DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and Mmp14

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_112318.1	Gene:	Mmp14 / 81707	RGDID:	620198	Length:	582	Species:	Rattus norvegicus

Alignment Length:	595	Identity:	220/595 - (36%)
Similarity:	313/595 - (52%)	Gaps:	84/595 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IVVGTLFSIMAAAQSAPVSTTTQAEIYLSQFGYLPASARNPASSGLHDQRTWVS---AIEEFQSF 71
            :.:||..:.:..|||:..|    .|.:|.|:||||     |.....|.||:..|   ||...|.|
  Rat    16 LTLGTTLASLGWAQSSNFS----PEAWLQQYGYLP-----PGDLRTHTQRSPQSLSAAIAAMQRF 71

  Fly    72 AGLNITGELDAETMKLMSLPRCGVRDRVGT---GDSRSKRYALQGSRWRVKNLTYKISKYPKRLK 133
            .||.:||:.|::|||.|..|||||.|:.||   .:.|.||||:||.:|:...:|:.|..|..::.
  Rat    72 YGLQVTGKADSDTMKAMRRPRCGVPDKFGTEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVG 136

  Fly   134 RVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVH--------IEIKFVESEHGDGDAFDGQGGTLAH 190
            .......|.:||.||...|.|.|.......:.        |.|.|.|..|||...|||:||.|||
  Rat   137 EYATFEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMILFAEGFHGDSTPFDGEGGFLAH 201

  Fly   191 AFF--PVFGGDAHFDDAELWTIGSP--RGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEP 251
            |:|  |..|||.|||.||.||:.:.  .|.::|.||.||.||:|||.||:..||:|||||:..:.
  Rat   202 AYFPGPNIGGDTHFDSAEPWTVQNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDT 266

  Fly   252 V-FKLDEDDKAAIQSLYGRKTNQLRPTNV--YPATTQRPYSP--PKVP-LDDSICKDSKVDTLFN 310
            . |.|.:||:..||.|||.|:..  ||.:  .|.||.||..|  |:.| ...:|| |...||: .
  Rat   267 ENFVLPDDDRRGIQQLYGSKSGS--PTKMPPQPRTTSRPSVPDKPRNPTYGPNIC-DGNFDTV-A 327

  Fly   311 SAQGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAFTYKNGKTYFFKGTQYWRYQG 375
            ..:||.:.||...::::..:.|.:|||..|.:.|.|||.:|:.|:..|:||..||||.::|.:..
  Rat   328 MLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDE 392

  Fly   376 RQMDGVYPKEISEGFTGIP-DHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPISNW 439
            ..::..|||.|.|...|:| |.:|||:.|..|||.|||:|:|::||:...| .|.:.|||.|..|
  Rat   393 ASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEEFR-AVDSEYPKNIKVW 456

  Fly   440 EGVPNNLDAALKYTNG-YTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHWWFGCKNTPSSTGNI 503
            ||:|.:...:...::. :|||:||:||::|::.:..|:   |.:|:.....|.||   ||. |..
  Rat   457 EGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVE---PGYPKSALRDWMGC---PSG-GRP 514

  Fly   504 VEGSDNEFEQHSMIPHADDGNGDDFDAAVGDHQSNDEPIVPEVAERTGNGAMSQSKLTSSSAVST 568
            .||::.|                            .|.|:.||.|. |:||:        ||.:.
  Rat   515 DEGTEEE----------------------------TEVIIIEVDEE-GSGAV--------SAAAV 542

  Fly   569 VITTILMCLV 578
            |:..:|:.||
  Rat   543 VLPVLLLLLV 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	24/58 (41%)
		Peptidase_M10	115..268	CDD:278824	67/165 (41%)
		ZnMc_MMP	115..268	CDD:239805	67/165 (41%)
		HX	298..493	CDD:238046	72/196 (37%)
Mmp14	NP_112318.1	PG_binding_1	36..88	CDD:396175	24/56 (43%)
		Cysteine switch. /evidence=ECO:0000250	91..98		5/6 (83%)
		Peptidase_M10	118..284	CDD:395334	67/165 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..317		15/38 (39%)
		HX	316..508	CDD:238046	72/197 (37%)
		Hemopexin 1	316..364		15/49 (31%)
		Hemopexin 2	365..410		16/44 (36%)
		Hemopexin 3	412..460		24/48 (50%)
		Hemopexin 4	461..508		12/49 (24%)
		DUF3377	<560..582	CDD:403153
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I12049
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H21040
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2310
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44496
orthoMCL	1	0.900	-	-		OOG6_101521
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.870