DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp15-31 and Usp16

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_077220.2	Gene:	Usp16 / 74112	MGIID:	1921362	Length:	825	Species:	Mus musculus

Alignment Length:	783	Identity:	171/783 - (21%)
Similarity:	269/783 - (34%)	Gaps:	280/783 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 VMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKAD------------LKRRNKINSRKFGTK 316
            |.||.|.|||||.|||:|.||.|.:|.|  :|.:.|..            |....::|   ....
Mouse   194 VKGLSNLGNTCFFNAVMQNLSQTPVLRE--LLKEVKMSGTIVKIEPPDLALTEPLEVN---LEPP 253

  Fly   317 GELTEQLANVLKALWTCKNESDHSTSFKAVVDRYGTQFRSSTQHDAQEFLFWLLDKVH-EDLNTA 380
            |.||..::..|..:...|..........:.|.:..|:|:...|.|:||.|.:|||.:. |:....
Mouse   254 GPLTLAMSQFLSEMQENKKRVVTPKELFSQVCKKATRFKGYQQQDSQELLRYLLDGMRAEEHQRV 318

  Fly   381 SKRRYKSLKNSYGRSDEVIAAETLANHI------RCNNSFVQAVFQAQFRSSLTCPRCEKQSNTF 439
            ||...|:..||..:.||.:     .|.:      :...|||..:|..:..|::.|..|...|...
Mouse   319 SKGILKAFGNSTEKLDEEV-----KNKVKDYEKKKAIPSFVDRIFGGELTSTIMCDECRTVSLVH 378

  Fly   440 DPFHCISVQLPQLTQQT---------IFVTV-------------VYM---TRLP----------- 468
            :.|  :.:.||.|..|:         :.:|:             .||   :.||
Mouse   379 ESF--LDLSLPVLDDQSGKKSINDKNVKMTMEEEDKDSEEEKDDSYMKSRSDLPSGTSKHLQKKA 441

  Fly   469 ------------RQVRMGLRVPAGSPIVAL----REQLQADTGIEGSRMVLVDLNA-----EGFT 512
                        ||.::..|....:.:.|.    ..:.:|||.:.|.  |.||.::     |..|
Mouse   442 KKQAKKQAKNQRRQQKIQERFLHFNELCATDYTEDNEREADTALAGE--VEVDTDSTHGSQEEAT 504

  Fly   513 RVFYDTQPVETLSSIETIYCIEVPAATPVAKAATPSETGDKSAPT-----AVTPSPAAAQSQADL 572
            ::...... :.|...|::  ||   .||..: .:|.:.|.|||.|     .|||:|
Mouse   505 QIELSVNQ-KDLDGQESM--IE---RTPDVQ-ESPEDLGVKSANTESDLGIVTPAP--------- 553

  Fly   573 LLLVANVYRAKDGADITRFGAPFSMKAPRDCSYQDLQKRMLREMAPL--LKPEVFSYATPLAEMF 635
                                     :.|||.:...|::|...|:..:  ||
Mouse   554 -------------------------ECPRDFNGAFLEERTSGELDIINGLK-------------- 579

  Fly   636 RIRLQDPSADPDTYLEQVEHPLLTEMIDMALSVLSSEAGPQHIKLLLEWSSPEAHFIS----KQQ 696
            .:.| :.:.|||..  .:|.|            ..|.:.|:..:::.|  .||..|.:    :..
Mouse   580 NLNL-NAAVDPDEI--NIEIP------------NDSHSAPKVYEVMNE--DPETAFCTLANREAF 627

  Fly   697 DTEEAVVEHESVARLSASKPSDTAALTLEQCLEHYTKAETLSAEDAWRCPHCQQ----------- 750
            .|:|..::|                     ||..:|:.|.|...:...|..|.:
Mouse   628 STDECSIQH---------------------CLYQFTRNEKLQDANKLLCEVCSRRQCNGPKANIK 671

  Fly   751 ------YLPVVKTLGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFDMSPHLARGVH 809
                  |....|.:.:...|.:|.:|.|||:|   .|....|:...:||| ...|::|...
Mouse   672 GDRRHVYTNAKKQMLVSLAPPVLTLHLKRFQQ---AGFNLRKVNKHIKFP-EILDLAPFCT---- 728

  Fly   810 ESASSSLGMGTGIGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTRYDLYAVCYHQGDTLETGH 874
                                    .|.::|...|:.:         .|.||.|..|.| |:.:||
Mouse   729 ------------------------LKCKNVAEESTRV---------LYSLYGVVEHSG-TMRSGH 759

  Fly   875 YTAACKN----------------PYD-------RQWYKFDDQRVSKVPEDDIEQDIINNEAYMLF 916
            |||..|.                |.|       .||:...|..|..||    ...::|::||:||
Mouse   760 YTAYAKERTASCHLSNLVLHGDIPQDCEMESTKGQWFHISDTHVQAVP----ITKVLNSQAYLLF 820

  Fly   917 YQR 919
            |:|
Mouse   821 YER 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	40/131 (31%)
		Peptidase_C19	266..>461	CDD:271592	59/222 (27%)
		Peptidase_C19R	<713..918	CDD:239139	52/244 (21%)
Usp16	NP_077220.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		zf-UBP	48..122	CDD:366940
		UBP12	<135..823	CDD:227847	170/781 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..184
		Peptidase_C19K	196..>401	CDD:239132	59/216 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..456		6/62 (10%)
		Peptidase_C19K	<624..822	CDD:239132	55/264 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900