DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp1 and Mmp2

DIOPT Version :9

Sequence 1:NP_726473.2 Gene:Mmp1 / 37949 FlyBaseID:FBgn0035049 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_112316.2 Gene:Mmp2 / 81686 RGDID:621316 Length:662 Species:Rattus norvegicus


Alignment Length:684 Identity:177/684 - (25%)
Similarity:242/684 - (35%) Gaps:238/684 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 VVGTLFSIMAAAQSAP---------VSTTTQAEI---YLSQFGYLPASARNPASSGLHDQRTWV- 62
            |:..|..::..|.:||         ||..|..|:   ||:.|...|..:.|          .:| 
  Rat    16 VLCVLCCLLGHAIAAPSPIIKFPGDVSPKTDKELAVQYLNTFYGCPKESCN----------LFVL 70

  Fly    63 -SAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVGTGDSRSKRYALQGSRWRVKNLTYKIS 126
             ..:::.|.|.||..||:||..|::.|..|||      |..|..:..:..:..:|....:||:|.
  Rat    71 KDTLKKMQKFFGLPQTGDLDQNTIETMRKPRC------GNPDVANYNFFPRKPKWDKNQITYRII 129

  Fly   127 KYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHA 191
            .|...|....||....||..|||:.|.|.|:|...|...|.|.|...|||||..|||:.|.||||
  Rat   130 GYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHA 194

  Fly   192 FFP--VFGGDAHFDDAELWTIGS------------------------------------------ 212
            |.|  ..|||:||||.||||:|.                                          
  Rat   195 FAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGREYSSCTDTGRSDGFLWC 259

  Fly   213 ----------------------------------------------------------------- 212
                                                                             
  Rat   260 STTYNFEKDGKYGFCPHEALFTMGGNGDGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYD 324

  Fly   213 ----------------------------------------------------------------- 212
                                                                             
  Rat   325 RDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKVWCATTTNYDDDRKWGF 389

  Fly   213 --PRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPVFKLDEDDKAAIQSLYGRKTNQLR 275
              .:|.:||.||||||||::||.||....|||||.|. :...|:|..||...||.|||...:...
  Rat   390 CPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYT-YTKNFRLSNDDIKGIQELYGPSPDADT 453

  Fly   276 PTNVYPATTQRPYSPPKVPLDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQLI 340
            .|...|..|..|.:|       .|||...|.......:||.:.||....::..|...:...|.|:
  Rat   454 DTGTGPTPTLGPVTP-------EICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPTGPLLV 511

  Fly   341 SKGWPGLPGNIDAAF-TYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGIP---DHLDAAM 401
            :..||.||..|||.: ..:..|..||.|.:||.|....::..|||.::.  .|:|   ..:|||.
  Rat   512 ATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTS--LGLPPDVQQVDAAF 574

  Fly   402 VWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPIS-NWEGVPNNLDAALKYT-NGYTYFFKGDK 464
            .|..|.|.|.|.|.||||::..|: .:...:||.|: :|..:|:||||.:... .|::|||||..
  Rat   575 NWSKNKKTYIFSGDKFWRYNEVKK-KMDPGFPKLIADSWNAIPDNLDAVVDLQGGGHSYFFKGAY 638

  Fly   465 YYRFHD-----ARFAVDSATPPFPRPTAHWWFGC 493
            |.:..:     .:|....:.          |.||
  Rat   639 YLKLENQSLKSVKFGSIKSD----------WLGC 662

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp1NP_726473.2 PG_binding_1 32..88 CDD:279773 16/60 (27%)
Peptidase_M10 115..268 CDD:278824 76/328 (23%)
ZnMc_MMP 115..268 CDD:239805 76/328 (23%)
HX 298..493 CDD:238046 62/205 (30%)
Mmp2NP_112316.2 PG_binding_1 <70..97 CDD:396175 9/26 (35%)
Cysteine switch. /evidence=ECO:0000250 100..107 4/12 (33%)
Collagenase-like 1 110..221 48/110 (44%)
Peptidase_M10 118..446 CDD:395334 76/328 (23%)
Collagen-binding 222..396 1/173 (1%)
FN2 226..274 CDD:128373 0/47 (0%)
FN2 284..332 CDD:128373 0/47 (0%)
FN2 342..390 CDD:128373 0/47 (0%)
Collagenase-like 2 397..467 33/70 (47%)
Required for inhibitor TIMP2 binding. /evidence=ECO:0000250 414..662 83/268 (31%)
HX 468..662 CDD:238046 63/213 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 151 1.000 Domainoid score I4255
eggNOG 1 0.900 - - E1_KOG1565
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1075463at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10201
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X44
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.920

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