Protein Alignment Usp15-31 and usp43b

DIOPT Version :10

• Sequence 1: NP_611959.2
• Gene: Usp15-31 / 37954
• FlyBaseID: FBgn0050421
• Length: 1272
• Species: Drosophila melanogaster
• Sequence 2: XP_001920291.2
• Gene: usp43b / 100149276
• ZFINID: ZDB-GENE-120524-2
• Length: 1183
• Species: Danio rerio
• Alignment Length: 1246
• Identity: 382/1246 - (30%)
• Similarity: 561/1246 - (45%)
• Gaps: 245/1246 - (19%)

  Fly   154 NSSSSNINSKRT-RALRRSSFR---KFLNRIAQHLSSTVN--VVSEEKHSPANRIAFIEIVPFYT 212
            |..|.:.::||| :..||.||:   ..::||.:.|.|..:  ..:|...:..:...|.|..| ..
Zfish     9 NKDSGSKSTKRTGKLFRRKSFKSVESLVSRILKSLGSLASGGETAERSDAEDDDGGFGESAP-CA 72

  Fly   213 GCWRRKEANKHGQPSVSGSSSGGGGGAGGPGGGERVPPIGGYQWPADQTPGVMGLKNHGNTCFMN 277
            |...:||.:......|..|||    ........||:..:.|     |:||||:||||||||||||
Zfish    73 GNSVKKEDSSTSSSQVRKSSS----LTSRSSAKERMFSLYG-----DKTPGVLGLKNHGNTCFMN 128

  Fly   278 AVLQCLSHTDILAEYFVLDQYKADLKRRNKI-----NSRKFGTKGELTEQLANVLKALWTCKNES 337
            ||:||||:||:||||..|::||.|: ..|.|     |......|||:||:||.:::||||.:...
Zfish   129 AVVQCLSNTDLLAEYLGLERYKRDV-CHNGINGFIRNGNGQNEKGEVTERLAVLVRALWTFQYTP 192

  Fly   338 DHSTSFKAVVDRYGTQFRSSTQHDAQEFLFWLLDKVHEDL-------NTASKRRYKSLKNSYGRS 395
            ..|..||..|.:||.|||.::||||.|||.||||::|||.       |..:|.:.|..:.    .
Zfish   193 QLSAEFKMTVSKYGAQFRGNSQHDALEFLLWLLDRLHEDSTSVVPNGNNINKSKNKGQEG----G 253

  Fly   396 DEVIAAETLA---NHIRCNNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCISVQLPQLTQQTI 457
            ||...::||:   ......:||||..||||::||||||.|.|||||||||.|||:.:|....:.:
Zfish   254 DEKPGSDTLSPPQTQPGVRHSFVQEHFQAQYKSSLTCPHCLKQSNTFDPFLCISLPIPLRQTRPV 318

  Fly   458 FVTVVYMTRLPRQVRMGLRVPAGSPIVALREQLQADTGIEGSRMVLVDLNAEGFTRVFYDTQPVE 522
            .||:|:.::..|.:|:||.||....:..||..:..:..|...:::|.::...||.|.|:|...:.
Zfish   319 CVTLVFSSKGQRYLRVGLAVPLFGSLACLRRMVADEGKIAPDQVILTEIYTTGFQRSFFDDDDLT 383

  Fly   523 TLSSIETIYCIEVPAATPV------AKA-----ATPSETGDKSAPTAVTPSPAAAQS-----QAD 571
            .::..:.||..:   |:|:      |:.     :.||.....|.|.....:.:.|.|     |.|
Zfish   384 IIAESDIIYAFQ---ASPLYIRGGSARISGFHHSLPSSPYSSSGPEGHRLAASGALSSEFLNQTD 445

  Fly   572 ----LLLLVANVYRAKDGADITRFGAPFSMKAPRDCSYQDLQKRMLREMAPLLKPEVFSYATPLA 632
                :||||.|.  |..|....|||.||.|:..|..|:..||:.:|.::..|:...  |.|....
Zfish   446 GMLKVLLLVCNA--AGAGQQAVRFGPPFLMREDRSVSWDQLQQSILSKLYYLMING--SQAHNFR 506

  Fly   633 EMFRIRLQDPSADPDTYLEQVEHPLLTEMIDMALSVLSSEAGPQHIKLLLEWSS--PEAHFISKQ 695
            .:|:||:...||.......|...||....:|.||.:..| .||.|:||::||..  .:..|.:.|
Zfish   507 VLFKIRVVGGSASYSYLNPQDGRPLFHPAVDRALKLCGS-GGPPHVKLIVEWEHRIKDCLFGNIQ 570

