DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp15-31 and usp33

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_001016228.1	Gene:	usp33 / 548982	XenbaseID:	XB-GENE-1016674	Length:	892	Species:	Xenopus tropicalis

Alignment Length:	927	Identity:	192/927 - (20%)
Similarity:	318/927 - (34%)	Gaps:	296/927 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 QTPGVMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLKRRNKINSRKFGTKGELTEQLA 324
            :|.|:.||||.||||:|||.||.||:...|..|| ||  ...|.|.:|        |..|.:...
Frog   143 KTRGLTGLKNIGNTCYMNAALQALSNCPPLTHYF-LD--CGGLARTDK--------KPALCKSYQ 196

  Fly   325 NVLKALWTCKNESDH--STSFKAVVDRYGTQFRSSTQHDAQEFLFWLLDKVHEDLNTASKRRYKS 387
            .::..:|. ||....  .|:....:......||..:|.||||||..|:|.:||:|    |.:...
Frog   197 KLMSDIWH-KNRPGFVIPTNLFQGIKSVNPTFRGYSQQDAQEFLRCLMDVLHEEL----KEQIVE 256

  Fly   388 LKNSYGRSDEVIAAETL-ANHIRCNNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCISVQLPQ 451
            ::..   :...|..|.| .:..:.:|.|...      .|..:....|.:|....         .:
Frog   257 VEED---AQTGIVEENLDEDKSQSDNDFHSC------DSGSSSDHAESESRKLS---------EE 303

  Fly   452 LTQQTIFVTVVYMTRLPRQVRMGLRVPAGSPIVALREQLQADTGI----EGSRMVLVDLNAEGFT 512
            ||:.|:.:                            .:.|.|..|    :..:....:||...|.
Frog   304 LTESTMLI----------------------------HEDQKDVEICKTWQKEKKFSNNLNQNHFL 340

  Fly   513 RVFYDTQPVETLSSIETIYCIEVPAATPVAKAATPSETGDKSAPTAVTPSPAAAQSQADLLLLVA 577
            :.|    .....|:||...|::    ....|....|:..|.:|...:...|.   ||..||
Frog   341 QDF----EKNIQSTIEESECLK----QETVKVQIQSKAADFTAEVNMNDLPT---SQTPLL---- 390

  Fly   578 NVYRAKDGADITRFGAPFSMKAPRDCSYQDLQKRMLREMAPLLKPEVFSYATPLAEMFRIRLQDP 642
                 .:||......:|     |:..:.....|: :..:.|..|.:...|.:.:|::|
Frog   391 -----NEGATTHLSSSP-----PKPGAVWTGHKK-VPGLCPAKKRKQKKYHSVIADIF------- 437

  Fly   643 SADPDTYLEQVEHPLLTEMIDMALSVLSSEAGPQHIKLLLEWSSPEAHFISKQQDTEEAVVEHES 707
               ..|.:..|: .|..:.:.:.|...                          ||....:...|.
Frog   438 ---DGTIVSSVQ-CLTCDRVSVTLETF--------------------------QDLSLPIPGKED 472

  Fly   708 VARLSASKPSDT------------------------------AALTLEQCLEHYTKAETLSAEDA 742
            :|:|.:|....:                              ..:||:.||..:...:.|..::.
Frog   473 LAKLHSSSHQSSLVKAGSCGEAYAPQGWIAFFLEYFKSWFWGPTVTLQDCLAAFFARDELKGDNM 537

  Fly   743 WRCPHCQQYLPVVKTLGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFDMSPHLARG 807
            :.|..|::....||...:...|:||.:|.|||| |:..  .:.|:.|.|.|||...|:.|.||:
Frog   538 YSCEKCKKLRNGVKFCKVQKFPEILCIHLKRFR-HELM--FSTKIGTHVSFPLEGLDLQPFLAK- 598

  Fly   808 VHESASSSLGMGTGIGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTRYDLYAVCYHQGDTLET 872
                                            ||.|..:.         |||.:|..|.| |..:
Frog   599 --------------------------------DSPSQIVT---------YDLLSVICHHG-TASS 621

  Fly   873 GHYTAACKNPYDRQWYKFDDQRVSKVPEDDIEQDIINNEAYMLFYQRRSVDAGECSGSSSNSGDH 937
            |||.|.|:|..:..||:||||.|::|.|..::    |.|||:|||::
Frog   622 GHYIAYCRNNLNNLWYEFDDQSVTEVSEATVQ----NAEAYVLFYRK------------------ 664

  Fly   938 WVSRIAPASSSSASSTSGKEREPVKLEENTESPAAVEVTEKAQSKPVDIVCQDKAKGTAD-GPDA 1001
                        ||..:.|||..|....|...|:.::.....|       ..:|.|..|: ||.:
Frog   665 ------------ASEEAQKERRRVSCLLNIMEPSLLQFYISRQ-------WLNKFKTFAEPGPIS 710

  Fly  1002 DQEQTTVPHDLQIEELAFADADVDTSLGETI---------------------KAEVNLAAKDEPK 1045
            :.:...:...:...:.:|.: |:...|.:.|                     ..:..:...::.:
Frog   711 NNDFLCIHGGVPPRKASFIE-DLVVMLPQNIWDYLYSRYGGGPAVNHLYVCYTCQTEMEKIEKRR 774

  Fly  1046 KVEVEEATPIFAMDEDGSEARQEKK----------------EECVKKEDELSEAPDVSELTAESK 1094
            |:|:|....:       ::|.||::                |..||.:|.....|..:...|.:|
Frog   775 KMELETFIRL-------NKAFQEEESPAVIYCISMQWFREWEGFVKSKDSDPPGPIDNTKIAAAK 832

  Fly  1095 TNGHVSSSSSSSSSESS 1111
            . ||::....:.|.:.|
Frog   833 C-GHITLRQGADSGQIS 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	44/122 (36%)
		Peptidase_C19	266..>461	CDD:271592	55/197 (28%)
		Peptidase_C19R	<713..918	CDD:239139	60/234 (26%)
usp33	NP_001016228.1	zf-UBP	30..90	CDD:280334
		UCH	147..662	CDD:278850	153/689 (22%)
		Peptidase_C19	148..>178	CDD:271592	18/30 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	268..311		10/57 (18%)
		Peptidase_C19R	430..663	CDD:239139	71/319 (22%)
		DUSP	684..764	CDD:197831	11/87 (13%)
		DUSP	790..871	CDD:197831	12/60 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910