Protein Alignment Usp15-31 and USP17L25

DIOPT Version :10

• Sequence 1: NP_611959.2
• Gene: Usp15-31 / 37954
• FlyBaseID: FBgn0050421
• Length: 1272
• Species: Drosophila melanogaster
• Sequence 2: NP_001229255.1
• Gene: USP17L25 / 728373
• HGNCID: 44452
• Length: 530
• Species: Homo sapiens
• Alignment Length: 750
• Identity: 127/750 - (16%)
• Similarity: 196/750 - (26%)
• Gaps: 383/750 - (51%)

  Fly   266 GLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLKRRNKINSRKFGTKG-ELTEQLANVLKA 329
            ||:|.||||::||.||||::|..||.|.:..::.....|.          || .|....|::.:|
Human    81 GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRH----------KGCMLCTMQAHITRA 135

  Fly   330 LWTCKNESDHSTSFKAVVDRYGTQFRSSTQHDAQEFLFWLLDKVHEDLNTASKRRYKSLKNSYGR 394
            |....:....|.:..|       .|....|.||.|||.:.:|.:.:......|:
Human   136 LHNPGHVIQPSQALAA-------GFHRGKQEDAHEFLMFTVDAMKKACLPGHKQ----------- 182

  Fly   395 SDEVIAAETLANHIRCNNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCISVQLPQLTQQTIFV 459
                      .:|...:.:.:..:|...:||.:.|..|...|:||||:
Human   183 ----------VDHHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPY----------------- 220

  Fly   460 TVVYMTRLPRQVRMGLRVPAGSPIVALREQLQADTGIEGSRMVLVDLNAEGFTRVFYDTQPVETL 524
                                                                             
Human   221 ----------------------------------------------------------------- 220

  Fly   525 SSIETIYCIEVPAATPVAKAATPSETGDKSAPTAVTPSPAAAQSQADLLLLVANVYRAKDGADIT 589
                                                                             
Human   221 ----------------------------------------------------------------- 220

  Fly   590 RFGAPFSMKAPRDCSYQDLQKRMLREMAPLLKPEVFSYATPLAEMFRIRLQDPSADPDTYLEQVE 654
                                                                             
Human   221 ----------------------------------------------------------------- 220

  Fly   655 HPLLTEMIDMALSVLSSEAGPQHIKLLLEWSSPEAHFISKQQDTEEAVVEHESVARLSASKPSDT 719
                   :|:||.:                                                  .
Human   221 -------LDIALDI--------------------------------------------------Q 228

  Fly   720 AALTLEQCLEHYTKAETLSAEDAWRCPHCQQYLPVVKTLGLWSLPDILVVHFKRFRQHQSKGPQA 784
            ||.:::|.||...|.|.|:.|:|:.|..|.|..|..|||.|.:...:|::..|||......
Human   229 AAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFSDVTGN---- 289

  Fly   785 AKLTTMVKFPLTAFDMSPHLARGVHESASSSLGMGTGIGLGLGLGSNPWKKARSVDSRSSTLNSR 849
             |:...|::| ...||.|::::           ..||
Human   290 -KIAKNVQYP-ECLDMQPYMSQ-----------PNTG---------------------------- 313

  Fly   850 CDAKDTRYDLYAVCYHQGDTLETGHYTAACKNPYDRQWYKFDDQRVSKVPEDDIEQDIINNEAYM 914
                ...|.||||..|.|.:...|||.:..| ..:.||||.||   ::|....| ..:::.:||:
Human   314 ----PLVYVLYAVLVHAGWSCHNGHYFSYVK-AQEGQWYKMDD---AEVTASSI-TSVLSQQAYV 369

  Fly   915 LFYQRRSVDAGECSGSSSNSGDHWVSRIAPASSSSASSTSG--KEREPV----KLEENTESPAAV 973
            |||.::|  ..|....|.:.|..  .|...|..:...:|.|  |...|.    :|:|:....|..
Human   370 LFYIQKS--EWERHSESVSRGRE--PRALGAEDTDRRATQGELKRDHPCLQAPELDEHLVERATQ 430

  Fly   974 EVT--------EKAQSKPVDIVCQDKAKGTADGPD 1000
            |.|        |:.::||...|  .|.:||.. ||
Human   431 ESTLDHWKFLQEQNKTKPEFNV--RKVEGTLP-PD 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	UBP12	<255..921	CDD:227847	103/655 (16%)
USP17L25	NP_001229255.1	Peptidase_C19E	79..373	CDD:239126	102/652 (16%)
		HABP4_PAI-RBP1	<417..454	CDD:461421	9/38 (24%)