Protein Alignment Mmp1 and MMP20

DIOPT Version :9

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_004762.2
• Gene: MMP20 / 9313
• HGNCID: 7167
• Length: 483
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 185/521 - (35%)
• Similarity: 250/521 - (47%)
• Gaps: 81/521 - (15%)

  Fly     7 SVFIVVGTLFSIMAAAQSAPVSTTTQ-----AEIYLS---------QFGYLPASARNPASSGLHD 57
            :||:::...||..|.:..|....|.:     |:.||.         |.|.:.|...|
Human    10 AVFLIMALKFSTAAPSLVAASPRTWRNNYRLAQAYLDKYYTNKEGHQIGEMVARGSN-------- 66

  Fly    58 QRTWVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRD----RVGTGDSRSKRYALQGSRWRV 118
              :.:..|:|.|:|.||.:||:||..||.::..|||||.|    |:..|:          .:|:.
Human    67 --SMIRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANYRLFPGE----------PKWKK 119

  Fly   119 KNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDG 183
            ..|||:||||...:..|:||..:..|...||....|:|.|..||...|.|.|...:|||...|||
Human   120 NTLTYRISKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDSYPFDG 184

  Fly   184 QGGTLAHAFFP--VFGGDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFY 246
            ..|||||||.|  ..|||.|||:||.||:|: .|.|||.||||||||:|||:||...||||.|.|
Human   185 PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT-NGFNLFTVAAHEFGHALGLAHSTDPSALMYPTY 248

  Fly   247 RGFEPV-FKLDEDDKAAIQSLYGRKTNQLRPTNVY---PATTQRPYSPPKVPLDDSICKDSKVDT 307
            :...|. |.|.:||...||:|||       |..|:   |.....|:..|.:|   .:|..|....
Human   249 KYKNPYGFHLPKDDVKGIQALYG-------PRKVFLGKPTLPHAPHHKPSIP---DLCDSSSSFD 303

  Fly   308 LFNSAQGETYAFKGDKYYKLTTDSVEEGY-PQLISKGWPGLPGNIDAAF-TYKNGKTYFFKGTQY 370
            .......|...|| |:.:......:..|. |..|:..:|.|..|:|||: ..:.|..|||||..|
Human   304 AVTMLGKELLLFK-DRIFWRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPHY 367

  Fly   371 WRYQGRQMDGVYPKEISEGFTGIPDH---LDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASY 432
            |..:|.||.|. |:.|.:  .|.|.|   :|||:......|..||.|.:::.:|..|| .::..|
Human   368 WITRGFQMQGP-PRTIYD--FGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKR-KMEKDY 428

  Fly   433 PKPI-SNWEGVPNNLDAALKYTNGYTYFFKGDKYYRF----HDARFAVDSATPPFPRPTAHWWFG 492
            ||.. ..:.||...:|||:: .|||.|||.|.|.|::    .|....|.|::          |.|
Human   429 PKNTEEEFSGVNGQIDAAVE-LNGYIYFFSGPKTYKYDTEKEDVVSVVKSSS----------WIG 482

  Fly   493 C 493
            |
Human   483 C 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	19/69 (28%)
		Peptidase_M10	115..268	CDD:278824	78/155 (50%)
		ZnMc_MMP	115..268	CDD:239805	78/155 (50%)
		HX	298..493	CDD:238046	63/204 (31%)
MMP20	NP_004762.2	PG_binding_1	35..95	CDD:279773	19/69 (28%)
		Cysteine switch. /evidence=ECO:0000250	98..105		5/6 (83%)
		Peptidase_M10	116..271	CDD:278824	78/155 (50%)
		ZnMc_MMP	116..271	CDD:239805	78/155 (50%)
		HX	293..483	CDD:238046	64/208 (31%)
		Hemopexin 1	293..343		11/53 (21%)
		Hemopexin 2	344..389		19/47 (40%)
		Hemopexin 3	391..439		13/48 (27%)
		Hemopexin 4	440..483		16/53 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148245
Domainoid	1	1.000	150	1.000	Domainoid score	I4381
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000127
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850