHVSDTYVQVVP----ESRALSAQAYLLFYER 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	40/132 (30%)
		Peptidase_C19	266..>461	CDD:271592	54/212 (25%)
		Peptidase_C19R	<713..918	CDD:239139	53/248 (21%)
Usp45	NP_690038.1	Interaction with ERCC1. /evidence=ECO:0000305\|PubMed:25538220	1..62
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		UBP14	<72..>359	CDD:227532	78/353 (22%)
		Peptidase_C19	192..>388	CDD:351799	54/205 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..552		37/226 (16%)
		Peptidase_C19K	<587..810	CDD:239132	55/269 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900