DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp15-31 and usp43a

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	XP_009300631.1	Gene:	usp43a / 563983	ZFINID:	ZDB-GENE-100211-1	Length:	1154	Species:	Danio rerio

Alignment Length:	1223	Identity:	358/1223 - (29%)
Similarity:	559/1223 - (45%)	Gaps:	200/1223 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 ISSTNNNTTTASNGNNNNSSSSNINSKRTRALRRSSFRKFLNRIAQHLSSTVNV--------VSE 193
            :..|...|..|.:....|.:..:....|.::|:  |...|::||.:.|.:..::        .:|
Zfish     4 LRETRKQTIKAKSAKRKNKTHKSQKLFRRKSLK--SLGNFMSRIVKTLGTLAHLGDADQPDAAAE 66

  Fly   194 EKHSPANRIAFIEIVPFYTGCWRRKEANKHGQPSVSGSSSGGGGGAGGPGGGERVPPIGGYQW-P 257
            :........|.:.    .:|.:|...|.|        |||.|       ...||:      .| .
Zfish    67 DDDGGFGDTASVH----NSGNYRESSARK--------SSSYG-------SVKERL------SWCY 106

  Fly   258 ADQTPGVMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLKRRNKINS--RKFGTKGELT 320
            .::||||.||||||||||||||:||||:|::||||..|:|||.:|..| :||.  :....:||:|
Zfish   107 GEKTPGVQGLKNHGNTCFMNAVVQCLSNTELLAEYLGLEQYKYELNER-RINGMMKSEEVRGEVT 170

  Fly   321 EQLANVLKALWTCKNESDHSTSFKAVVDRYGTQFRSSTQHDAQEFLFWLLDKVHEDLNTAS---- 381
            ::||::::||||.......|..||:||.:||:||:.:.||||.|||.||||.||||.|.::
Zfish   171 DKLASLVRALWTNDYTPQLSVDFKSVVAKYGSQFKGNAQHDALEFLLWLLDCVHEDANLSTNNNQ 235

  Fly   382 KRRYKSLKNSYGRSDEVIAAETLANHIRCNNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCIS 446
            .|...|.|.|.|..:........:......:||||..||||:|||||||.|.|||||||||.|||
Zfish   236 SRNSSSSKGSVGLEESSCPGPANSQQPGTRHSFVQEHFQAQYRSSLTCPHCLKQSNTFDPFLCIS 300

  Fly   447 VQLPQLTQQTIFVTVVYMTRLPRQVRMGLRVPAGSPIVALREQLQADTGIEGSRMVLVDLNAEGF 511
            :.:|....:.:.||:|:.|...|.:|:||.||....|..||..:..:..:...:::|.::|:.||
Zfish   301 LPIPLRQTRALNVTLVFSTEGQRFLRIGLAVPLFGSISTLRAMVAEEGKLSPDQVILTEMNSGGF 365

  Fly   512 TRVFYDTQPVETLSSIETIYCIEVPA---------------ATPVAKAATPSETGDKSAPTAVTP 561
            .|.|.|...:.::|..:.||..:||.               :.| :...|....|.:..|:....
Zfish   366 QRSFSDEDDMTSISESDVIYAFQVPPHFTRGGSMRFSGYHHSLP-SSPYTADFKGHRLPPSGTLS 429

  Fly   562 SPAAAQ-SQADLLLLVANVYRAKDGADITRFGAPFSMKAPRDCSYQDLQKRMLREMAPLLKPEVF 625
            :..... ..:.:|||:.||  |..|...||||.||.|:..|..|:..||:.:..::....|..:.
Zfish   430 TEFLNHGGSSKVLLLICNV--AGSGQQATRFGPPFLMRVERTLSWDHLQQSVCNKLYVFQKTAII 492

  Fly   626 SYATPLAEMFRIRLQDPSADPDTYLEQVEHPLLTEMIDMALSVLSSEAGPQHIKLLLEWSS--PE 688
            .    ..|:|::|:...||...........||....:|.||. |....||.|:||::||.:  .|
Zfish   493 K----TTELFKVRVVGGSASCSYLSPHDSRPLCHPTVDRALK-LCGPGGPLHVKLIIEWDNKIKE 552

  Fly   689 AHFISKQQDTEEAVVEHESVARLSASKPSDTAALTLEQCLEHYTKAETLSAEDAWRCPHCQQYLP 753
            ..|.:.|   ||.:.:.||| |:.........:.||:.|.:.|||.|.|:.:|||:||||:|...
Zfish   553 CLFGNIQ---EEVIEDAESV-RIQQQNHVQQHSCTLDDCFQLYTKEEQLAPDDAWKCPHCKQMQQ 613

