DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SiaT and st6gal2a

DIOPT Version :9

Sequence 1:	NP_523853.1	Gene:	SiaT / 37950	FlyBaseID:	FBgn0035050	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001153386.1	Gene:	st6gal2a / 403116	ZFINID:	ZDB-GENE-060322-4	Length:	514	Species:	Danio rerio

Alignment Length:	445	Identity:	144/445 - (32%)
Similarity:	216/445 - (48%)	Gaps:	88/445 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 REPGEVNSRQPG----------NGAYENSTGTERRLRKVIWKCIPTGNGTTGHRVPR---SVFHV 94
            ||..|.|...|.          .|..|:..|.:.            |.|.|..||.|   |..|.
Zfish   135 RERQEYNQDSPQEDEDEEEEVIGGEEEDEEGGDE------------GRGRTTKRVARHGSSDPHE 187

  Fly    95 RWNPNEKFIVESRENPAINSSKLAPHPRLKVSKNTKLTLSPKLYLCHDKHSELC--HNKTQQFRQ 157
            .:.|..|.||......:::...|:|          :|..:.|.||.::||....  |.|.:|.||
Zfish   188 YYVPRYKSIVHGLWKGSLSMGMLSP----------RLQRAMKDYLNNNKHGVAYRGHRKAKQSRQ 242

  Fly   158 RIVRAFEKAMVESVNESQANHYNVDYKPVFGDSFEEQYYPSTCLVMEAGVRVLRRKDAPFNKLPF 222
            :::...:|                                      ...:|.|...:.||:||.:
Zfish   243 QVLCELKK--------------------------------------REKIRTLDGAEMPFSKLGW 269

  Fly   223 GRLFPRQKLFR-NVKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTI 286
            .::.|...|.: :...:||||:|:|||::..|.||:.||:||.|:|||.|||.|:|.|||:||||
Zfish   270 QKIVPALPLSQIHRPGLKTCAVVTSAGAMLHSGLGKEIDSHDAVLRFNTAPTVGYERDVGNKTTI 334

  Fly   287 RVVNSQVVTKPEFDFTRAPIFRNVTIAAWDPGKYNGTLEDWLTSADYDLFSNYELYRRRYPKSRA 351
            |::|||::..|...|.|:.:::|||:.||||..|...|..|.::.||:||:.|..||.|:|....
Zfish   335 RIINSQILANPMHRFNRSSLYKNVTLVAWDPAPYTLNLHKWYSNPDYNLFTPYMEYRMRFPSQPF 399

  Fly   352 FLIDPHSVWRLWQSLQMFAGN-RPISKNPPSSGFIGLALLLPHCPQVDFVEYVPSTRLNGRCHYY 415
            :::.|..:|:||..:|  |.| ..|..|||||||||:.|::..|.:|...||:||.|....|||:
Zfish   400 YILHPKYIWQLWDVIQ--ANNLENIQPNPPSSGFIGILLMMSLCEEVHVYEYIPSLRQTDLCHYH 462

  Fly   416 SKEMNSACTFGSWHPLAAEKLMALDMNMAEDDDMSVFQFGILRIRRPDKLLCGFN 470
            .:..::|||.|::|||..||::...||:..:|::.         |:....|.|||
Zfish   463 ERYYDAACTLGAYHPLLYEKMLIQRMNIGSEDELK---------RKGKVTLPGFN 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SiaT	NP_523853.1	Glyco_transf_29	224..437	CDD:279159	96/214 (45%)
st6gal2a	NP_001153386.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	70..183		14/59 (24%)
st6gal2a	NP_001153386.1	Glyco_transf_29	283..504	CDD:279159	98/231 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	208	1.000	Domainoid score	I2806
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3478
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D231534at33208
OrthoFinder	1	1.000	-	-		FOG0002913
OrthoInspector	1	1.000	-	-		otm24805
orthoMCL	1	0.900	-	-		OOG6_109878
Panther	1	1.100	-	-	O	PTHR46059
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5281
SonicParanoid	1	1.000	-	-		X1922
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.000