Protein Alignment Usp15-31 and usp33

DIOPT Version :9

• Sequence 1: NP_611959.2
• Gene: Usp15-31 / 37954
• FlyBaseID: FBgn0050421
• Length: 1272
• Species: Drosophila melanogaster
• Sequence 2: NP_998392.1
• Gene: usp33 / 406508
• ZFINID: ZDB-GENE-040426-2323
• Length: 897
• Species: Danio rerio
• Alignment Length: 1198
• Identity: 235/1198 - (19%)
• Similarity: 398/1198 - (33%)
• Gaps: 448/1198 - (37%)

  Fly   108 SHTAISSCVGGGRGRSGSIVSLSSYEAPFISSTNNNTTTASNGNNNNSSSSNINSKRTR---ALR 169
            ||.....|..||               |.:.:...|..:......:::..|.::|:.||   .:.
Zfish    27 SHGQCQDCKVGG---------------PNLWACLENGCSYVGCGESHADHSTVHSQETRHNLTVN 76

  Fly   170 RSSFRKFLNRIAQHLSSTVNVVSEEKHSPANRI--AFIEIVPFYTGCWRRKEANKHGQPSVSGSS 232
            .::.|.:.      .:.|..|..|.|..|..::  |...:.|..|.|   ::.|..|.|:
Zfish    77 LTTLRVWC------YACTKEVFLERKLGPHKQLPNAAKAVSPVQTPC---QDLNTPGSPT----- 127

  Fly   233 SGGGGGAGGPGGGERVPPIGGYQWPAD------------QTPGVMGLKNHGNTCFMNAVLQCLSH 285
                        ..|||..|    ..|            :|.|:.||||.||||:|||.||.||:
Zfish   128 ------------SLRVPSAG----TCDDLDMETEEEDELRTRGLTGLKNIGNTCYMNAALQALSN 176

  Fly   286 TDILAEYFVLDQYKADLKRRNKINSRKFGTKGELTEQLANVLKALWTCKNESDH--STSFKAVVD 348
            ...|.::|        |:....:.:.|   |..|.:....::..||. ||.:.:  .|:....:.
Zfish   177 CPPLTQFF--------LECGGLVKTDK---KPALCKSYQKLVTDLWH-KNRNSYVVPTNLFQGIK 229

  Fly   349 RYGTQFRSSTQHDAQEFLFWLLDKVHEDLNTASKRRYKSLKNSYGRSDEVIAAETLA---NHIRC 410
            .....||..:|.|:||||..|:|::||:|        |.|.......::.:|.:...   ||.:.
Zfish   230 AVNPMFRGYSQQDSQEFLRCLMDQLHEEL--------KELIPEPEDPNQAVAMDDSPDEDNHSQS 286

  Fly   411 NNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCISVQLPQLTQQTIFVTVVYMTRLPRQVRMGL 475
            ::          |:|..:|...::..|.                                   |.
Zfish   287 DD----------FQSCESCGSSDRADNE-----------------------------------GP 306

  Fly   476 RVPAGSPIVALREQLQADTGIEGSRMVLVDLNAEGFTRVFYDTQPVETLSSIETIYCIEVPAATP 540
            |||               ..|..:.|::.:.|...     .|.|..:.|  |..:|
Zfish   307 RVP---------------EDINEAEMLMPEQNQNN-----RDWQKEKNL--INNLY--------- 340

  Fly   541 VAKAATPSETGDKSAPTA-----VTPSPAAAQSQ---ADLLLLVANVYRAKDGADITRFGAPFSM 597
              :|.:..:. ||...|.     :..|..|.::|   :|..:.|::..|.:.........:..|.
Zfish   341 --RAGSHGDL-DKDVDTTSDSRPIISSQGAIKAQGRTSDSEIQVSSTVRPQSPTGNEGITSRLSS 402

  Fly   598 KAPRDCSYQDLQKRMLREMAPLLKPEVFSYATPLAEMFRIRLQDPSADPDTYLEQVEHPLLTEMI 662
            ..|:..::.:|..  ..:..|:..|                       ..|..::..|.:::|:.
Zfish   403 SPPKSSAWPNLSS--THKKVPMFTP-----------------------TKTKRQRKYHSIISEVF 442

