DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp15-31 and USP31

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_065769.3	Gene:	USP31 / 57478	HGNCID:	20060	Length:	1352	Species:	Homo sapiens

Alignment Length:	1358	Identity:	399/1358 - (29%)
Similarity:	575/1358 - (42%)	Gaps:	343/1358 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 VTSSAGAENDNESGKNNGARERRGSHTAISSCVGGGRGRSGSIVSLSSYEAPFISSTNNNTTTAS 148
            ||:.........|||...:..:|...:..:.  |||.|..|:    |...||
Human     4 VTAPGSGPPAAASGKEKRSFSKRLFRSGRAG--GGGAGGPGA----SGPAAP------------- 49

  Fly   149 NGNNNNSSSSNINSKRTRALRRSSFRKFLNRIAQHLSSTVNVVSEEKHSPANRIAFIEIVPFYTG 213
                  ||.|:.:|.|       |...|::|:.:.| ||::.:|.|..:|
Human    50 ------SSPSSPSSAR-------SVGSFMSRVLKTL-STLSHLSSEGAAP--------------- 85

  Fly   214 CWRRKEANKHGQPSVSGSSSGG------GGGAGGPGGGERVPPIGGYQWP---ADQTPGVMGLKN 269
                              ..||      .|.|..|......||......|   |:..|||.||:|
Human    86 ------------------DRGGLRSCFPPGPAAAPTPPPCPPPPASPAPPACAAEPVPGVAGLRN 132

  Fly   270 HGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLKRRNKINSRKFGT----KGELTEQLANVLKAL 330
            |||||||||.|||||:|::.|||..|.||:|.....:....:..|.    :||:|||||::::||
Human   133 HGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGEVTEQLAHLVRAL 197

  Fly   331 WTCKNESDHSTSFKAVVDRYGTQFRSSTQHDAQEFLFWLLDKVHEDLNTASKRRYKSLKNSYGRS 395
            ||.:....||..||.:|.:...|:|.::||||||||.||||:||||||.:.|:..:........:
Human   198 WTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHSVKQSGQPPLKPPSET 262

  Fly   396 DEVIAAETLANHIRCNNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCISVQLPQLTQQTIFVT 460
            |.:....:..   .| ::|||.:||||:|||||||.|:|||||||||.|||:.:|....:.::||
Human   263 DMMPEGPSFP---VC-STFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPLPHTRPLYVT 323

  Fly   461 VVYMTRLPRQVRMGLRVPAGSPIVALREQLQADTGIEGSRMVLVDLNAEGFTRVFYDTQPVETLS 525
            |||..:....:|:|:.||....:..|||.:..:|.|...::||.::..:||.|.|.||..:||:.
Human   324 VVYQGKCSHCMRIGVAVPLSGTVARLREAVSMETKIPTDQIVLTEMYYDGFHRSFCDTDDLETVH 388

  Fly   526 SIETIYCIEVPA------------------------ATPVAKAATPSETGDKSAPTAVTPSPAAA 566
            ..:.|:..|.|.                        .....:.::|::|..|...   ..||.:.
Human   389 ESDCIFAFETPEIFRPEGILSQRGIHLNNNLNHLKFGLDYHRLSSPTQTAAKQGK---MDSPTSR 450

  Fly   567 QSQADLLLLVANVYRAKDGADITRFGAPFSMKAPRDCSYQDLQKRMLREMAPLLKPEVFSYATPL 631
            .....::|||.|  ||..|....|||.||.:...:..::..|||.:|.:|...|:|.|.....|
Human   451 AGSDKIVLLVCN--RACTGQQGKRFGLPFVLHLEKTIAWDLLQKEILEKMKYFLRPTVCIQVCP- 512

  Fly   632 AEMFRIRLQDPSADPDTY-LEQVEHPLLTEMIDMALSVLSSEAGPQHIKLLLEWSSPEAHFISKQ 695
               |.:|:  .|....|| |.|.|.||...:::.||. .....|..|:||::||......|:...
Human   513 ---FSLRV--VSVVGITYLLPQEEQPLCHPIVERALK-SCGPGGTAHVKLVVEWDKETRDFLFVN 571

  Fly   696 QDTEEAVVEHESVARLSASKPSDTAALTLEQCLEHYTKAETLSAEDAWRCPHCQQYLPVVKTLGL 760
            .: :|.:.:.||| ||...:.......||.||.:.|||.|.|:.:||||||||:|......||.|
Human   572 TE-DEYIPDAESV-RLQRERHHQPQTCTLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSL 634

