DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp15-31 and H34C03.2

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_001293696.1	Gene:	H34C03.2 / 177437	WormBaseID:	WBGene00019259	Length:	980	Species:	Caenorhabditis elegans

Alignment Length:	935	Identity:	215/935 - (22%)
Similarity:	354/935 - (37%)	Gaps:	258/935 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 SLSSY-------------EAPFISSTNNNTTTASNGNNNNSSSSNINSKRTRALRRSSFRKFLNR 179
            |:.||             :..|.....:.|..:..|..::||.|..:.:....|.:.      ||
Worm   206 SIDSYFDTVQKVVVDVEEDGEFFIKGKSATPKSLFGTQSSSSDSEDDVENVVRLPKP------NR 264

  Fly   180 IAQHLSSTVNVVSEEKHSP--ANRIAF---------------IEIVPFYTGCWRRKEANKHGQPS 227
            ..|..:|||:..|.:...|  |..::|               .|.|.|..|.|..:      .||
Worm   265 HRQFSTSTVSSTSSKLLLPLWAVWLSFREAWWGFSQLWPDTIREAVAFLFGWWILR------PPS 323

  Fly   228 VSGSSSGGGGGAGGPGGGERVPPIGGYQWPADQ-------TPGVMGLKNHGNTCFMNAVLQCLSH 285
            .  ||..||.|..           ..|..|:..       |||..||.|.||||||.:..||||:
Worm   324 Y--SSRHGGNGIS-----------NSYNSPSPSTGVVTRTTPGACGLSNLGNTCFMASAFQCLSN 375

  Fly   286 TDILAEYFVLDQYKADLKRRNKINSRKFGTKGELTEQLANVLKALWTCKNESDHSTSFKAVVDRY 350
            ...|.|||:.:.|:.|:...|.:     ||.|.|...:..::|.:|:....|.:...||:::.::
Worm   376 MPPLREYFLANTYQNDINEDNPL-----GTHGHLAMAVGELMKGMWSGDYASINPRKFKSIIGQF 435

  Fly   351 GTQFRSSTQHDAQEFLFWLLDKVHEDLNTASKRRYKSLKNSYGRSDEV-IAAETLANHIRCNNSF 414
            ..:|...:|.||.|.:.::||.:|||||...|:.|....:...:..|. .||::...:...|:|.
Worm   436 APRFNGYSQQDAHELMAYVLDGLHEDLNRIKKKPYIEDSDEDAKLPEAEYAAKSWEVYKMRNDSI 500

  Fly   415 VQAVFQAQFRSSLTCPRCEKQSNTFDPFHCISVQLP---QLTQQTIFVTVVYMTR---------- 466
            :......|.:|:|.||.|||.|..||||..:|:.||   |:.:||  |.|:::||
Worm   501 IVDTLHGQLKSTLICPVCEKISIKFDPFGYLSLPLPPKEQIVKQT--VIVMFLTRKWAKFSLGIT 563

  Fly   467 ----------------------------LPRQ-------VRMG--LRVPAGSPIVALREQLQADT 494
                                        :|.|       :|.|  :|:|.....||   :::.|.
Worm   564 DTTTVEEAERLMLDKLQPEQQHHFVFFHVPSQYHDDITMMRPGDRVRMPGREVYVA---EVEHDL 625

  Fly   495 GIEGSRMVLVDLNAEGFTRVFYDTQPVETLSSIETIYCIEVPAATPVAKAATPSETGDKSAPTAV 559
            .::|:|:.           |.|:...:...:|:..||  .:|...|:.:..........:....:
Worm   626 QVKGTRLF-----------VAYNRIKLVRSASLPMIY--SLPTGYPLTRGFLNDHVFSTTKHFFI 677

  Fly   560 TPSPAAAQSQADLLLLVANVYRAKDGADITRFGAPFSMKAPRDCSYQDLQKRMLREMAPLLKPEV 624
            .|...|.....:     :|...:..|::......|:.:                     .:.|..
Worm   678 NPKAVAELGGGN-----SNDDDSMSGSNSADEREPYKL---------------------FVGPPG 716

  Fly   625 FSYATPLAEMFRIRLQDPSADPDTYLEQVEHPLLTEMIDMALSVLSSEAGPQHIKLLLEWSSPEA 689
            .:.:.|:         .|:.||..:.::..|.:.:..                ::::.:|...:
Worm   717 STASLPI---------PPTDDPIPFPDENSHDIYSNF----------------LQIVFQWKDLK- 755

  Fly   690 HFISKQQDTEEAVVEHESVARLSASKPSDTAALTLEQCLEHYTKAETLSAEDAWRCPHCQQYLPV 754
              |..|....| ::|.|...       |....:.|::.|:.:|..|.|..:|:|.||.|:::...
Worm   756 --IFNQYKGNE-LIEREMTV-------STRRKVLLQETLDWFTTKEQLGEQDSWYCPQCKKHERA 810

  Fly   755 VKTLGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFDMSPHLARGVHESASSSLGMG 819
            .|.|.||.||:||::|.|||   |.......|||..|..|:...|::..:|...||.|.
Worm   811 TKQLALWKLPEILILHLKRF---QYTKWSREKLTWEVVIPVRGLDLTDKVANPNHEKAI------ 866

  Fly   820 TGIGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTRYDLYAVCYHQGDTLETGHYTAACKNPYD 884
                                                 |||.||..|.| :|..|||||...|..:
Worm   867 -------------------------------------YDLIAVSRHYG-SLSGGHYTAIGYNDRE 893

  Fly   885 RQWYKFDDQRVSKV--PEDDIEQDIINNEAYMLFYQRRSVDAG----ECSGSSSNSGDHWVSRIA 943
            ::|:.|:|...:..  |.:..|    :::.|:|.|:||.:|:.    |.|..|.:.........|
Worm   894 QKWFDFNDSSANPTYPPAEPYE----SSDPYILVYRRRKLDSNGKPIEPSAVSESLHSRPKRGAA 954

  Fly   944 PASSSSASSTSGKEREPVKLEENTE 968
            |..||:.||.|....:   ::||.|
Worm   955 PTISSATSSASSSRHQ---VDENME 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	43/120 (36%)
		Peptidase_C19	266..>461	CDD:271592	68/198 (34%)
		Peptidase_C19R	<713..918	CDD:239139	55/206 (27%)
H34C03.2	NP_001293696.1	DUSP	51..135	CDD:197831
		Peptidase_C19	356..>583	CDD:271592	71/233 (30%)
		Peptidase_C19	<777..925	CDD:271592	54/198 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	222	1.000	Inparanoid score	I2273
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	1	1.000	-	-		FOG0000596
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.870