Protein Alignment Mmp1 and MMP28

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_077278.1
• Gene: MMP28 / 79148
• HGNCID: 14366
• Length: 520
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 170/517 - (32%)
• Similarity: 252/517 - (48%)
• Gaps: 82/517 - (15%)

  Fly    32 QAEIYLSQFGYLPASA-RNPASSGLHDQRTWVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGV 95
            :||.:|.::|||.... :.|.|:...|      ||..||..:.|.::|.||..|::.|:.|||||
Human    35 EAEAFLEKYGYLNEQVPKAPTSTRFSD------AIRAFQWVSQLPVSGVLDRATLRQMTRPRCGV 93

  Fly    96 RD----------------RVGTGDSRSKRYALQGSRWRVKNLTYKISKYPKRLKRVDVDAEIGRA 144
            .|                |..|...|.||:|.||::|..::|:|::..:|:.|....|...:..|
Human    94 TDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAA 158

  Fly   145 FAVWSEDTDLTF-TRKTSGPVHIEIKFVESEHGD--GDAFDGQGGTLAHAFFPVFGGDAHFDDAE 206
            |.:||..:.|.| ....:||..|.:.|.:.:|.|  |:||||.||.|||||.| ..|:||||..|
Human   159 FQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLP-RRGEAHFDQDE 222

  Fly   207 LWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPVFKLDEDDKAAIQSLYGRKT 271
            .|::...||.|||.|.|||.||:|||:||....|||||:|:.......|..||..|:|||||:..
Human   223 RWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPL 287

  Fly   272 N-----QLRPTNVYPATTQRPYSP---------PKVPLDDSICKDSKVDTLFNSAQGETYAFKGD 322
            .     ||.........|...|||         ||      .| .|..|.:....|.:.|.|||.
Human   288 GGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPK------YC-HSSFDAITVDRQQQLYIFKGS 345

  Fly   323 KYYKLTTD-SVEEGYPQLISKGWPGLPGNID-AAFTYKNGKTYFFKGTQYWRYQGRQMDGVYPKE 385
            .::::..| :|.|  |:.:.:.|.|||.||: ||.:..:|..|||||.:.||::|.:.....|:.
Human   346 HFWEVAADGNVSE--PRPLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQL 408

  Fly   386 ISEGFTGIPDHLDAAMVWGGNGKIYFFKGSKFW-------RFDPAKRPPVKASYPKPISNWEGVP 443
            ...|  |:|.|.|||:.:....::..|||::::       :.:|        .||:.:.:|.|:|
Human   409 CRAG--GLPRHPDAALFFPPLRRLILFKGARYYVLARGGLQVEP--------YYPRSLQDWGGIP 463

  Fly   444 NNLDAALKYTNGYTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHW-----WFGCKNTPSST 500
            ..:..||...:|...||:.|:|:|...|:....:        :..|     |.||.:..|.:
Human   464 EEVSGALPRPDGSIIFFRDDRYWRLDQAKLQATT--------SGRWATELPWMGCWHANSGS 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	18/56 (32%)
		Peptidase_M10	115..268	CDD:425668	67/155 (43%)
		HX	298..493	CDD:238046	57/208 (27%)
MMP28	NP_077278.1	PG_binding_1	31..86	CDD:460223	18/56 (32%)
		Cysteine switch. /evidence=ECO:0000250	89..96		5/6 (83%)
		ZnMc_MMP	129..284	CDD:239805	67/155 (43%)
		HX	321..510	CDD:238046	59/215 (27%)
		Hemopexin 1	325..369		12/45 (27%)
		Hemopexin 2	370..409		15/38 (39%)
		Hemopexin 3	415..463		13/55 (24%)
		Hemopexin 4	464..510		11/53 (21%)