DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp15-31 and usp15

DIOPT Version :9

Sequence 1:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	XP_017209945.1	Gene:	usp15 / 100329380	ZFINID:	ZDB-GENE-100210-1	Length:	852	Species:	Danio rerio

Alignment Length:	982	Identity:	220/982 - (22%)
Similarity:	311/982 - (31%)	Gaps:	369/982 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VTTTLPATKTTTTAADTSTTNA-AKKIRRTFSMP--RNPFRWTRKFKTAV-------AVTSSAG- 89
            ||.|...|.|.|.....|..:: .:::|:.||:|  :....|.|......       :....||
Zfish   199 VTHTHTHTHTHTLFCCVSPADSIEREMRKLFSIPDEKETRLWNRYMSNTFEPLNKPHSTIQDAGL 263

  Fly    90 -------AENDNESGK-NNGARERRGSHTAISSCVGGGRGRSGSIVSLSSYEAPFISSTNNNTTT 146
                   .|..||.|. ..|:...:.|..|:|:                   .|.||       .
Zfish   264 YQGQVLVIEQQNEDGSWPRGSSSLKSSAAALSA-------------------LPKIS-------P 302

  Fly   147 ASNGNNNNSSSSNINSKRTRALRRSSFRKFLNRIAQHLSSTVNVVSEEKHSPANRIAFIEIVPFY 211
            :|...|::||.||.|.|                                 ||.:.::
Zfish   303 SSLSANHSSSFSNRNLK---------------------------------SPYSSVS-------- 326

  Fly   212 TGCWRRKEANKHGQPSVSGSSSGGGGGAGGPGGGERVPPIGGYQWPADQTPGVMGLKNHGNTCFM 276
              |            |...||||                      ..:|..|:.||.|.||||||
Zfish   327 --C------------SPYSSSSG----------------------VCEQRAGLCGLSNLGNTCFM 355

  Fly   277 NAVLQCLSHTDILAEYFVLDQYKADLKRRNKINSRKFGTKGELTEQLANVLKALWTCKNESDHST 341
            |:..||||:...|.::|:.:||:.:|.:.|.:     |..||:....|.::|.||..:.......
Zfish   356 NSATQCLSNVPPLTQFFLTEQYQQELNQDNPL-----GMGGEIARAYAELIKQLWGARCSYITPR 415

  Fly   342 SFKAVVDRYGTQFRSSTQH-----DAQEFLFWLLDKVHEDLNTASKRRYKSLKNSYGRSDEVIAA 401
            .||             .||     .|.....|:.......:.|.|:...:|..:|...|...:
Zfish   416 PFK-------------VQHCGEHISAGHACLWVTHLNQSHIRTHSEHACRSRHSSALSSTPAL-- 465

  Fly   402 ETLANHIRCNNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCISVQLPQLTQQTIFVTVVYMTR 466
              |:.|                                 | |.:|..|           |:::..
Zfish   466 --LSTH---------------------------------P-HSLSASL-----------VLFLCS 483

  Fly   467 LPRQVRMGLRVPAGSPIVALREQLQADTGIEGSRMVLVDLNAEGFTRVFYDTQPVETLSSIETIY 531
                              |.:..:...||.|.:|.:..            ||:..|..||
Zfish   484 ------------------ATQMMMTTPTGPEANRFIRA------------DTKDCEDSSS----- 513

  Fly   532 CIEVPAATPVAKAATPSETGDKSAPTAVTPSPAAAQSQADLLLLVANVYRAKDGADITRFGAPFS 596
                |...|:..:||.....|.|      ||........|.|.:...|....|.:.:.
Zfish   514 ----PKHHPINGSATNGTAEDCS------PSEMETDEPDDELSVEQGVSSESDSSSLA------- 561

  Fly   597 MKAPRDCSYQDLQKRMLREMAPLLKPEVFSYATPLAEMFRIRLQD-PSADPDTYLEQVEHPLLTE 660
                        :::.|.....||:        |...:|.:::.: ...|....|....|
Zfish   562 ------------EEQKLENGPSLLE--------PCRRLFSLQITNMGKTDGGALLTGEPH----- 601

  Fly   661 MIDMALSVLSSEAGPQHIKLLLEWSSPEAHFISKQQDTEEAVVE----HESVARLSASKPSDTAA 721
                |......|.......|.|.| .||    .|:....||.||    |.|:    ..||....:
Zfish   602 ----AQIHFQEERLSDRCYLSLVW-EPE----MKRSFFNEAAVEDFEKHHSM----DYKPQKKMS 653

  Fly   722 LTLEQCLEHYTKAETLSAEDAWRCPHCQQYLPVVKTLGLWSLPDILVVHFKRFRQHQSKGPQAAK 786
            ..|..|::.:|..|.|.|:|.|.||.|:|:....|.|.|||||.:||||.|||...:.   ...|
Zfish   654 CRLRDCIQLFTTKEKLGADDPWYCPSCKQHQQATKQLDLWSLPPVLVVHLKRFSYSRY---MRDK 715

  Fly   787 LTTMVKFPLTAFDMS-----PHLARGVHESASSSLGMGTGIGLGLGLGSNPWKKARSVDSRSSTL 846
            |.|:|:|||...|||     ||                .|:.|
Zfish   716 LDTLVEFPLRDLDMSEFLINPH----------------AGVCL---------------------- 742

  Fly   847 NSRCDAKDTRYDLYAVCYHQGDTLETGHYTAACKNPYDRQWYKFDDQRVSKVPEDDIEQDIINNE 911
                      |||.||..|.|. :..|||||..||..|.|||.|||..||...    |:.|::..
Zfish   743 ----------YDLIAVSNHYGG-MGGGHYTAYAKNVEDGQWYSFDDSSVSPAS----EEQIVSKA 792

  Fly   912 AYMLFYQRRSVDAGECSGSSSNSGDHWVSRIAPASSSSASSTSGKEREPVKLEENTESPAAVEVT 976
            ||:|||||:....|        :|...:.|..||           |:|..:.:|:.|.....|..
Zfish   793 AYVLFYQRQDTVRG--------TGYFALDREPPA-----------EKEEEEEDEDEEDVNDSEQE 838

  Fly   977 EKAQSKP 983
            |..|..|
Zfish   839 EDLQPSP 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	36/125 (29%)
		Peptidase_C19	266..>461	CDD:271592	44/199 (22%)
		Peptidase_C19R	<713..918	CDD:239139	71/209 (34%)
usp15	XP_017209945.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283205at2759
OrthoFinder	1	1.000	-	-		FOG0000596
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010