  Fly   663 D----MALSVLSSEAGPQHIKLLLEWSSPEAHFISKQQDTEEAVVEHESVARLSASKPSDTA--- 720
            |    .::..|:.:    .:.:.||      :|    ||....:...|.:|:|.:|. ..||
Zfish   443 DGTIVSSVQCLTCD----RVSVTLE------NF----QDISLPIPGKEDLAKLHSSS-HQTALVK 492

  Fly   721 ----------------------------ALTLEQCLEHYTKAETLSAEDAWRCPHCQQYLPVVKT 757
                                        .:||:.||..:...:.|..::.:.|..|::....||.
Zfish   493 AGSCGEAYAPQGWIAFVMEYIKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF 557

  Fly   758 LGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFDMSPHLARGVHESASSSLGMGTGI 822
            ..:.|||:||.:|.|||| |:..  .:.|:.|.|.|||...:|.|.||:
Zfish   558 CKVQSLPEILCIHLKRFR-HELM--FSTKIGTHVSFPLEGLEMQPFLAK---------------- 603

  Fly   823 GLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTRYDLYAVCYHQGDTLETGHYTAACKNPYDRQW 887
                             ||.:.|         |.|||.:|..|.| |..:|||.|.|:|..::.|
Zfish   604 -----------------DSSALT---------TTYDLLSVICHHG-TASSGHYIAYCRNELNQLW 641

  Fly   888 YKFDDQRVSKVPEDDIEQDIINNEAYMLFYQRRSVDAGECSGSSSNSGDHWVSRIAPASSSSASS 952
            |:||||.|::|.|..::    |.|||:|||::                              ::.
Zfish   642 YEFDDQSVTEVSESCVQ----NAEAYVLFYKK------------------------------SND 672

  Fly   953 TSGKEREPVKLEENTESPAAVE--VTEK--------AQSKPV---DIVC------QDKAKGTAD- 997
            .:.|||..|....|...|:.::  |:.:        |:..|:   |.:|      .:||....|
Zfish   673 ETQKERRKVTSLFNMMEPSLLQFYVSRQWLNKFKTFAEPGPISNHDFLCAHGGIPPNKATYIDDL 737

  Fly   998 ------------------GPDADQEQTTVPHDLQ--IEELAFADADVDTSLGETIKAEVNLAAKD 1042
                              ||..:  ...|.|..|  ||:|.           :..|.|:::..:
Zfish   738 VLMIPQNVWDHLYSRYGGGPAVN--HLYVCHTCQNEIEKLE-----------KRRKNELDMFVR- 788

  Fly  1043 EPKKVEVEEATPIFAMDEDGSEARQEKKEECVKKE-----DELSEAPDVSELTAESKTNGHVSSS 1102
             ..|...||.:|:...              |:..:     :...:..|:
Zfish   789 -LNKAFQEEESPVVIY--------------CISMQWFREWESFVKGKDI---------------- 822

  Fly  1103 SSSSSSESSLSSRSSPRSLSTSVTAASTLQSKFNGHMSAAPALFNGNGNTSQLSSSLQLSRHVLH 1167
                         ..|..:..|..|.:.     |||::..|...:|     |:|..   :.:.||
Zfish   823 -------------DPPGPIDNSKIAVNK-----NGHITLKPGADSG-----QISEE---TWNFLH 861

  Fly  1168 NHQWHGSRSSVSAVENATQHQQQQAAAS 1195
            |  .||. ..|..|..:..||:.:.:.|
Zfish   862 N--IHGG-GPVVTVRPSVSHQESETSQS 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	40/122 (33%)
		Peptidase_C19	266..>461	CDD:271592	48/199 (24%)
		Peptidase_C19R	<713..918	CDD:239139	65/235 (28%)
usp33	NP_998392.1	zf-UBP	31..91	CDD:280334	11/80 (14%)
		UCH	155..667	CDD:278850	152/700 (22%)
		Peptidase_C19	156..>418	CDD:271592	73/362 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..308		9/91 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..420		12/79 (15%)
		Peptidase_C19R	435..668	CDD:239139	77/297 (26%)
		DUSP	687..769	CDD:197831	13/83 (16%)
		DUSP	795..879	CDD:197831	22/142 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	875..897		3/12 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900