DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SiaT and St6gal2

DIOPT Version :9

Sequence 1:	NP_523853.1	Gene:	SiaT / 37950	FlyBaseID:	FBgn0035050	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001094358.1	Gene:	St6gal2 / 301155	RGDID:	1559663	Length:	525	Species:	Rattus norvegicus

Alignment Length:	447	Identity:	132/447 - (29%)
Similarity:	198/447 - (44%)	Gaps:	121/447 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 HIQGVKAQPGREPGEVNSRQPGNG------------------AYEN---STGTERRLRKVIWKCI 76
            |.||....|  .||| :|.|.|.|                  ||::   ||...|.....:||
  Rat   144 HRQGALGLP--SPGE-SSWQSGPGQPKQEKLRHPRRGSLPEEAYDSDMLSTSMSRAFLYRLWK-- 203

  Fly    77 PTGNGTTGHRVPRSVFHVRWNPNEKFIVESRENPAINSSKLAPHPRLKVSKNTKLTLSPKLYLCH 141
                ||.                              |||:.         |.:|..:.:.|:..
  Rat   204 ----GTV------------------------------SSKML---------NPRLQKAMRYYMSF 225

  Fly   142 DKHSELCHNKTQQFRQRIVRAFEKAMVESVNESQANHYNVDYKPVFGDSFEEQYYPSTCLVMEAG 206
            :||.       .:|.:|..|...:...|.:.|.:                           ....
  Rat   226 NKHG-------VRFSRRGRREARRTGPELLCEMR---------------------------KRVR 256

  Fly   207 VRVLRRKDAPFNKL---------PFGRLFPRQKLFRNVKDIKTCAIVSSAGSLAGSKLGRFIDTH 262
            ||.|..|:|||:.|         |..:|.||        .:::||:|.|||::..|.||..||:|
  Rat   257 VRTLDGKEAPFSGLGWRPLVPGVPLSQLHPR--------GLRSCAVVMSAGAILNSSLGEEIDSH 313

  Fly   263 DIVMRFNHAPTQGHEVDVGSKTTIRVVNSQVVTKPEFDFTRAPIFRNVTIAAWDPGKYNGTLEDW 327
            |.|:|||.|||:|:|.|||:|||:|::|||::..|...|..:.::::|.:.||||..|:..|..|
  Rat   314 DAVLRFNSAPTRGYEKDVGNKTTVRIINSQILANPSHHFIDSSLYKDVILVAWDPAPYSANLNLW 378

  Fly   328 LTSADYDLFSNYELYRRRYPKSRAFLIDPHSVWRLWQSLQMFAGNRPISKNPPSSGFIGLALLLP 392
            ....||:||:.|..:|.:||....:::.|..:|:||..:|.....: |..|||||||||:.:::.
  Rat   379 YKKPDYNLFTPYIQHRLKYPTQPFYILHPKFIWQLWDIIQENTREK-IQPNPPSSGFIGILVMMS 442

  Fly   393 HCPQVDFVEYVPSTRLNGRCHYYSKEMNSACTFGSWHPLAAEKLMALDMNMAEDDDM 449
            .|.:|...||:||.|....|||:....::|||.|::|||..|||:...:|.....|:
  Rat   443 MCQEVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHPLLYEKLLVQRLNTGTQADL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SiaT	NP_523853.1	Glyco_transf_29	224..437	CDD:279159	87/212 (41%)
St6gal2	NP_001094358.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..183		10/40 (25%)
		Glyco_transf_29	277..507	CDD:395627	91/232 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	198	1.000	Domainoid score	I2990
eggNOG	1	0.900	-	-		E1_KOG2692
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	202	1.000	Inparanoid score	I3684
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D231534at33208
OrthoFinder	1	1.000	-	-		FOG0002913
OrthoInspector	1	1.000	-	-		otm45008
orthoMCL	1	0.900	-	-		OOG6_109878
Panther	1	1.100	-	-	O	PTHR46059
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1922
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870