DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp1 and MMP27

DIOPT Version :9

Sequence 1:NP_726473.2 Gene:Mmp1 / 37949 FlyBaseID:FBgn0035049 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_071405.2 Gene:MMP27 / 64066 HGNCID:14250 Length:513 Species:Homo sapiens


Alignment Length:517 Identity:178/517 - (34%)
Similarity:242/517 - (46%) Gaps:53/517 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 FIVVGTLFSIMAAAQSAPVSTTTQAEIYLSQFGYLPASARNPASS---GLHDQRTWVSAIEEFQS 70
            ||...:.|.::...::.......||  ||:||..|.....:...|   .|.|.:     |.|.|:
Human    11 FITFSSAFPLVRMTENEENMQLAQA--YLNQFYSLEIEGNHLVQSKNRSLIDDK-----IREMQA 68

  Fly    71 FAGLNITGELDAETMKLMSLPRCGVRDRVGTGDSRSKRYALQGSRWRVKNLTYKISKYPKRLKRV 135
            |.||.:||:||:.|:::|..|||||.| ||     ...|.|.|  ||..||||:|..|...:.|.
Human    69 FFGLTVTGKLDSNTLEIMKTPRCGVPD-VG-----QYGYTLPG--WRKYNLTYRIINYTPDMARA 125

  Fly   136 DVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDA-FDGQGGTLAHAF--FPVFG 197
            .||..|.....|||:.|.|.||:.:.|...|.|.|....||.... |||..|.|.|||  .|..|
Human   126 AVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGLG 190

  Fly   198 GDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEP-VFKLDEDDKA 261
            ||.|||:.|.|| ....|.|||.||||||||:||||||:..:|||.|.|...:| .:.|.:||..
Human   191 GDTHFDEDENWT-KDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQDDIN 254

  Fly   262 AIQSLYGRKTNQLRPTNVYPATTQRPYSPPKVPLDDSICKDSKVDTLFNSAQGETYAFKGDKYYK 326
            .|||:||....:       ||       .||.|.....|..........:.:.|...|||...::
Human   255 GIQSIYGGLPKE-------PA-------KPKEPTIPHACDPDLTFDAITTFRREVMFFKGRHLWR 305

  Fly   327 LTTDSVEEGYPQLISKGWPGLPGNIDAAFTYKNGKTYFFKGTQYWRYQGRQMDGVYPKEI-SEGF 390
            :..|..:..: :||:..||.||.::.||:.....|...||...:|..:|..:...|||.| :.||
Human   306 IYYDITDVEF-ELIASFWPSLPADLQAAYENPRDKILVFKDENFWMIRGYAVLPDYPKSIHTLGF 369

  Fly   391 TGIPDHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPISNWEGVPNNLDAALKYTNG 455
            .|....:|||:......|.|||.|...||||...:...|....:.:.::.|:...:|||.:| .|
Human   370 PGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGISIRVDAAFQY-KG 433

  Fly   456 YTYFFKGDKYYRFHDARFAVDSATPPFPR-PTAHWWFGCKNTPSSTGNIVEGSD-NEFEQHS 515
            :.:|.:|.|       :|..|..|....| ...:.||.||...:|:    .|.| |:.:.||
Human   434 FFFFSRGSK-------QFEYDIKTKNITRIMRTNTWFQCKEPKNSS----FGFDINKEKAHS 484

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp1NP_726473.2 PG_binding_1 32..88 CDD:279773 21/58 (36%)
Peptidase_M10 115..268 CDD:278824 73/156 (47%)
ZnMc_MMP 115..268 CDD:239805 73/156 (47%)
HX 298..493 CDD:238046 54/196 (28%)
MMP27NP_071405.2 PG_binding_1 26..86 CDD:279773 21/66 (32%)
Cysteine switch. /evidence=ECO:0000250 89..96 6/7 (86%)
Peptidase_M10 106..261 CDD:278824 73/155 (47%)
ZnMc_MMP 106..261 CDD:239805 73/155 (47%)
HX 276..465 CDD:238046 54/197 (27%)
Hemopexin 1 276..325 10/49 (20%)
Hemopexin 2 326..371 14/44 (32%)
Hemopexin 3 373..421 13/47 (28%)
Hemopexin 4 422..465 14/50 (28%)
Required for retention in the endoplasmic reticulum. /evidence=ECO:0000269|PubMed:24548619 466..513 7/23 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148248
Domainoid 1 1.000 150 1.000 Domainoid score I4381
eggNOG 1 0.900 - - E1_KOG1565
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1075463at2759
OrthoFinder 1 1.000 - - FOG0000127
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10201
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X44
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.850

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