Protein Alignment Usp15-31 and USP43

DIOPT Version :10

• Sequence 1: NP_611959.2
• Gene: Usp15-31 / 37954
• FlyBaseID: FBgn0050421
• Length: 1272
• Species: Drosophila melanogaster
• Sequence 2: NP_694942.3
• Gene: USP43 / 124739
• HGNCID: 20072
• Length: 1123
• Species: Homo sapiens
• Alignment Length: 1121
• Identity: 344/1121 - (30%)
• Similarity: 502/1121 - (44%)
• Gaps: 227/1121 - (20%)

  Fly   166 RALRRSSFRKFLNRIAQHLSSTVNVVSEEKHSPANRIAFIEIVPFYTGCWRRKEANKHGQPS-VS 229
            |..||.|.|:..:|....|.|.    |....||                       ...||. ..
Human    17 RPRRRRSLRRLFSRFLLALGSR----SRPGDSP-----------------------PRPQPGHCD 54

  Fly   230 GSSSGGGGGAGGP-------GGGERVP-PIGGYQWPAD---QTPGVMGLKNHGNTCFMNAVLQCL 283
            |...||...|.||       .|.||.| |....|.||.   :.||..||||||||||||||:|||
Human    55 GDGEGGFACAPGPVPAAPGSPGEERPPGPQPQLQLPAGDGARPPGAQGLKNHGNTCFMNAVVQCL 119

  Fly   284 SHTDILAEYFVLDQYKADLKRRNKINSRKFGTKGELTEQLANVLKALWTCKNESDHSTSFKAVVD 348
            |:||:|||:..|.:|:|...|            .|:|||||.:::||||.:.....|..||..|.
Human   120 SNTDLLAEFLALGRYRAAPGR------------AEVTEQLAALVRALWTREYTPQLSAEFKNAVS 172

  Fly   349 RYGTQFRSSTQHDAQEFLFWLLDKVHEDLNTASKRRYKSLKNSYGRSDEVIAAETLANHIRC--- 410
            :||:||:.::||||.|||.||||:|||||..:|:          |...|.:..|.......|
Human   173 KYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSR----------GPVSEKLPPEATKTSENCLSP 227

  Fly   411 ------NNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCISVQLPQLTQQTIFVTVVYMTRLPR 469
                  ..||||:.||||:|||||||.|.|||||||||.|:|:.:|....:.:.||:|:.::..|
Human   228 SAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLRQTRFLSVTLVFPSKSQR 292

  Fly   470 QVRMGLRVPAGSPIVALREQLQADTGIEGSRMVLVDLNAEGFTRVFYDTQPVETLSSIETIYCIE 534
            .:|:||.||..|.:.|||:.:..:.|:....::||:|...||.|.|:|.:.:.|::..:.:|..:
Human   293 FLRVGLAVPILSTVAALRKMVAEEGGVPADEVILVELYPSGFQRSFFDEEDLNTIAEGDNVYAFQ 357

  Fly   535 VPAATPVAKAATPSETGDKSAPTAVTPSPAAA-----------QSQADLLLLVANVYRAKDGADI 588
            ||        .:||:....:.|..::.||..|           .|::.:|:|..|:  ...|...
Human   358 VP--------PSPSQGTLSAHPLGLSASPRLAAREGQRFSLSLHSESKVLILFCNL--VGSGQQA 412

  Fly   589 TRFGAPFSMKAPRDCSYQDLQKRMLREMAPLLKPEVFSYATPLAEMFRIRLQDPSADPDTYLEQV 653
            :|||.||.::..|..|:..||:.:|.::..|:|.|  :....|..:|.||:...|........:.
Human   413 SRFGPPFLIREDRAVSWAQLQQSILSKVRHLMKSE--APVQNLGSLFSIRVVGLSVACSYLSPKD 475