  Fly   761 WSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFDMSPHLARGVHESASSSLGMGTGIGLG 825
            |:|||:|::|.|||||   :|.:..||..|||||||..||:||:.:....|.|
Human   635 WTLPDVLIIHLKRFRQ---EGDRRMKLQNMVKFPLTGLDMTPHVVKRSQSSWS------------ 684

  Fly   826 LGLGSNPWKKARSVDSRSSTLNSRCDAKDTRYDLYAVCYHQGDTLETGHYTAACKNPYDRQWYKF 890
            |....:||::...:..         |.:|..|||||||.|.| |::.|||||.|||..|..||.|
Human   685 LPSHWSPWRRPYGLGR---------DPEDYIYDLYAVCNHHG-TMQGGHYTAYCKNSVDGLWYCF 739

  Fly   891 DDQRVSKVPEDDIEQDIINNEAYMLFYQRR------SVDAGECSGSSSNSGDHWVSRI---APAS 946
            ||..|.::.||    ::....||:||||||      |.::.....:||:..:|||||:   .|||
Human   740 DDSDVQQLSED----EVCTQTAYILFYQRRTAIPSWSANSSVAGSTSSSLCEHWVSRLPGSKPAS 800

  Fly   947 SSSASST--------------SGKERE---------------------------PVKLEENTESP 970
            .:||:|:              :|:..|                           |:.:.||...|
Human   801 VTSAASSRRTSLASLSESVEMTGERSEDDGGFSTRPFVRSVQRQSLSSRSSVTSPLAVNENCMRP 865

  Fly   971 ----------------------------AAVEVTEKAQSKPVDIVC------------------- 988
                                        :.:|...:|....|.|.|
Human   866 SWSLSAKLQMRSNSPSRFSGDSPIHSSASTLEKIGEAADDKVSISCFGSLRNLSSSYQEPSDSHS 930

  Fly   989 --QDKAKGTA-----DGPDADQEQT------------------------TVPHDLQIEELAFADA 1022
              :.||.|.|     :|...|:..|                        :.|.| ...::|:.|.
Human   931 RREHKAVGRAPLAVMEGVFKDESDTRRLNSSVVDTQSKHSAQGDRLPPLSGPFD-NNNQIAYVDQ 994

  Fly  1023 --DVDTSLGETIKAEV---NLAAK--------------DEPKKVEVEEATPIFAMDEDGSEARQE 1068
              .||:|..:.:||..   :||.|              .||:| .:.:..|..|..|....:...
Human   995 SDSVDSSPVKEVKAPSHPGSLAKKPESTTKRSPSSKGTSEPEK-SLRKGRPALASQESSLSSTSP 1058

  Fly  1069 KKEECVKKEDELSEAPDVSELTAESKTNGHVSSSS---------SSSSSESSLSSRSSPRSLSTS 1124
            .....||    :|..|..|...|:|.:.|....||         ||..|:.|:||.|..:..|.|
Human  1059 SSPLPVK----VSLKPSRSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSAS 1119

  Fly  1125 V---TAASTLQSKFNGHMSAAPALFNGNGNTSQLSSSLQLSRHVLHNHQWHGS-RSSVSAVENAT 1185
            .   ||:||...|.:|..:.:| ...|...||..|.|.:.||..|      || |:|.::.....
Human  1120 ALTYTASSTSAKKASGPATRSP-FPPGKSRTSDHSLSREGSRQSL------GSDRASATSTSKPN 1177

  Fly  1186 QHQQQQAAA-------------SLSLRHSFSTSSNYTETLSSLLRKSANTCSKDTLLF 1230
            ..:..||.|             |::...|.|||      :.|.|::.:.:..|....|
Human  1178 SPRVSQARAGEGRGAGKHVRSSSMASLRSPSTS------IKSGLKRDSKSEDKGLSFF 1229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	65/124 (52%)
		Peptidase_C19	266..>461	CDD:271592	94/198 (47%)
		Peptidase_C19R	<713..918	CDD:239139	84/204 (41%)
USP31	NP_065769.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62		20/89 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..119		11/72 (15%)
		Peptidase_C19	<126..>249	CDD:271592	64/122 (52%)
		Peptidase_C19	129..>335	CDD:271592	98/209 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..185		2/22 (9%)
		Peptidase_C19R	<596..763	CDD:239139	84/195 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	812..835		2/22 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	919..939		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	951..1352		70/298 (23%)
		MIP-T3	1013..>1346	CDD:287245	59/235 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	416	1.000	Domainoid score	I658
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	446	1.000	Inparanoid score	I1640
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40740
orthoMCL	1	0.900	-	-		OOG6_105957
Panther	1	1.100	-	-	O	PTHR21646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5787
SonicParanoid	1	1.000	-	-		X2490
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.860