DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp15-31 and Usp19

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	XP_006243855.1	Gene:	Usp19 / 361190	RGDID:	1303276	Length:	1359	Species:	Rattus norvegicus

Alignment Length:	1193	Identity:	274/1193 - (22%)
Similarity:	416/1193 - (34%)	Gaps:	394/1193 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 RKFKTAVAVTSSAGAENDNESGKNNGARERRGSHTAISSCVG-------GGRGRSGSIVSLSSYE 133
            |:.|........|....:..||.:.||:....:..|:..|.|       .|.|..|...|..|..
  Rat   174 RRAKQEARNQKRAQGRGEVGSGASPGAQAGPSAKRAVHLCRGPEGEGSMDGPGPQGDAPSFLSDS 238

  Fly   134 APFISSTNN------NTTTASNGNNNNSSSSNINSKRTRALRRSSFRKFLNR------------- 179
            |..:.:...      |..|:..|:..|.:...:  ::|.:.|..|....:.|
  Rat   239 ATQVEAEEQLHVPPVNPQTSLLGSEKNLALLTV--EKTVSPRSDSVSPVMIRNRDPEKDDHFKEE 301

  Fly   180 ---------IAQHLSSTVN-------------------VVSEEKHSPANRIAFIE---------- 206
                     :|....|.||                   |..:|.....:|:.|.|
  Rat   302 MAVGADPAALADEPESMVNLAFVKNDSYEKGPDSVVVHVYVKESRRDTSRVLFREQDFTLIFQTR 366

  Fly   207 ---IVPFYTGC-------W--------------------------RRKEANKHG---QPSVSGSS 232
               .:..:.||       |                          |::::.:.|   .|:..|:.
  Rat   367 DGNFLRLHPGCGPHTIFRWQVKLRNLIEPEQCTFCFTASRIDICLRKRQSQRWGGLEAPATRGAV 431

  Fly   233 SGG----------------GGG------------------------AGGPGGGERVP-------- 249
            .|.                |||                        :|..|...|.|
  Rat   432 GGAKVAVPTGPTPLDSTPPGGGPLPLTGQEEARAVEKEKPKARSEDSGLDGVVARTPLEHVTPKP 496

  Fly   250 -------------------PIGGYQWPADQ-------TPGVMGLKNHGNTCFMNAVLQCLSHTDI 288
                               |:.|.....|:       .||..||.|.|||||||:|:|.||:|..
  Rat   497 EPHLASPKPTCMVPPMPHSPVSGDSVEEDEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRE 561

  Fly   289 LAEYFVLDQYKADLKRRNKINSRKFGTKGELTEQLANVLKALWTCKNESDHSTSFKAVVDRYGTQ 353
            |.::|....::|::...|.:     ||.|.|....|.:|:|||...:::...:..||:|....:|
  Rat   562 LRDFFHDRSFEAEINYNNPL-----GTGGRLAIGFAVLLRALWKGTHQAFQPSKLKAIVASKASQ 621

  Fly   354 FRSSTQHDAQEFLFWLLDKVHEDLNTASKRRYKSLKNSYGRSDEVIAAETLANHIRCNNSFVQAV 418
            |....|||||||:.:|||.:|||||....:.|....:|.||.|||:|.|....|...|:||:..:
  Rat   622 FTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDL 686

  Fly   419 FQAQFRSSLTCPRCEKQSNTFDPFHCISVQLPQLTQQTIFVTVVYMTRLPRQVRMGLRVPA---G 480
            ||.|::|.|.||.|.|.|.|||||..:.|.|||  :|.: :.:.|..|.|....:...|..   .
  Rat   687 FQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQ--KQKV-LPIYYFAREPHSKPIKFLVSVSKEN 748

  Fly   481 SPIVALREQLQADTGIEGSRMVLVDLNAEGFTRVFYDTQPVETLSSIETIYCIEVPAATPVAKAA 545
            |....:.|.|.....::...:.|.::....|.|||..:..::.:|..:.:.|.|:.:.....:..
  Rat   749 SSASEVLESLSQSVHVKPESLRLAEVIKNRFHRVFLPSHSLDAVSPTDVLLCFELLSPELAKERV 813

