DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp15-31 and Usp33

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_573510.2	Gene:	Usp33 / 170822	MGIID:	2159711	Length:	909	Species:	Mus musculus

Alignment Length:	693	Identity:	166/693 - (23%)
Similarity:	263/693 - (37%)	Gaps:	189/693 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 GVMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLKRRNKINSRKFGTKGELTEQLANVL 327
            |:.||||.||||:|||.||.||:...|.::| ||  ...|.|.:|        |..:.:....::
Mouse   152 GLTGLKNIGNTCYMNAALQALSNCPPLTQFF-LD--CGGLARTDK--------KPAICKSYLKLM 205

  Fly   328 KALWTCKNESDHSTSFKAVV--------DRYGTQFRSSTQHDAQEFLFWLLDKVHEDLNTASKRR 384
            ..||       |.:...:||        ......||..:|.||||||..|:|.:||:|    |.:
Mouse   206 TELW-------HKSRPGSVVPANLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEEL----KEQ 259

  Fly   385 YKSLKNSYG--RSDEVIAAETLANHIRCNNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCISV 447
            ...::....  .|:|.:..|...:.:             .|:|..:|...||..|...     |.
Mouse   260 VMEMEEEPQTLTSEETVEEEKSQSDV-------------DFQSCESCSSSEKAENESG-----SK 306

  Fly   448 QLPQLTQQTIFVTV----VYMTRLPRQVRMGLRVPAGSPIVALREQLQADTGIEGSRMVLVDLNA 508
            ..|:.:.:|..:..    :.|.:..::.::..::...:..|.|.:  ..||..|     .||||:
Mouse   307 GFPEDSNETTMLIQDEDDLEMAKDWQKEKVCNKINKANADVELDK--DRDTVCE-----TVDLNS 364

  Fly   509 EGFTRVFYDTQPVET-----LSSIETIYCIEVPAATPVAKAATPSETGDKSAPTAVTPSPAAAQS 568
            :...:|....:..|:     |:.:.|...:....:.....:|:|.:.|  |....::|....|||
Mouse   365 QETVKVQIHGRASESITDVHLNDLATSQILPSNESVSPRLSASPPKLG--SLWPGLSPPHKKAQS 427

  Fly   569 QADLLLLVANVYRA--KDGADITRFGAPFSMKAPRDC----SYQDLQKRMLREMAPLLKPEVFSY 627
            .:.........||:  .|..|.|...:...:...|..    ::|||.
Mouse   428 TSAKRKKQHKKYRSVISDIFDGTVISSVQCLTCDRVSITLETFQDLS------------------ 474

  Fly   628 ATPLAEMFRIRLQDPSADPDTYLEQVEHPLLTEMIDMALSVLSSEAGPQHIKLLLEWSSPE---A 689
                       |..|..:....|....||.:         |.:...|        |..:|:   |
Mouse   475 -----------LPIPGKEDLAKLHSSSHPTI---------VKAGSCG--------EAYAPQGWIA 511

  Fly   690 HFISKQQDTEEAVVEHESVARLSAS-KPS--DTAALTLEQCLEHYTKAETLSAEDAWRCPHCQQY 751
            .|:             |.|.|...| .||  ....:||:.||..:...:.|..::.:.|..|::.
Mouse   512 FFM-------------EYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKL 563

  Fly   752 LPVVKTLGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFDMSPHLARGVHESASSSL 816
            ...||...:...|:||.:|.|||| |:..  .:.|::|.|.|||...|:.|.||:
Mouse   564 RNGVKFCKVQKFPEILCIHLKRFR-HELM--FSTKISTHVSFPLEGLDLQPFLAK---------- 615

  Fly   817 GMGTGIGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTRYDLYAVCYHQGDTLETGHYTAACKN 881
                                   ||         .|:...|||.:|..|.| |..:|||.|.|:|
Mouse   616 -----------------------DS---------PAQIVTYDLLSVICHHG-TASSGHYIAYCRN 647

  Fly   882 PYDRQWYKFDDQRVSKVPEDDIEQDIINNEAYMLFYQRRSVDA 924
            ..:..||:||||.|::|.|..::    |.|||:|||::.|.:|
Mouse   648 NLNNLWYEFDDQSVTEVSESTVQ----NAEAYVLFYRKSSEEA 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	43/127 (34%)
		Peptidase_C19	266..>461	CDD:271592	55/204 (27%)
		Peptidase_C19R	<713..918	CDD:239139	62/207 (30%)
Usp33	NP_573510.2	zf-UBP	30..90	CDD:366940
		UCH	154..679	CDD:366104	161/682 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..315		11/71 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..436		8/40 (20%)
		DUSP	701..770	CDD:386277
		DUSP	807..891	CDD:197831
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810