Protein Alignment Usp15-31 and USP16

DIOPT Version :9

• Sequence 1: NP_611959.2
• Gene: Usp15-31 / 37954
• FlyBaseID: FBgn0050421
• Length: 1272
• Species: Drosophila melanogaster
• Sequence 2: NP_001027582.1
• Gene: USP16 / 10600
• HGNCID: 12614
• Length: 823
• Species: Homo sapiens
• Alignment Length: 770
• Identity: 164/770 - (21%)
• Similarity: 252/770 - (32%)
• Gaps: 232/770 - (30%)

  Fly   249 PPIGGYQWPADQTPGVMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKAD------------ 301
            ||:..   |...|  |.||.|.|||||.|||:|.||.|.:|.|  :|.:.|..
Human   185 PPMNS---PCQIT--VKGLSNLGNTCFFNAVMQNLSQTPVLRE--LLKEVKMSGTIVKIEPPDLA 242

  Fly   302 LKRRNKINSRKFGTKGELTEQLANVLKALWTCKNESDHSTSFKAVVDRYGTQFRSSTQHDAQEFL 366
            |....:||   ....|.||..::..|..:...|..........:.|.:...:|:...|.|:||.|
Human   243 LTEPLEIN---LEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELL 304

  Fly   367 FWLLDKVHEDLNTASKRRYKSLKNSYGRSDEVIAAETLANHI------RCNNSFVQAVFQAQFRS 425
            .:|||.:..:   ..:|..|.:..::|.|.|.: .|.|.|.:      :...|||..:|..:..|
Human   305 RYLLDGMRAE---EHQRVSKGILKAFGNSTEKL-DEELKNKVKDYEKKKSMPSFVDRIFGGELTS 365

  Fly   426 SLTCPRCEKQSNTFDPFHCISVQLPQLTQQTIFVTVVYMTRLPRQVRMGLRVPAGSPIVALREQL 490
            .:.|.:|...|...:.|  :.:.||.|..|:
Human   366 MIMCDQCRTVSLVHESF--LDLSLPVLDDQS---------------------------------- 394

  Fly   491 QADTGIEGSRMVLVDLNAEGFTRVFYDTQPVETLSSIETIYCIEVPAATPVAKAATPSETGDKSA 555
                   |.:.|    |.:...:...|.............|..|        ::..||.|.....
Human   395 -------GKKSV----NDKNLKKTVEDEDQDSEEEKDNDSYIKE--------RSDIPSGTSKHLQ 440

  Fly   556 PTAVTPSPAAAQSQADLLLLVANVYRAKDGADITRFGAPFSMKAPRDCSYQDLQKRMLREMAPLL 620
            ..|...:...|::|.....:...|....|...|..         |.|..|:       .||:  |
Human   441 KKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDH---------PEDSEYE-------AEMS--L 487

  Fly   621 KPEV------FSYATPLAEMFRIRLQDPSADPDTYLEQVEHPLLTEMIDMA-------LSVL-SS 671
            :.||      .|....:.:.:.:..:|.:..........::...||.:||.       |.|| ||
Human   488 QGEVNIKSNHISQEGVMHKEYCVNQKDLNGQAKMIESVTDNQKSTEEVDMKNINMDNDLEVLTSS 552

  Fly   672 EAGPQHIKLLLEWSS-------------------PEAHFISKQQDTE-------EAVVEHESVA- 709
            .....:...|.|.|:                   |:...|....|:.       |.|.|....|
Human   553 PTRNLNGAYLTEGSNGEVDISNGFKNLNLNAALHPDEINIEILNDSHTPGTKVYEVVNEDPETAF 617

  Fly   710 -RLSASKPSDTAALTLEQCLEHYTKAETLSAEDAWRCPHCQQ-----------------YLPVVK 756
             .|:..:..:|...:::.||..:|:.|.|...:...|..|.:                 |....|
Human   618 CTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKK 682

  Fly   757 TLGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFDMSPHLARGVHESASSSLGMGTG 821
            .:.:...|.:|.:|.|||:|   .|....|:...:||| ...|::|...
Human   683 QMLISLAPPVLTLHLKRFQQ---AGFNLRKVNKHIKFP-EILDLAPFCT---------------- 727

  Fly   822 IGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDTRYDLYAVCYHQGDTLETGHYTAACKN----- 881
                        .|.::|...    |:|     ..|.||.|..|.| |:.:|||||..|.
Human   728 ------------LKCKNVAEE----NTR-----VLYSLYGVVEHSG-TMRSGHYTAYAKARTANS 770

  Fly   882 -----------PYD------RQWYKFDDQRVSKVPEDDIEQDIINNEAYMLFYQR 919
                       |.|      .||:...|..|..||    ...::|::||:|||:|
Human   771 HLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVP----TTKVLNSQAYLLFYER 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	38/132 (29%)
		Peptidase_C19	266..>461	CDD:271592	58/212 (27%)
		Peptidase_C19R	<713..918	CDD:239139	54/243 (22%)
USP16	NP_001027582.1	zf-UBP	48..123	CDD:280334
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..189		2/3 (67%)
		Peptidase_C19K	197..>402	CDD:239132	61/260 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	394..460		12/118 (10%)
		Peptidase_C19K	<623..820	CDD:239132	54/242 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900