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Protein Alignment Usp15-31 and USP19

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	XP_005264880.1	Gene:	USP19 / 10869	HGNCID:	12617	Length:	1423	Species:	Homo sapiens

Alignment Length:	846	Identity:	233/846 - (27%)
Similarity:	338/846 - (39%)	Gaps:	227/846 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 PGVMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLKRRNKINSRKFGTKGELTEQLANV 326
            ||..||.|.|||||||:|:|.||:|..|.::|....::|::...|.:     ||.|.|....|.:
Human   599 PGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPL-----GTGGRLAIGFAVL 658

  Fly   327 LKALWTCKNESDHSTSFKAVVDRYGTQFRSSTQHDAQEFLFWLLDKVHEDLNTASKRRYKSLKNS 391
            |:|||...:.:...:..||:|....:||....|||||||:.:|||.:|||||....:.|....:|
Human   659 LRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDS 723

  Fly   392 YGRSDEVIAAETLANHIRCNNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCISVQLPQLTQQT 456
            .||.|||:|.|....|...|:||:..:||.|::|.|.||.|.|.|.|||||..:.|.|||  :|.
Human   724 DGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQ--KQK 786

  Fly   457 IFVTVVYMTRLPRQVRMGLRVPA---GSPIVALREQLQADTGIEGSRMVLVDLNAEGFTRVFYDT 518
            : :.|.|..|.|....:...|..   .|....:.:.|.....::...:.|.::....|.|||..:
Human   787 V-LPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPS 850

  Fly   519 QPVETLSSIETIYCIEVPAATPVAKAATPSETGDKSAPTAVTPSPAAA-----QSQADLLLLVAN 578
            ..::|:|..:|:.|.|:.::....:.....|...:....:|..|..||     ||:.:.|.....
Human   851 HSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCAACQRKQQSEDEKLKRCTR 915

  Fly   579 VYRA------------KDGADITR---FGAPFSMKAPRDCSYQDLQKRMLREMAPLLKPEVFSYA 628
            .||.            .|...:.|   .|.||.:..|       ..:.....:|.||:    .||
Human   916 CYRVGYCNQLCQKTHWPDHKGLCRPENIGYPFLVSVP-------ASRLTYARLAQLLE----GYA 969

  Fly   629 TPLAEMF-------RIRLQDPSADPDTYL------------EQVEHPLLTEMIDMA--------- 665
            .....:|       |:.|:..|....|.|            :.::.|.|..:..||
Human   970 RYSVSVFQPPFQPGRMALESQSPGCTTLLSTGSLEAGDSERDPIQPPELQLVTPMAEGDTGLPRV 1034

  Fly   666 -----------LSVLSSE---AGPQHIKLL---LEWSSPEAHFISKQQDTEEAVVEH-------- 705
                       .|.:|||   :||..:..|   ...|.||| .:...|...||:..|
Human  1035 WAAPDRGPVPSTSGISSEMLASGPIEVGSLPAGERVSRPEA-AVPGYQHPSEAMNAHTPQFFIYK 1098

  Fly   706 -ESVAR----------------------------------LSASKPSDTAA-------------L 722
             :|..|                                  |.|||..:.|.             .
Human  1099 IDSSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHF 1163

  Fly   723 TLEQCLEHYTKAETLSAEDAWRCPHCQQYLPVVKTLGLWSLPDILVVHFKRF-------RQHQSK 780
            ||:|||..:|:.|.|:.|:||.||.|:|:....|.|.||.||::|:|..|||       |.
Human  1164 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRD---- 1224

  Fly   781 GPQAAKLTTMVKFPLTAFDMSPHLARGVHESASSSLGMGTGIGLGLGLGSNPWKKARSVDSRSST 845
                 |:..:|:||:...|:|...                 ||          :|...:.|
Human  1225 -----KINDLVEFPVRNLDLSKFC-----------------IG----------QKEEQLPS---- 1253

  Fly   846 LNSRCDAKDTRYDLYAVCYHQGDTLETGHYTAACKNPYDRQ-------WYKFDDQRVSKVPEDDI 903
                       ||||||..|.|..: .|||||..:.|.||.       |..|||..|:.|.
Human  1254 -----------YDLYAVINHYGGMI-GGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVD---- 1302

  Fly   904 EQDIINNEAYMLFYQRRS--VDAGECSGSSSNSGDHWVSRIAPASSSSASSTS------GKEREP 960
            |..::...||:|||:||:  |:....:|.|.:..|     :.||:.::||..|      ..|.||
Human  1303 ESQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPD-----LGPAAEAAASQASRIWQELEAEEEP 1362

  Fly   961 V 961
            |
Human  1363 V 1363

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.