DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp15-31 and USP33

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_055832.3	Gene:	USP33 / 23032	HGNCID:	20059	Length:	942	Species:	Homo sapiens

Alignment Length:	690	Identity:	159/690 - (23%)
Similarity:	260/690 - (37%)	Gaps:	181/690 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 GVMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLKRRNKINSRKFGTKGELTEQLANVL 327
            |:.||||.||||:|||.||.||:...|.::| ||  ...|.|.:|        |..:.:....::
Human   183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFF-LD--CGGLARTDK--------KPAICKSYLKLM 236

  Fly   328 KALWTCKNESD--HSTSFKAVVDRYGTQFRSSTQHDAQEFLFWLLDKVHEDLNTASKRRYKSLKN 390
            ..||.......  .:|.|:. :......||..:|.||||||..|:|.:||:|
Human   237 TELWHKSRPGSVVPTTLFQG-IKTVNPTFRGYSQQDAQEFLRCLMDLLHEEL------------- 287

  Fly   391 SYGRSDEVIAAETLANHIRCNNSFVQAVFQA--QFRSSLTCPRCEKQSNTFDPFHCISVQLPQLT 453
                .::|:..|.....|....:..:...|:  .|:|..:|...::..|. :...|.|....:.|
Human   288 ----KEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAENE-NGSRCFSEDNNETT 347

  Fly   454 QQTIFVTVVYMTRLPRQVRMGLRVPAGSPIVALREQLQADTGIEGSRMVLVDLNAEG-FTRVFYD 517
                               |.::....:      .::..|...|.....:..:|:|| |.:   |
Human   348 -------------------MLIQDDENN------SEMSKDWQKEKMCNKINKVNSEGEFDK---D 384

  Fly   518 TQPVETLSSIETIYCIEVPAATPVAKAATPSETGDKSAP------TAVTPSPAAAQSQADLLLLV 576
            ...:.....:.....::|...:..::..|...:.|.|.|      ..|.|..:|:..::
Human   385 RDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNEGVNPRLSASPPKS------ 443

  Fly   577 ANVYRAKDGADITRFGAPFSMKAPRDCSYQDLQKRMLREMAPLLKPEVFSYATPLAEMFRIRLQD 641
            .|::...         ||...||              :..:|..|.:...|.:.::::|
Human   444 GNLWPGL---------APPHKKA--------------QSASPKRKKQHKKYRSVISDIF------ 479

  Fly   642 PSADPDTYLEQVE-------HPLLTEMIDMALSVLSSEAGPQHIKLLLEWSSPEAHFISKQQDTE 699
                ..|.:..|:       ...|....|::|.:    .|.:.:..|...|.|.:  |.|.....
Human   480 ----DGTIISSVQCLTCDRVSVTLETFQDLSLPI----PGKEDLAKLHSSSHPTS--IVKAGSCG 534

  Fly   700 EAVVEH-------ESVARLSAS-KPS--DTAALTLEQCLEHYTKAETLSAEDAWRCPHCQQYLPV 754
            ||....       |.|.|...| .||  ....:||:.||..:...:.|..::.:.|..|::....
Human   535 EAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNG 599

  Fly   755 VKTLGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFDMSPHLARGVHESASSSLGMG 819
            ||...:.:.|:||.:|.|||| |:..  .:.|::|.|.|||...|:.|.||:
Human   600 VKFCKVQNFPEILCIHLKRFR-HELM--FSTKISTHVSFPLEGLDLQPFLAK------------- 648

  Fly   820 TGIGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTRYDLYAVCYHQGDTLETGHYTAACKNPYD 884
                                ||         .|:...|||.:|..|.| |..:|||.|.|:|..:
Human   649 --------------------DS---------PAQIVTYDLLSVICHHG-TASSGHYIAYCRNNLN 683

  Fly   885 RQWYKFDDQRVSKVPEDDIEQDIINNEAYMLFYQRRSVDA 924
            ..||:||||.|::|.|..::    |.|||:|||::.|.:|
Human   684 NLWYEFDDQSVTEVSESTVQ----NAEAYVLFYRKSSEEA 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	42/121 (35%)
		Peptidase_C19	266..>461	CDD:271592	52/198 (26%)
		Peptidase_C19R	<713..918	CDD:239139	62/207 (30%)
USP33	NP_055832.3	zf-UBP	61..121	CDD:280334
		UCH	184..712	CDD:278850	154/680 (23%)
		Peptidase_C19	186..>288	CDD:271592	41/130 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..357		11/88 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..469		13/78 (17%)
		Peptidase_C19R	473..713	CDD:239139	79/305 (26%)
		DUSP	734..803	CDD:299905
		DUSP	840..924	CDD:197831
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900