  Fly   696 QDTEEAVVEHESVARLSASKPSDTAALTLEQCLEHYTKAETLSAEDAWRCPHCQQYLPVVKTLGL 760
               ||.|.:.||| |..........:.||::|.|.|||.|.|:.:|||:||||:|.......:.|
Zfish   571 ---EEVVKDSESV-RAQQQHHVQQHSCTLDECFELYTKEEQLAPDDAWKCPHCKQLQQGTVQMSL 631

  Fly   761 WSLPDILVVHFKRFRQHQSKGPQAAKLTTMVKFPLTAFDMSPHLARGVHESASSSLGMGTGIGLG 825
            |:|||||::|.|||||   .|.:..||:|:|.||||..||..|:   |..::.:....|
Zfish   632 WTLPDILILHLKRFRQ---VGERRNKLSTLVHFPLTGLDMGRHM---VQRTSCARAPPG------ 684

  Fly   826 LGLGSNPWKK---ARSVDSRSSTLNSRCDAKDTRYDLYAVCYHQGDTLETGHYTAACKNPYDRQW 887
                   |.|   .|...||.:|        |..|||||||.|.|. :..|||||.|:|..|.||
Zfish   685 -------WNKQAHRRPEASRYAT--------DVLYDLYAVCNHHGG-MHGGHYTAYCRNSVDGQW 733

  Fly   888 YKFDDQRVSKVPEDDIEQDIINNEAYMLFYQRRSVDA-----GECS--GSSSNS-GDHWVSR--- 941
            |.:||..|..:.|.    ::....||:||||||  ||     ..||  ||||:| .|||:.|
Zfish   734 YTYDDSSVEPLQEG----EVCTRAAYILFYQRR--DAIPSWSASCSRQGSSSSSLSDHWLIRLNA 792

  Fly   942 ---IAPASSSSASSTSGKE----REPV----KLEENTESPAAVEVTEKAQSKPVDIVCQDKAKGT 995
               |:.::|..::|:|..|    ..||    ..|:|.:...|.......:.:.:.:..|.|:|
Zfish   793 DEGISNSTSKVSNSSSAPEPQTPHSPVIHKSANEDNRDVAEATPFVRSVRGQSMSMRYQSKSK-- 855

  Fly   996 ADGPDADQEQTTVPHDLQIEELAFADADVDTSLGETIKAEVNLAAKDEPKKVEVEEATPIFAMDE 1060
                                          |..|:.:....:.|:|:..|       .|......
Zfish   856 ------------------------------TGSGKVLPLRWSFASKERRK-------PPSITSQN 883

  Fly  1061 DGSE----ARQEKKEECVKKEDELSEAPDVSELTAESKTNGHVSSSSSSSS----------SESS 1111
            |..|    ....::..|.|:       |.||.:.:.|:..||:....|.||          ..||
Zfish   884 DNDELVEYLESGRRPRCTKE-------PIVSIVASPSQVKGHLREDDSLSSPSCCSSLNGVERSS 941

  Fly  1112 LSSRSSPR-----SLSTS-VTAASTLQSK----------------FNGHMSAAP-ALFNGNGNTS 1153
            .....||:     |..|| :.|.|::.|:                .:..:..:| ||..||..:.
Zfish   942 SQGPDSPKVPEGQSRPTSDLNAVSSVDSRAKKCSKTTRQEHERTQASKSLQGSPTALSTGNSTSH 1006

  Fly  1154 QLSSSLQLSRHV------LHNHQ---WHGSRSSVSAVENATQHQQQQAAASLSLRHSFSTSSNYT 1209
            ...|:|:..|:.      :|..|   ..|.......:...:...|.|...|..:.|..:.||...
Zfish  1007 SRDSTLKRLRNPAAATSRIHPSQILMATGESRGKDGIHPVSSTSQLQDGCSKEVGHGKTLSSKSL 1071

  Fly  1210 ETLS-----------------SLLRKSANTCSKDTLLF---IDQQSHHHTAGLIEDDDDSYMGRS 1254
            ..||                 ::.:.::.|..:||.:|   ||.:..|.::. |::..|..:.|:
Zfish  1072 TKLSLSNGTLNGKVVEVRKTGTVHKSTSKTNGRDTQVFSNTIDMKRAHSSSN-IQNRLDMTLKRT 1135

  Fly  1255 LWI---SPVTP 1262
            |.:   .|:.|
Zfish  1136 LSLQRNGPLVP 1146

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp15-31	NP_611959.2	UBP12	<255..921	CDD:227847	267/705 (38%)
usp43b	XP_001920291.2	UBP12	<101..762	CDD:227847	269/714 (38%)