DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp15-31 and ubp1

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_587999.1	Gene:	ubp1 / 2539228	PomBaseID:	SPCC16A11.12c	Length:	849	Species:	Schizosaccharomyces pombe

Alignment Length:	1017	Identity:	225/1017 - (22%)
Similarity:	379/1017 - (37%)	Gaps:	314/1017 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ADTSTTNAAKK-----IRRTFSMP---------RNPFRWTRKFKTAVAV--------TSSAGAEN 92
            |.|:|.||:.:     |.:..|:|         .:..:| :|.|||..:        ......|.
pombe     2 ASTATQNASTRYSQIWIDQPASLPFQDSINLIKEDKEKW-KKEKTAFLIDYDWFEGYVDFIYGEG 65

  Fly    93 DN-----------ESGKNNGARERRGSHTAISSCV-----------GGGRGRSGSIVSLSSYEAP 135
            ||           |..:...:.|....::.:|:.:           |....|...:|.|::.:.|
pombe    66 DNPGPITQWRLLDEKNELKHSLEESIDYSIVSASLWHMLVEWFGLEGLAIERKVLLVGLAAEQKP 130

  Fly   136 FISSTNNNTT-----TASNGNNNNSSS----------------SNINSKRTRALRR--------- 170
            |:.....|.|     ...||.|.:.|.                |...|...|:|.:
pombe   131 FVDIYPINFTLHVLFDPINGENTSYSPLYQIDEPYHSDEPYAFSFSRSDTLRSLYKQVMEAFQIS 195

  Fly   171 --SSFRK-FLNRIAQHLSSTVNVVSEEKHSPANRIAFIEIVPFYTGCWRRKEAN----------K 222
              :|||. :||:  .:|||....:||....||     |.::..|..|....|.:          :
pombe   196 DGTSFRLWYLNK--SNLSSRFVSLSEFNDQPA-----IALLSEYAVCMTIFEIDIADGSLLLEFQ 253

  Fly   223 HGQPSVSGSSSGGGGGAGGPGGGERVPPIGGYQWPADQTP-----------GVMGLKNHGNTCFM 276
            |                  |.|          :|.:|...           |:.||.|.||:|:|
pombe   254 H------------------PNG----------EWLSDSITKEQNLTINKEIGLCGLYNLGNSCYM 290

  Fly   277 NAVLQCLSHTDILAEYFVLDQYKADLKRRNKINSRKFGTKGELTEQLANVLKAL-WTCKNESDHS 340
            |:.|||:.||..|.:||:.|.|:.|:...|.:     |..|::....|::||.: .|....|...
pombe   291 NSALQCMIHTHELTKYFLSDSYEKDINYNNPL-----GMMGKVALSYASLLKMIHHTADMHSVSP 350

  Fly   341 TSFKAVVDRYGTQFRSSTQHDAQEFLFWLLDKVHEDLNTASKRRYKSLKNSYGRSDEVIAAETLA 405
            :|||.::..:.|.|....|.|:|||:.:.||.:|||||....:.|....:.:  .:..:..:.:|
pombe   351 SSFKFIIGEFNTYFSGYRQQDSQEFIAFFLDGLHEDLNRIQIKPYFERPDLF--DEHPLHVQRVA 413

  Fly   406 N-----HIRCNNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCISVQLPQLTQQTIFVTVVYM- 464
            |     |.:.|:|.:..:||..::|:|.|..|.::|..||||..:::.||  |.......|||:
pombe   414 NQCWDIHTKRNDSIIVQLFQGMYKSTLECSICYQKSTAFDPFMYLTLPLP--TSAKWRHKVVYVP 476

  Fly   465 ---TRLPRQVRMGLRVPAGSPIVALR----EQLQADTGIEGSRMVLVDL----------NAEGFT 512
               |:.|  |.:.|.:...|.::.::    |:|| ..|:|...:...|:          |.:..:
pombe   477 PFGTQSP--VELYLELLMESTVIQMKFQATEKLQ-KMGLECGELTACDIYRGKVYKVLKNKDKIS 538

  Fly   513 RVFYDTQPVETLSSIETIYCIEVPAATPVAKAATPSETGDKSAPTAVTPSPAAAQSQADLLLLVA 577
            :..:....|....|  |...:.:|......:.|.|..
pombe   539 KKIHKWDHVVLYGS--TANGLTIPIVHGCKRPAMPGS---------------------------- 573

  Fly   578 NVYRAKDGADITRFGAPFSMKA-PRDCSYQDLQKRMLREMAPLLKPEVFSYATPLAEMFRIRLQD 641
              |::.|     .||.|..:.. .|:....||.|.                   :.|::|:
pombe   574 --YQSND-----VFGFPLQLNVRSRNVLTNDLVKE-------------------IVELYRV---- 608

  Fly   642 PSADPDTYLEQVEHPLLTEMIDMALSVLSSEAGPQHIKLLLEWSSPEAHFISKQQ--DTEEAVVE 704
             .|..|..:..::         :.|..:.|:||        :|...:...:.:.:  :.||.|::
pombe   609 -YAGIDVAIGTLQ---------LGLKRMESKAG--------KWECIKEIEVKRFEIVEEEEIVID 655

  Fly   705 HESVAR-----------------LSASKPSDTAALTLEQCLEHYTKAETLSAEDAWRCPHCQQYL 752
            .::|..                 :.........::|||.||..::|.|.|..:|:|.||.|:.:.
pombe   656 DKTVIMCLWNDQQYEKLFYNCEWIFEKIQFHMESITLEDCLLEFSKPEQLDLQDSWYCPGCKAFR 720

  Fly   753 PVVKTLGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFDMSPHLARGV--HESASSS 815
            |..|.|.:|.||.|||:|..||..|.....:..|...:|.:|:...::...|:..:  ||..||.
pombe   721 PATKRLEIWRLPKILVIHLNRFSGHGGDLRRRRKRRDLVVYPVFDLNLKQFLSPFIKDHEWLSSQ 785

  Fly   816 LGMGTGIGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTRYDLYAVCYHQGDTLETGHYTAACK 880
                                                 |...||||||..|.| .:..|||||..:
pombe   786 -------------------------------------KSMLYDLYAVDNHHG-FMSNGHYTAYAR 812

  Fly   881 NPYDRQWYKFDDQRVSKV-PEDDIEQDIINNEAYMLFYQRRS 921
            :...:.::||||..:.:: ||     ||:.:.||:|||:.::
pombe   813 DASSQTFFKFDDTAICEIDPE-----DIVTSSAYVLFYRAKN 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	45/132 (34%)
		Peptidase_C19	266..>461	CDD:271592	64/200 (32%)
		Peptidase_C19R	<713..918	CDD:239139	60/207 (29%)
ubp1	NP_587999.1	UBP12	1..849	CDD:227847	225/1015 (22%)
		DUSP	45..123	CDD:197831	10/77 (13%)
		Peptidase_C19	280..>472	CDD:271592	64/200 (32%)
		Peptidase_C19	280..>394	CDD:271592	44/118 (37%)
		Peptidase_C19R	<690..846	CDD:239139	60/198 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000596
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21646
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910