  Fly   546 TPSETGDKSAPTAVTPSPAAA-----QSQADLLLLVANVYRA------------KDGADITR--- 590
            ...|...:....::..|..||     ||:.:.|......||.            .|...:.|
  Rat   814 VVLEVQQRPQVPSIPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQFCQKTHWPDHKGLCRPEN 878

  Fly   591 FGAPFSMKAPRD-CSYQDLQK--------------------RM-LREMAP--------------- 618
            .|.||.:..|.. .:|..|.:                    || |...:|
  Rat   879 IGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTSSLEAGD 943

  Fly   619 ----LLKPEVFSYATPLAE-------MFRIRLQDPSAD----PDTYLEQVEHPLLTEMIDMALSV 668
                .::|......||:||       |:      |.||    |.|  ..:...:|........|:
  Rat   944 SEREPIQPSELQLVTPVAEGDTGAHRMW------PPADRGPVPST--SGISSEMLASGPMEGCSL 1000

  Fly   669 LSSE---------AGPQHIKLLLEWSSPEAHFI------SKQQDTE------------------- 699
            |:.|         .|.||.:..:...:|: .||      |::|..|
  Rat  1001 LAGERVSRPEAAVPGYQHSRESVSAHTPQ-FFIYKIDASSREQRLEDKGDTPLELGDDCSLALVW 1064

  Fly   700 ---EAVVEHESVARL---------SASKPSDTAALTLEQCLEHYTKAETLSAEDAWRCPHCQQYL 752
               |.:.|...||..         ||.:.:.....||:|||..:|:.|.|:.|:||.||.|:|:.
  Rat  1065 RNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHR 1129

  Fly   753 PVVKTLGLWSLPDILVVHFKRF-------RQHQSKGPQAAKLTTMVKFPLTAFDMSPHLARGVHE 810
            ...|.|.||.||::|:|..|||       |.         |:..:|:||:...|:|...
  Rat  1130 EASKQLLLWRLPNVLIVQLKRFSFRSFIWRD---------KINDLVEFPVRNLDLSKFC------ 1179

  Fly   811 SASSSLGMGTGIGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTRYDLYAVCYHQGDTLETGHY 875
                       ||          :|...:.|               ||||||..|.|..: .|||
  Rat  1180 -----------IG----------QKEEQLPS---------------YDLYAVINHYGGMI-GGHY 1207

  Fly   876 TAACKNPYDRQ-------WYKFDDQRVSKVPEDDIEQDIINNEAYMLFYQRRS--VDAGECSGSS 931
            ||..:.|.||.       |..|||..|:.|.    |..::...||:|||:||:  |:....:..:
  Rat  1208 TACARLPSDRSSQRSDVGWRLFDDSTVTTVD----ESQVVTRYAYVLFYRRRNSPVERPPRAAHA 1268

  Fly   932 SNSGDHWVSRIAPASSSSASSTS 954
            .:..|     :.||:.::||..|
  Rat  1269 EHHPD-----LGPAAEAAASQAS 1286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	50/120 (42%)
		Peptidase_C19	266..>461	CDD:271592	81/194 (42%)
		Peptidase_C19R	<713..918	CDD:239139	65/218 (30%)
Usp19	XP_006243855.1	p23_like	58..140	CDD:107220
		p23_CS_SGT1_like	327..423	CDD:107223	10/95 (11%)
		USP19_linker	414..536	CDD:293210	14/121 (12%)
		Peptidase_C19	539..>725	CDD:271592	81/193 (42%)
		USP7_C2	739..>795	CDD:291217	10/55 (18%)
		zf-MYND	832..874	CDD:280009	8/41 (20%)
		Peptidase_C19R	<1096..1253	CDD:239139	64/212 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	1	1.000	-	-		FOG0000596
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820