DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp15-31 and usp4

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	XP_002936515.1	Gene:	usp4 / 100491110	XenbaseID:	XB-GENE-988404	Length:	975	Species:	Xenopus tropicalis

Alignment Length:	1134	Identity:	290/1134 - (25%)
Similarity:	428/1134 - (37%)	Gaps:	340/1134 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 AAGVT-TTLPA-TKTTTTAADTST---------TNAAKKIRRTFSMPRNPFRWTRKFKTAVAV-- 84
            |.|.| |..|| |....|:|||.|         .:|.||....:.:..   ||.:::|..|..
Frog    14 AQGSTRTPSPAPTPEPGTSADTETQKAELGDLLKSALKKGDEWYLIDS---RWFKQWKKYVGFDA 75

  Fly    85 -----------------TSSAGAENDNESGKNN----------------------GARERRGSHT 110
                             .|...|::|.:..|.:                      |:.|  |.|.
Frog    76 WDMYNVGESSLYPGPVDNSGLFADHDTQVLKEHLIDELDYVLVPTEAWKKLMNWYGSVE--GQHP 138

  Fly   111 AISSCVGGGRGRSGSIVSLSSYEAPFISSTNNNTTTASNGNNNNSSSS---------NINS-KRT 165
            .:...|..|.......|.:...|......::.....|.:.:..::..:         ||:: |.|
Frog   139 IVRKVVEHGLFVKNCKVEVYLIELKLCDDSDPENVIARHFSKADTIDTIEKEMRNIFNISADKET 203

  Fly   166 RALRRSSFRKFLNRIAQHLS---STVN---------VVSEEKHSPANRIAFIEIVPFYTGCWRRK 218
            |.     :.:::....:.|:   |||.         :|.|::::              .|.|.|:
Frog   204 RL-----WNRYMTNTYEQLTKKESTVQDAGLYQGQMIVIEQRNA--------------DGTWPRQ 249

  Fly   219 EANK-----------HGQPSVSG-----------SSSGGGGGAGGPGGGERVPPIGGYQW--PAD 259
            ...|           .|:||.|.           ||:.....:.|...|........|.:  |:.
Frog   250 PQTKSSTATSRNFATSGKPSTSSYSTSSSMTNGDSSTYSQNNSSGLNKGGYTSSYSSYSYREPSS 314

  Fly   260 QTPGVMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLKRRNKINSRKFGTKGELTEQLA 324
            | ||:.||.|.|||||||:.|||||:|..|..|||.|:||.::.|.|.:     |.|||:....|
Frog   315 Q-PGLCGLSNLGNTCFMNSALQCLSNTPPLTRYFVTDEYKKEINRENPL-----GMKGEIAVAYA 373

  Fly   325 NVLKALWTCKNESDHSTSFKAVVDRYGTQFRSSTQHDAQEFLFWLLDKVHEDLNTASKRRYKSLK 389
            .:::.:|:.::.......||..|.|:..||....|.|:||.|.:|||.:|||||...|:.|..||
Frog   374 ELIRQIWSGEHSYVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELK 438

  Fly   390 NSYGRSDEVIAAETLANHIRCNNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCISVQLPQLTQ 454
            ::.||.|.|:|||...||:|.|||.:..:|...|:|:|.||.|.|.|.|||||..:::.||....
Frog   439 DANGRPDSVVAAEAWENHLRRNNSIIVDIFHGLFKSTLVCPECSKVSVTFDPFCYLTLPLPMKKD 503

  Fly   455 QTIFVTVVYMTR-----LPRQVRMGLRVPAGSPIVALREQLQADTGIEGSRMVLVDLNAEGFTRV 514
            :|:   .|:..|     .|:|.|  :.||....:..|...|...:.:....||:.|:....|.::
Frog   504 RTM---EVFFVRSDPHCKPKQYR--VTVPKMGVVSDLCSALSKLSEVPAENMVVTDVYNHRFHKI 563

  Fly   515 FYDTQPVETLSSI---ETIYCIEVPAATPVAKAATPSETGDKSAPTAVTPSPAAAQSQADL-LLL 575
            |   |..|.||.|   :.|:..||                          .|..|:....| :..
Frog   564 F---QMDEMLSHIMERDDIFVYEV--------------------------KPRKAEEWVTLPICF 599

  Fly   576 VANVYRAKDGADITRFGAPFSMKAPR-----DCSYQDLQKRMLREMA-PLLKPEVFSYATPLA-- 632
            ....||.........||.|..:..|:     |..|:.:.:|:.|.:. |  .||.:|.::..:
Frog   600 RERRYRQATSTGTVLFGQPIMISVPKHNLTLDVLYEIVLERIQRYVKNP--HPESYSCSSTDSGA 662

  Fly   633 ----------EMFRIRLQDPSADPDTYLEQVEHPLLTEMID------------------------ 663
                      ||..   |:..||.....::..:....|.::
Frog   663 CNGSNGIYDDEMDH---QEEDADDQEESQEETNGQSDESVEEENSEGGCSPCNKMPKKALVCRNR 724

  Fly   664 -MALSVLSSEA--------GPQHIKL------LLEWSSPEAHFISKQQDTEEAVVEHESVARLSA 713
             .|.|:::|.|        ...::||      .::|.|.........|:. ||..:|||:.:...
Frog   725 LFAFSLVNSYATADVGSMPAKGYLKLSSFATVAIDWDSESKKLFYDDQEA-EAFDKHESMTQPQK 788

  Fly   714 SKPSDTAALTLEQCLEHYTKAETLSAEDAWRCPHCQQYLPVVKTLGLWSLPDILVVHFKRFRQHQ 778
            .|    ..:.|.:|::.:||.|||...|.|.||||:::....|...|||||.|||||.|||..::
Frog   789 KK----VTVALRECIQLFTKTETLGEHDPWYCPHCKKHQRATKKFDLWSLPKILVVHLKRFSYNR 849

  Fly   779 SKGPQAAKLTTMVKFPLTAFDMSPHLARGVHESASSSLGMGTGIGLGLGLGSNPWKKARSVDSRS 843
            .   ...||..:|:||:...:||..:
Frog   850 F---WRDKLDAVVEFPIRDLNMSDFV--------------------------------------- 872

  Fly   844 STLNSRCD--AKDTRYDLYAVCYHQGDTLETGHYTAACKNPYDRQWYKFDDQRVSKVPEDDIEQD 906
                  ||  |....|||.||..|.|. :..|||||..||....|||.|||..||...||    .
Frog   873 ------CDPQAGPYVYDLVAVSNHYGG-MGGGHYTAYAKNQDKGQWYYFDDSSVSPASED----Q 926

  Fly   907 IINNEAYMLFYQRRSVDAGECSGSSSNSGDHWVSRIAPASSSSASSTSGKEREPVKLEENTESPA 971
            |:...||:|||||:  |..:|..||            ||:|.|                   |||
Frog   927 IVTKAAYVLFYQRQ--DNIDCKNSS------------PAASIS-------------------SPA 958

  Fly   972 AVEVTEKAQSKPVDIVCQDKAKGTADGPD 1000
            |.|..|:              :|..|..|
Frog   959 AEEDLEE--------------RGDCDSMD 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	52/120 (43%)
		Peptidase_C19	266..>461	CDD:271592	84/194 (43%)
		Peptidase_C19R	<713..918	CDD:239139	67/206 (33%)
usp4	XP_002936515.1	UBP12	36..939	CDD:227847	260/1029 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	1	1.000	-	-		FOG0000596
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010