DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp15-31 and Usp33

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	XP_038958424.1	Gene:	Usp33 / 310960	RGDID:	1307848	Length:	909	Species:	Rattus norvegicus

Alignment Length:	699	Identity:	168/699 - (24%)
Similarity:	258/699 - (36%)	Gaps:	200/699 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 GVMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLKRRNKINSRKFGTKGELTEQLANVL 327
            |:.||||.||||:|||.||.||:...|.::| ||  ...|.|.:|        |..:.:....::
  Rat   151 GLTGLKNIGNTCYMNAALQALSNCPPLTQFF-LD--CGGLARTDK--------KPAICKSYLKLM 204

  Fly   328 KALWTCKNESDHSTSFKAVV--------DRYGTQFRSSTQHDAQEFLFWLLDKVHEDLNTASKRR 384
            ..||       |.:...:||        ......||..:|.||||||..|:|.:||:
  Rat   205 TELW-------HKSRPGSVVPANLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEE-------- 254

  Fly   385 YKSLKNSYGRSDEVIAAETLANHIRCNNSFVQAVFQAQFRSSLTCPRC----EKQSNTFDPFHCI 445
               ||......:|...|.|....:....|.....||       :|..|    ||..|     ..:
  Rat   255 ---LKEQVMEIEEEPQALTSEETVEEEKSQSDVDFQ-------SCESCSSSSEKGEN-----ESV 304

  Fly   446 SVQLPQLTQQTIFVTV----VYMTRLPRQVRMGLRVPAGSPIVALREQLQADTGIEGSR-----M 501
            |...|:.:.:|..:..    :.|.:..::.:|            ..:..:||:..|..:     .
  Rat   305 SKGGPEDSTETTMLIQDEEDLEMAKDWQKEKM------------CNKSNKADSDGEPDKDRDTVC 357

  Fly   502 VLVDLNAEGFTRVFYDTQPVETLSSIETIYCIEVPAATPVAKAATP--SETGDKSAP--TAVTPS 562
            ..||||::...:|....:..|.::.:. :..:..|...|..::..|  |.:..||..  ..:||.
  Rat   358 ETVDLNSQETVKVQIHGRASEYITDVH-LNDLSTPQILPSNESVNPRLSASPPKSGNLWPGLTPP 421

  Fly   563 PAAAQSQADLLLLVANVYRA--KDGADITRFGAPFSMKAPRDC----SYQDLQKRMLREMAPLLK 621
            ...|||.:.........||:  .|..|.|...:...:...|..    ::|||.
  Rat   422 HKKAQSSSPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLS------------ 474

  Fly   622 PEVFSYATPLAEMFRIRLQDPSADPDTYLEQVEHPLLTEMIDMALSVLSSEAGPQHIKLLLEWSS 686
                             |..|..:....|....||.:         |.:...|        |..:
  Rat   475 -----------------LPIPGKEDLAKLHSSSHPTI---------VKAGSCG--------EAYA 505

  Fly   687 PE---AHFISKQQDTEEAVVEHESVARLSAS-KPS--DTAALTLEQCLEHYTKAETLSAEDAWRC 745
            |:   |.|:             |.|.|...| .||  ....:||:.||..:...:.|..::.:.|
  Rat   506 PQGWIAFFM-------------EYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSC 557

  Fly   746 PHCQQYLPVVKTLGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFDMSPHLARGVHE 810
            ..|::....||...:...|:||.:|.|||| |:..  .:.|::|.|.|||...|:.|.||:
  Rat   558 EKCKKLRNGVKFCKVQKFPEILCIHLKRFR-HELM--FSTKISTHVSFPLEGLDLQPFLAK---- 615

  Fly   811 SASSSLGMGTGIGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTRYDLYAVCYHQGDTLETGHY 875
                                         ||         .|:...|||.:|..|.| |..:|||
  Rat   616 -----------------------------DS---------PAQIVTYDLLSVICHHG-TASSGHY 641

  Fly   876 TAACKNPYDRQWYKFDDQRVSKVPEDDIEQDIINNEAYMLFYQRRSVDA 924
            .|.|:|..:..||:||||.|::|.|..::    |.|||:|||::.|.:|
  Rat   642 IAYCRNNLNNLWYEFDDQSVTEVSESTVQ----NAEAYVLFYRKSSEEA 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	42/127 (33%)
		Peptidase_C19	266..>461	CDD:271592	57/206 (28%)
		Peptidase_C19R	<713..918	CDD:239139	62/207 (30%)
Usp33	XP_038958424.1	zf-UBP	30..89	CDD:396634
		UCH	153..679	CDD:395355	163/688 (24%)
		DUSP	701..770	CDD:416436
		DUSP	807..891	CDD:197831
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910