DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SiaT and St6gal2

DIOPT Version :9

Sequence 1:	NP_523853.1	Gene:	SiaT / 37950	FlyBaseID:	FBgn0035050	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001334332.1	Gene:	St6gal2 / 240119	MGIID:	2445190	Length:	524	Species:	Mus musculus

Alignment Length:	445	Identity:	129/445 - (28%)
Similarity:	196/445 - (44%)	Gaps:	118/445 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 HIQGVKAQPGREPGEVNSR-----------QPGNG-----AYEN---STGTERRLRKVIWKCIPT 78
            |.||....|  .|||.:.|           .|..|     ||::   |....|.....:||
Mouse   144 HRQGALELP--SPGETSWRSGPVQPKQKLLHPRRGSLPEEAYDSDMLSASMSRAFLYRLWK---- 202

  Fly    79 GNGTTGHRVPRSVFHVRWNPNEKFIVESRENPAINSSKLAPHPRLKVSKNTKLTLSPKLYLCHDK 143
                                           .|::|..|          |.:|..:.:.|:..:|
Mouse   203 -------------------------------GAVSSKML----------NPRLQKAMRYYMSFNK 226

  Fly   144 HSELCHNKTQQFRQRIVRAFEKAMVESVNESQANHYNVDYKPVFGDSFEEQYYPSTCLVMEAGVR 208
            |.       .:||:|..|...:...|.:.|.:                           ....||
Mouse   227 HG-------VRFRRRGRREATRTGPELLCEMR---------------------------RRVRVR 257

  Fly   209 VLRRKDAPFNKL---------PFGRLFPRQKLFRNVKDIKTCAIVSSAGSLAGSKLGRFIDTHDI 264
            .|..::|||:.|         |..:|.||        .:.:||:|.|||::..|.||..||:||.
Mouse   258 TLDGREAPFSGLGWRPLVPGVPLSQLHPR--------GLSSCAVVMSAGAILNSSLGEEIDSHDA 314

  Fly   265 VMRFNHAPTQGHEVDVGSKTTIRVVNSQVVTKPEFDFTRAPIFRNVTIAAWDPGKYNGTLEDWLT 329
            |:|||.|||:|:|.|||:|||:|::|||::..|...|..:.::::|.:.||||..|:..|..|..
Mouse   315 VLRFNSAPTRGYEKDVGNKTTVRIINSQILANPSHHFIDSALYKDVILVAWDPAPYSANLNLWYK 379

  Fly   330 SADYDLFSNYELYRRRYPKSRAFLIDPHSVWRLWQSLQMFAGNRPISKNPPSSGFIGLALLLPHC 394
            ..||:||:.|..:||:||....:::.|..:|:||..:|.....: |..|||||||||:.:::..|
Mouse   380 KPDYNLFTPYIQHRRKYPTQPFYILHPKFIWQLWDIIQENTREK-IQPNPPSSGFIGILIMMSMC 443

  Fly   395 PQVDFVEYVPSTRLNGRCHYYSKEMNSACTFGSWHPLAAEKLMALDMNMAEDDDM 449
            .:|...||:||.|....|||:....::|||.|::|||..|||:...:|.....|:
Mouse   444 KEVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHPLLYEKLLVQRLNTGTQADL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SiaT	NP_523853.1	Glyco_transf_29	224..437	CDD:279159	88/212 (42%)
St6gal2	NP_001334332.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..174		5/23 (22%)
St6gal2	NP_001334332.1	Glyco_transf_29	276..506	CDD:395627	92/232 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I3035
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3774
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D231534at33208
OrthoFinder	1	1.000	-	-		FOG0002913
OrthoInspector	1	1.000	-	-		otm42939
orthoMCL	1	0.900	-	-		OOG6_109878
Panther	1	1.100	-	-	O	PTHR46059
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5281
SonicParanoid	1	1.000	-	-		X1922
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.000