DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and mmp30

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_001035381.1	Gene:	mmp30 / 678531	ZFINID:	ZDB-GENE-060421-5765	Length:	475	Species:	Danio rerio

Alignment Length:	497	Identity:	178/497 - (35%)
Similarity:	255/497 - (51%)	Gaps:	61/497 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTNCQSSVFIVVGTLFSIMAAAQSAPVSTTTQ-----AEIYLSQFGYLPASARNPASSGLHDQRT 60
            |.:..:::.:||.     :.....||.:|.:.     ||.||||| |..:.|.....      |.
Zfish     1 MAHWPAALILVVS-----LTLCNGAPTTTPSTEDREIAEAYLSQF-YRDSKAAKTLG------RM 53

  Fly    61 WVSAIEE----FQSFAGLNITGELDAETMKLMSLPRCGVRDRVGTGDSRSKRYALQGSRWRVKNL 121
            :||.:|.    .|||.||.:||:||:.|:|.|.||||||.|....|....|      .||:...:
Zfish    54 FVSNLENELKAMQSFFGLEVTGQLDSNTLKTMKLPRCGVTDVARFGHFEGK------PRWKQSVV 112

  Fly   122 TYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGG 186
            ||:|::|..:|.:.:||:.|.:||.::|:...:.|.:..||...|.|.|...:|||...|||..|
Zfish   113 TYRITEYTTQLSQREVDSTIAKAFQLYSDVIPVDFKQIFSGTADIMILFKGGDHGDFYPFDGPNG 177

  Fly   187 TLAHAFF--PVFGGDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGF 249
            .||||..  |..|||.||||.|.|::.| ...||..||||||||:|||.||..|||||.|.||..
Zfish   178 VLAHANSPGPEQGGDTHFDDDEKWSLSS-HNINLLLVAAHEFGHALGLDHSRDSSALMYPTYRYV 241

  Fly   250 EP-VFKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSPPKVPLDDSICKDSKVDTLFNSA- 312
            .. .:.|..||:..:|:|||.:.:..:|.   |....:| :|...|.....||.   |.:|::|
Zfish   242 STNAYTLPRDDRLGVQALYGVRASTNKPE---PKPEPKP-NPQPAPSPPEPCKR---DLIFDAAT 299

  Fly   313 --QGETYAFKGDKYYKLTTDSVEEGYPQ-----LISKGWPGLPGNIDAAFTYKN-GKTYFFKGTQ 369
              :||.|.|| |:||      .::||..     .|...||.: .::|||:.::: |..:.|||.|
Zfish   300 RIRGELYFFK-DRYY------WKKGYYSGLTLLEIKTTWPSI-DSVDAAYEFQDKGTNFLFKGQQ 356

  Fly   370 YWRYQGRQMDGVYPKEISE-GFTGIPDHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYP 433
            :|..:|..:...|||.||. ||....:.:|||:.....|:..||.|||:|.|:. :...:...:|
Zfish   357 FWAVKGNTILSGYPKPISTYGFPSSVNKIDAAVHVKSTGRTLFFVGSKYWSFND-RTSKMDRGFP 420

  Fly   434 KPIS-NWEGVPNNLDAALKYTNGYTYFFKGDKY--YRFHDAR 472
            |.|| ::.|:.:.:|||.: ..||.||..|.:.  |.|...|
Zfish   421 KSISADFPGIGSKVDAAFE-NYGYLYFSDGARQTEYIFASRR 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	24/64 (38%)
		Peptidase_M10	115..268	CDD:278824	69/155 (45%)
		ZnMc_MMP	115..268	CDD:239805	69/155 (45%)
		HX	298..493	CDD:238046	62/188 (33%)
mmp30	NP_001035381.1	PG_binding_1	26..85	CDD:279773	24/65 (37%)
		Peptidase_M10	106..261	CDD:278824	69/155 (45%)
		ZnMc_MMP	106..261	CDD:239805	69/155 (45%)
		HX	293..474	CDD:238046	59/179 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000127
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920