DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp15-31 and Usp5

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_001246589.1	Gene:	Usp5 / 38375	FlyBaseID:	FBgn0035402	Length:	827	Species:	Drosophila melanogaster

Alignment Length:	1033	Identity:	193/1033 - (18%)
Similarity:	316/1033 - (30%)	Gaps:	386/1033 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 REQSE--GDAATTHLTTTATATTGAIVAA--GVTTTLPATKTTTTAADT----STTNAAKK--IR 62
            ||.::  |:....|:....|...||.:.|  ..:...|..|.|..|...    :.::.|||  |:
  Fly    58 REYADKTGNRVFLHIQRVKTIKEGADMEAECAESEAGPERKITRLAIGVEGGYNESDMAKKYEIK 122

  Fly    63 RTFSM--------------PRNPFRWTRKFKTAVAVTSS-AGAENDNESGKNNGARERRGSHTA- 111
            .|:|:              |..|.|.|:..:..:|..|: |..|.....|..:| ..|:.|..|
  Fly   123 DTYSIVVAPHLDKKLPYPDPELPMRVTQSVEAILAADSAIAKLEKATLMGTWDG-EVRQASKYAD 186

  Fly   112 -ISSCVGGGRGRSGSIVSLSSYEAPFISSTNN---NTTTAS--------NGNNNNSSSSN----- 159
             :.....|.|      :..|.::......|||   |.|..|        :|:..|..:..
  Fly   187 NLQQLDNGKR------IPPSGWQCEKCDLTNNLWLNLTDGSIMCGRKFFDGSGGNDHAVEHYRVT 245

  Fly   160 -----INSKRTRALRRSSFRKFLN-------RIAQHLSS-TVNVVSEEKHSPANRIAFIEI---V 208
                 :......|..:|....:..       .:.:|||. .:|:.:.:|    :..:.:|:   :
  Fly   246 GFPLAVKLGTITADGKSDVFSYPEDEMVLDPHLERHLSHFGINMAAMKK----SEKSMVELELDI 306

  Fly   209 PFYTGCWRRKEANKHGQPSVSGSSSGGGGGAGGPGGGERVPPIGGYQWPADQTPGVMGLKNHGNT 273
            ....|.|          .:::.|.|             .:.|:.|        ||..|::|.||:
  Fly   307 NQRIGEW----------TALTESES-------------ELQPVAG--------PGYTGMRNLGNS 340

  Fly   274 CFMNAVLQCLSHTDILAEYFV-------LDQYKADLKRRNKINSRKFGT---KGELTEQLANVLK 328
            |::|:|:|.|.......:.||       ..::.:|......|...|.||   .|:.:....|.|
  Fly   341 CYINSVMQVLFVIPDFQQRFVGTGAERYFKEFPSDPANDFNIQMAKLGTGLQSGKYSSIAENTL- 404

  Fly   329 ALWTCKNESDHSTS-----FKAVVDRYGTQFRSSTQHDAQEF---LFWLLDKVHEDLNTASKRRY 385
                   ::||||.     ||.:|.:....|.:..|.||.:|   |..|||
  Fly   405 -------DTDHSTGISPAMFKNIVGKNHPDFSTKQQQDANDFYLHLLTLLD-------------- 448

  Fly   386 KSLKNSYGRSDEVIAAETLANHIRCNNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCISVQLP 450
               :||..:::...|.:.|..                                 |...|::..
  Fly   449 ---RNSRNQTNPADALKFLLE---------------------------------DRVECLASH-- 475

  Fly   451 QLTQQTIFVTVVYMTRLPRQVRMGLRVPAGSPIVALREQLQADTGIEGSRMVLVDLNAEGFTRVF 515
                     .|.|.||.....|:        |:
  Fly   476 ---------KVKYNTREEYSFRL--------PV-------------------------------- 491

  Fly   516 YDTQPVETLSSIETIYCIEVPAATPVAKAATPSETGDKSAPTAVTPSPAAAQSQADLLLLVANVY 580
                |::..::::     ||.......|||  .|||.
  Fly   492 ----PLDKATNLD-----EVREFQERKKAA--RETGQ---------------------------- 517

  Fly   581 RAKDGADITRFGAPFSMKAPRDCSYQDLQKRMLREMAPLLKPEVFSYA----------TPLAEMF 635
            |..| .||.|...|             ||..:.|...|.|..:.:|.|          |.||.|
  Fly   518 RLPD-RDIVRHKVP-------------LQACLERFFGPELIEQFYSTAIGSKTNARKITRLATM- 567

  Fly   636 RIRLQDPSADPDTYLEQVEHPLLTEMIDMALSVLSSEAGPQHIKL---------LLEWSSPEAHF 691
                      ||..           ||.:....|..:..|:.:.:         |..|.|
  Fly   568 ----------PDCL-----------MIHVGKFTLGDDWVPKKLDVSVDMPDELDLSNWRS----- 606

  Fly   692 ISKQQDTEEAVVE--HESVARLSASKPSDTAALTL----EQCLE--HYTKAETLSAEDAWRCPH- 747
            ....|..|||:.|  .|.| :.:..:...:..||:    |.|..  ::||...|.|...|...|
  Fly   607 AGGLQPGEEALPEPATEEV-KFAFDEAVMSELLTMGFPPEACKRACYHTKNSGLEAASNWLMEHI 670

  Fly   748 -----CQQYLPVVKTLGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKF-------PLTAFDM 800
                 .:.::....::|     |.....|       ...|::..:...:.|       .|.|.|.
  Fly   671 ADEDISEPFVVPNNSIG-----DCAANQF-------VANPESLAMLMSMGFDERQAVAALKATDG 723

  Fly   801 SPHLARGVHESASSSLGMGTGIGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTR--YDLYAVC 863
            :...|.....|.:.|:|:           .:....|.|..:.:|:..::.:.:|.|  |.|.|..
  Fly   724 NVERATDWIFSHADSIGV-----------EDAAPAANSSAAAASSTPNKTNYRDGRGKYRLVAFI 777

  Fly   864 YHQGDTLETGHYTAACKNPYDRQWYKFDDQRVSKV--PEDDIEQDIINNEAYMLFYQR 919
            .|.|.:.:.|||  .|......:|..|:|.:|:|.  |..|:        .|:..|.|
  Fly   778 SHMGTSAQVGHY--VCHIRKKGEWVIFNDSKVAKSQNPPKDL--------GYLYLYMR 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	37/138 (27%)
		Peptidase_C19	266..>461	CDD:271592	41/212 (19%)
		Peptidase_C19R	<713..918	CDD:239139	44/227 (19%)
Usp5	NP_001246589.1	UBP14	24..825	CDD:227532	192/1031 (19%)
		zf-UBP	204..278	CDD:280334	10/73 (14%)
		Peptidase_C19B	333..823	CDD:239123	133/712 (19%)
		UBA1_UBP5_like	631..674	CDD:270480	10/42 (24%)
		UBA2_UBP5	696..737	CDD:270569	7/40 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456891
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930