  Fly   754 VVKTLGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFDMSPHLARGVHESASSSLGM 818
            .:..:.||:|||||::|.|||||   .|.:..||:|:::||::|.||:||:.:     .|.|:
Zfish   614 GMVKMSLWTLPDILILHLKRFRQ---VGKRRNKLSTLIRFPVSALDMTPHVVK-----RSQSM-- 668

  Fly   819 GTGIGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTRYDLYAVCYHQGDTLETGHYTAACKNPY 883
                 ..|....:.||...:               |..|||||||.|.|. :..|||||.|:|..
Zfish   669 -----KNLAPLPSTWKHGET---------------DFLYDLYAVCNHHGG-MHGGHYTAYCRNSV 712

  Fly   884 DRQWYKFDDQRVSKVPEDDIEQDIINNEAYMLFYQRRSV------DAGECSGSSSNSGDHWV--- 939
            |..||.:||..|..||    |:::....||:||||||:|      ::.....:||:..|||:
Zfish   713 DGHWYSYDDSSVEIVP----EEELCTRGAYILFYQRRNVIPPWSANSSVRGSTSSSMSDHWLIRL 773

  Fly   940 -------SRIAPASSSSASSTSGKEREPV-KLEENTESPAAVEVTEK------AQSKPVDIVCQD 990
                   |.::.:|::..||.:.....|| |.|.:.|...::...|.      .|.:.|.:....
Zfish   774 NGDSKRGSMVSRSSTTCPSSIADSPESPVFKNEPSIEERVSLGGFESRPFVRGIQGRSVSMRSPT 838

  Fly   991 KAK--------GTADG----PDADQEQTTVPHDLQ-----------IEELAFADADVDTSLGETI 1032
            |:|        |..|.    |.::|....:...|:           |..|....:|.|....:|.
Zfish   839 KSKVLPLRWSFGNKDRHKPVPASEQSPAELVEYLESGRRPRCTKDPIVSLMTRPSDKDNDAKKTA 903

  Fly  1033 KAEVNLAAKDEPKKVEV----EEATPIFAMDEDGSEARQEKKEECVKKEDELSEAPDVSELTAES 1093
            |:..:...: .|:.:::    |.::...||.:..:.:.:.::|..:.:.......||.|. :.:|
Zfish   904 KSSSHSGLR-PPEYLKIPQGQERSSSEKAMGQQPASSSRSREEGTLTRRSSRKSKPDQSH-SRKS 966

  Fly  1094 KTNGHVSSSSSSSSSESSLSSRSSPRSLSTS----------------------VTAASTLQSKFN 1136
            ...|..||.|:.|..|::....||.:...:.                      :...|..:|:.|
Zfish   967 SGAGIQSSCSTPSGWETAQKHESSDKRDQSEDKHKKGQETKRHDVFAFLKGGFIKKDSLRKSRDN 1031

  Fly  1137 GHMSAAP---------ALFNGNGNTS---QLSSSLQLSRHVLHNHQWHGSRSSVSAVENATQHQQ 1189
            ..:..|.         :|.||..|.:   ::|:....|||.........||.| |.::.:.....
Zfish  1032 DSVKKADSGVKSPSGVSLSNGTHNKNPEGKVSTMNHGSRHGSELANGKVSRGS-SDIKRSQSSSN 1095

  Fly  1190 QQAAASLSLRHSFSTSSNYTETLSSLLRKSANTCSKDTLLFIDQQSHHHTAGL 1242
            .|:...|.||.:.|...|.| :::.....:.:..|:.||    |::.:.|..|
Zfish  1096 IQSKTDLGLRRTASLHRNGT-SVAQPQSVTGDRGSQSTL----QRTRYSTNSL 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	68/126 (54%)
		Peptidase_C19	266..>461	CDD:271592	100/200 (50%)
		Peptidase_C19R	<713..918	CDD:239139	75/204 (37%)
usp43a	XP_009300631.1	UBP12	<76..746	CDD:227847	268/742 (36%)
		Peptidase_C19	115..>315	CDD:271592	100/200 (50%)
		Peptidase_C19	115..>221	CDD:271592	58/106 (55%)
		Peptidase_C19R	<578..743	CDD:239139	75/199 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	440	1.000	Inparanoid score	I1636
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25166
orthoMCL	1	0.900	-	-		OOG6_105957
Panther	1	1.100	-	-	LDO	PTHR21646
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2490
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.970