  Fly   654 EHPLLTEMIDMALSVLSSEAGPQHIKLLLEWSS--PEAHFISKQQDTEEAVVEHESVARLSASKP 716
            ..||....:|..|. |....||.|:||.:||.|  .|..|.|.|   ||...:.:||.:...:..
Human   476 SRPLCHWAVDRVLH-LRRPGGPPHVKLAVEWDSSVKERLFGSLQ---EERAQDADSVWQQQQAHQ 536

  Fly   717 SDTAALTLEQCLEHYTKAETLSAEDAWRCPHCQQYLPVVKTLGLWSLPDILVVHFKRFRQHQSKG 781
            ..:.  ||::|.:.|||.|.|:.:|||:|||||.....:..|.||:|||||::|.|||.|   .|
Human   537 QHSC--TLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQ---VG 596

  Fly   782 PQAAKLTTMVKFPLTAFDMSPHLARGVHESASSSLGMGTGIGLGLGLGSNPWKKARSVDSRSSTL 846
            .:..||:|:|||||:..:|:||:|:   .|.|...|:|            ||...:..|...::.
Human   597 ERRNKLSTLVKFPLSGLNMAPHVAQ---RSTSPEAGLG------------PWPSWKQPDCLPTSY 646

  Fly   847 NSRCDAKDTRYDLYAVCYHQGDTLETGHYTAACKNPYDRQWYKFDDQRVSKVPEDDIEQDIINNE 911
                 ..|..|||||||.|.|: |:.|||||.|:|..|.|||.:||..|..:.||::.    ...
Human   647 -----PLDFLYDLYAVCNHHGN-LQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVN----TRG 701

  Fly   912 AYMLFYQRR-SVDAGECSGS-----SSNSGDHWVSRIAPASSSSASSTSGKEREPV-KLEENTES 969
            ||:||||:| |:.....|.|     ||:..|||:.|:...:.|:..|.......|. .|.:..:|
Human   702 AYILFYQKRNSIPPWSASSSMRGSTSSSLSDHWLLRLGSHAGSTRGSLLSWSSAPCPSLPQVPDS 766

  Fly   970 PAAVEV---TEKAQSKPVDIVCQDKAKGTADGPDADQEQTTVPHDLQIEELAFADADVDTSLGET 1031
            |.....   .||...:|..:|...|.:..:         ...|...:.::..|          :|
Human   767 PIFTNSLCNQEKGGLEPRRLVRGVKGRSIS---------MKAPTTSRAKQGPF----------KT 812

  Fly  1032 IKAEVNLAAKDEPKKVEVEEATPIFAMDEDGSEARQEKKEECVKK-------EDELSEAPDVS-E 1088
            :....:..:|::|....||      .::...|..|.....:.:..       |||.|.:|..: .
Human   813 MPLRWSFGSKEKPPGASVE------LVEYLESRRRPRSTSQSIVSLLTGTAGEDEKSASPRSNVA 871

  Fly  1089 LTAESKTNG------------------HVSSSSSSSSSESSLSSRSS-------PRSLSTSVTAA 1128
            |.|.|:..|                  |..:..:|....::...:.:       ||.....:|..
Human   872 LPANSEDGGRAIERGPAGVPCPSAQPNHCLAPGNSDGPNTARKLKENAGQDIKLPRKFDLPLTVM 936

  Fly  1129 STL----------QSKFN-------GHMSAAPALFNG-NGN-------TSQLSSSLQ----LSRH 1164
            .::          |...|       |..|:.|:.:.| :||       ||:|...||    |.|.
Human   937 PSVEHEKPARPEGQKAMNWKESFQMGSKSSPPSPYMGFSGNSKDSRRGTSELDRPLQGTLTLLRS 1001

  Fly  1165 VLHNHQ-WHGSRSSVS 1179
            |....: ....|:.||
Human  1002 VFRKKENRRNERAEVS 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	UBP12	<255..921	CDD:227847	258/691 (37%)
USP43	NP_694942.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..102		29/111 (26%)
		UBP12	<96..711	CDD:227847	254/682 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..221		4/28 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	795..826		4/49 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	854..886		9/31 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	959..1049		17/59 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1068..1099