DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp15-31 and USP20

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_001008563.2	Gene:	USP20 / 10868	HGNCID:	12619	Length:	914	Species:	Homo sapiens

Alignment Length:	710	Identity:	165/710 - (23%)
Similarity:	262/710 - (36%)	Gaps:	211/710 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 GVMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLKRRNKINSRKFGTKGELTEQLANVL 327
            |:.|:||.||:|:|||.||.||:...|.::|:   ....|.|.:|        |..|.:....::
Human   143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFL---ECGGLVRTDK--------KPALCKSYQKLV 196

  Fly   328 KALWTCKNES-DHSTSFKAVVDRYGTQFRSSTQHDAQEFLFWLLDKVHEDLN---TASKRRYKSL 388
            ..:|..|..| ...||....:......||...|.|.||||..|:|::||:|.   .|:....::.
Human   197 SEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPVVATVALTEAR 261

  Fly   389 KNSYGRSDEVIAAETLANH---IRCNNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCISVQLP 450
            .:....:||....:...:.   :.|::|..:.....|.|..     ...|:.|       .:.:|
Human   262 DSDSSDTDEKREGDRSPSEDEFLSCDSSSDRGEGDGQGRGG-----GSSQAET-------ELLIP 314

  Fly   451 QLTQQTIFVTVVYMTRLPRQVRMGLRVPAGSPIVALREQLQADTGIEGSRMVLVDLNAEGFTRVF 515
            ....:.|          ..:.||..|..:........||:..|..::.:...|.|..||
Human   315 DEAGRAI----------SEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMAALDDQPAE------ 363

  Fly   516 YDTQPVETLSSIETIYCIEVPAATP----------VAKAATP----------SETGDKSAPTAVT 560
              .||....||        .|..||          .::..:|          |.:..:::|..:.
Human   364 --AQPPSPRSS--------SPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSPPRASPVRMA 418

  Fly   561 PSPAAAQSQADLLLLVANVYRAKDG------ADITRFGAPFSMKAPRDC--------SYQDLQKR 611
            ||....::|    :|.|...|.|:.      :||.. |:..|:.....|        ::|||.
Human   419 PSYVLKKAQ----VLSAGSRRRKEQRYRSVISDIFD-GSILSLVQCLTCDRVSTTVETFQDLS-- 476

  Fly   612 MLREMAPLLKPEVFSYATPLAEMFRIRLQDPSADP----DTYLEQVEHPLLTEMIDMALSVLSSE 672
                 .|:...|      .||::.....|:..|.|    |:|..|
Human   477 -----LPIPGKE------DLAKLHSAIYQNVPAKPGACGDSYAAQ-------------------- 510

  Fly   673 AGPQHIKLLLEWSSPEAHFISKQQDTEEAVVEHESVARLSAS-KPS--DTAALTLEQCLEHYTKA 734
                      .|.:              .:||:  :.|...| .||  ....:|||.||..:..|
Human   511 ----------GWLA--------------FIVEY--IRRFVVSCTPSWFWGPVVTLEDCLAAFFAA 549

  Fly   735 ETLSAEDAWRCPHCQQYLPVVKTLGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFD 799
            :.|..::.:.|..|::....||...:..||:||.:|.|||| |:..  .:.|:.:.|.|||...|
Human   550 DELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFR-HEVM--YSFKINSHVSFPLEGLD 611

  Fly   800 MSPHLARGVHESASSSLGMGTGIGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTRYDLYAVCY 864
            :.|.||:                                          .|.::.|.|||.:|..
Human   612 LRPFLAK------------------------------------------ECTSQITTYDLLSVIC 634

  Fly   865 HQGDTLETGHYTAACKNPYDRQWYKFDDQRVSKVPEDDIEQDIINNEAYMLFYQRRSVDA 924
            |.| |..:|||.|.|:|..:.|||:||||.|::|.|..::    |.|.|:|||::.|.:|
Human   635 HHG-TAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQ----NAEGYVLFYRKSSEEA 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	40/123 (33%)
		Peptidase_C19	266..>461	CDD:271592	49/201 (24%)
		Peptidase_C19R	<713..918	CDD:239139	63/207 (30%)
USP20	NP_001008563.2	zf-UBP	30..90	CDD:280334
		UCH	144..682	CDD:278850	160/700 (23%)
		Peptidase_C19	144..>291	CDD:271592	43/157 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..347		15/111 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..415		11/70 (16%)
		Peptidase_C19R	443..683	CDD:239139	85/349 (24%)
		DUSP	702..785	CDD:197831
		DUSP	810..895	CDD:197831
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810