DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp15-31 and Usp32

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	XP_038941969.1	Gene:	Usp32 / 303394	RGDID:	1306657	Length:	1683	Species:	Rattus norvegicus

Alignment Length:	899	Identity:	200/899 - (22%)
Similarity:	329/899 - (36%)	Gaps:	262/899 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 WPADQT----------------PGVMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLKR 304
            ||.:.:                .|..||.|.|||||||:.:||:|:|..|.:||:..::..:|.|
  Rat   788 WPEEMSFIANSSKIDRHKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNR 852

  Fly   305 RNKINSRKFGTKGELTEQLANVLKALWTCKNESDHSTSFKAVVDRYGTQFRSSTQHDAQEFLFWL 369
            .|.|     |.||.:.:...::::.||:...::......:..:.:|..:|....|.|:||.|.:|
  Rat   853 TNPI-----GMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFL 912

  Fly   370 LDKVHEDLNTASKRRYKSLKNSYGRSDEVIAAETLANHIRCNNSFVQAVFQAQFRSSLTCPRCEK 434
            ||.:|||||...::.|..||:|.||.|..:|||...||:|.|.|.|..:|..|.||.:.|..|..
  Rat   913 LDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGH 977

  Fly   435 QSNTFDPFHCISVQLPQLTQQTIFVTVVYMTRLPRQVRMGLRVPAGSPIVALREQLQADTGIEGS 499
            .|..||||:.:|:.||..:...:.:||:.:.. ...:|.|||:........|::||....|::..
  Rat   978 ISVRFDPFNFLSLPLPMDSYMHLEITVIKLDG-TTPIRYGLRLNMDEKYTGLKKQLSDLCGLKSE 1041

  Fly   500 RMVLVDLNAEGFTRVFYDTQPVETLSSIETIYC-IEVP-AATPVAKAATPSETGDKSAPT----- 557
            :::..::::........|.|.|..  |:....| .|:| .|:||: |.:|.:|...|:|:
  Rat  1042 QILFAEVHSSNIKNFPQDNQKVRL--SVSGFLCAFEIPIPASPVS-ACSPIQTDCSSSPSTNGLF 1103

  Fly   558 AVTPS------------------PAAAQSQADLLLL---------------VANVYRAKDGADI- 588
            .||.:                  |...:..|...::               :..|:|.....::
  Rat  1104 TVTTNGDLPRPIFIPNGMPNTVVPCGTEKNATNGIVNGHMPPLPDDPFTGYIIAVHRKMMRTELY 1168

  Fly   589 ---------TRFGAPFSMKAPRDCSYQDLQKRMLREMAPLLKP--------------EVFSYATP 630
                     :.||.|..:........:||...:..:::.|..|              :...|..|
  Rat  1169 FLSSQKNRPSLFGMPLIVPCTVHTRKKDLYDAVWIQVSRLASPLPPQEASNHAQDCDDSMGYQYP 1233

  Fly   631 LAEMFRIRLQDPSADPDTYLEQVEHPLLTEMIDMALSVLSSEAGPQHIKLLLEWSSPEAHFISKQ 695
                |.:|:.....:...:.     |.........:......|...:..:.::| .|.|..:..|
  Rat  1234 ----FTLRVVQKDGNSCAWC-----PWYRFCRGCKIDCGEDRAFIGNACIAVDW-DPTALHLRYQ 1288

  Fly   696 QDTEEAVVEHESVARLSASKPSDTAALTLEQCLEHYTKAETLSAEDAWRCPHCQQYLPVVKTLGL 760
            ...|..|.|||||.:   |:.:....:.|:.||..:|..|.|...:.:.|..|:.:....|.|.|
  Rat  1289 TSQERVVEEHESVEQ---SRRAQAEPINLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDL 1350

  Fly   761 WSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFD-------------------------- 799
            |.||.||::|.|||:....:..::.|:   ||||..:||
  Rat  1351 WRLPPILIIHLKRFQFVNGRWIKSQKI---VKFPRESFDPSAFLVPRDPTLCQHKPLTPQGDDVS 1412

  Fly   800 -------------------------------MSPHLARGVHESASSS------------------ 815
                                           :|.::......|.|||
  Rat  1413 ELPIPAGDVKKVDVQNPAGEEDVLLSKSPSSLSANITSSPKGSPSSSRKSGASCPSSKNSSPNSS 1477

  Fly   816 ---LGMGTG------IGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTR--------------- 856
               ||...|      ||....|.|:   |.....||.:.....|:..||.
  Rat  1478 PRTLGRNKGRLRLPQIGSKNKLSSS---KENLDASRENGAGQICELADTLNRGHVLGGSQPELVT 1539

  Fly   857 -------------------------------------------------YDLYAVCYHQGDTLET 872
                                                             |:|||:..|.| .|..
  Rat  1540 PLDHEITLANGFLYEHETCGNGYSNGQLGNHSEEDSTDDQREDTHSKPIYNLYAISCHSG-ILGG 1603

  Fly   873 GHYTAACKNPYDRQWYKFDDQRVSKVPEDDIEQDIINNEAYMLFYQRRSVDAGE 926
            |||....||| :.:||.::|....::..|:|:.|    .||:|||:::.:|..:
  Rat  1604 GHYVTYAKNP-NCKWYCYNDSSCKELHPDEIDTD----SAYILFYEQQGIDCAQ 1652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	42/120 (35%)
		Peptidase_C19	266..>461	CDD:271592	71/194 (37%)
		Peptidase_C19R	<713..918	CDD:239139	69/352 (20%)
Usp32	XP_038941969.1	FRQ1	254..404	CDD:227455
		UBP12	583..1395	CDD:227847	157/631 (25%)
		UCH	<1314..1643	CDD:395355	67/340 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820